Summary: Nuclear RNA-splicing-associated protein
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Nuclear RNA-splicing-associated protein Provide feedback
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing . SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway .
Sasahara K, Yamaoka T, Moritani M, Tanaka M, Iwahana H, Yoshimoto K, Miyagawa J, Kuroda Y, Itakura M; , Biochem Biophys Res Commun. 2000;269:444-450.: Molecular cloning and expression analysis of a putative nuclear protein, SR-25. PUBMED:10708573 EPMC:10708573
Lee SC, Sim N, Clement MV, Yadav SK, Pervaiz S; , Proteomics. 2007;7:4112-4122.: Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis. PUBMED:17952876 EPMC:17952876
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019532
SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissue types. At the N terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing [PUBMED:10708573]. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1; also see INTERPRO) signalling pathway [PUBMED:17952876].
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Curation and family details
|Author:||Buljan M, Coggill P|
|Number in seed:||6|
|Number in full:||90|
|Average length of the domain:||186.70 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||80.28 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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