Summary: AKAP7 2'5' RNA ligase-like domain
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AKAP7 2'5' RNA ligase-like domain Provide feedback
AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes . AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein . Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains PF02834. Presumably this domain carried out some as yet unknown enzymatic function.
Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B, Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD, Rosenthal W, Klussmann E; , Biochem J. 2006;396:297-306.: High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. PUBMED:16483255 EPMC:16483255
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019510
This entry represents the nuclear localisation signal-containing domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [PUBMED:12804576]. This domain carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [PUBMED:16483255].
The domain is also found in a number of other proteins, such as activating signal cointegrator 1 complex subunit 1 and leukocyte receptor cluster member 9.
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This clan includes a number of phosphoesterases that contain an internal duplication.
The clan contains the following 9 members:2_5_RNA_ligase2 2H-phosphodiest AKAP7_NLS CNPase Corona_NS2A CPDase DUF1045 HVSL LigT_PEase
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||Buljan M, Coggill P|
|Number in seed:||50|
|Number in full:||426|
|Average length of the domain:||205.50 aa|
|Average identity of full alignment:||22 %|
|Average coverage of the sequence by the domain:||57.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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