Summary: SNARE-complex protein Syntaxin-18 N-terminus
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SNARE-complex protein Syntaxin-18 N-terminus Provide feedback
This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates . More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes .
Hatsuzawa K, Hirose H, Tani K, Yamamoto A, Scheller RH, Tagaya M; , J Biol Chem. 2000;275:13713-13720.: Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. PUBMED:10788491 EPMC:10788491
Hatsuzawa K, Tamura T, Hashimoto H, Hashimoto H, Yokoya S, Miura M, Nagaya H, Wada I; , Mol Biol Cell. 2006;17:3964-3977.: Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. PUBMED:16790498 EPMC:16790498
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019529
This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates [PUBMED:10788491]. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes [PUBMED:16790498].
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Curation and family details
|Author:||Buljan M, Coggill P|
|Number in seed:||33|
|Number in full:||245|
|Average length of the domain:||81.90 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||24.35 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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