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15  structures 1320  species 0  interactions 5534  sequences 84  architectures

Family: EPL1 (PF10513)

Summary: Enhancer of polycomb-like

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Enhancer of polycomb-like Provide feedback

This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes [3].

Literature references

  1. Zhang H, Richardson DO, Roberts DN, Utley R, Erdjument-Bromage H, Tempst P, Cote J, Cairns BR; , Mol Cell Biol. 2004;24:9424-9436.: The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres. PUBMED:15485911 EPMC:15485911

  2. Stankunas K, Berger J, Ruse C, Sinclair DA, Randazzo F, Brock HW; , Development 1998;125:4055-4066.: The enhancer of polycomb gene of Drosophila encodes a chromatin protein conserved in yeast and mammals. PUBMED:9735366 EPMC:9735366

  3. Selleck W, Fortin I, Sermwittayawong D, Cote J, Tan S; , Mol Cell Biol. 2005;25:5535-5542.: The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. PUBMED:15964809 EPMC:15964809


This tab holds annotation information from the InterPro database.

InterPro entry IPR019542

This domain is found at the N-terminal of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes [ PUBMED:15964809 ]. It is also present at the N terminus of Jade family proteins.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(111)
Full
(5534)
Representative proteomes UniProt
(9109)
RP15
(710)
RP35
(2164)
RP55
(4429)
RP75
(6203)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(111)
Full
(5534)
Representative proteomes UniProt
(9109)
RP15
(710)
RP35
(2164)
RP55
(4429)
RP75
(6203)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(111)
Full
(5534)
Representative proteomes UniProt
(9109)
RP15
(710)
RP35
(2164)
RP55
(4429)
RP75
(6203)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_3033 (release 22.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Mistry J , Wood V
Number in seed: 111
Number in full: 5534
Average length of the domain: 164.90 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 17.28 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.4 25.4
Trusted cut-off 25.4 25.4
Noise cut-off 25.3 25.3
Model length: 174
Family (HMM) version: 11
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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The tree shows the occurrence of this domain across different species. More...

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Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the EPL1 domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0XJK6 View 3D Structure Click here
A0A0R0EI44 View 3D Structure Click here
A0A0R0FFS8 View 3D Structure Click here
A0A0R4ICZ3 View 3D Structure Click here
A0A0R4IS80 View 3D Structure Click here
A0A1D6E2H8 View 3D Structure Click here
A0A1D6ENK7 View 3D Structure Click here
A0A1D6FFB2 View 3D Structure Click here
A0A1D6I1B3 View 3D Structure Click here
A0A1D6IXL7 View 3D Structure Click here
A0A1D6MJD8 View 3D Structure Click here
A3KNA6 View 3D Structure Click here
B2KF05 View 3D Structure Click here
B2RRD7 View 3D Structure Click here
D3ZM64 View 3D Structure Click here
D3ZMD3 View 3D Structure Click here
D3ZUW8 View 3D Structure Click here
D4A411 View 3D Structure Click here
D4ADG5 View 3D Structure Click here
E7F8E2 View 3D Structure Click here
F1M6J5 View 3D Structure Click here
F1QFR1 View 3D Structure Click here
F1R0J6 View 3D Structure Click here
F1RDZ9 View 3D Structure Click here
F4JV27 View 3D Structure Click here
F6P390 View 3D Structure Click here
G5E8P1 View 3D Structure Click here
H9GXF8 View 3D Structure Click here
I1JFM8 View 3D Structure Click here
I1M9N4 View 3D Structure Click here
I1MWL9 View 3D Structure Click here
K7LIE1 View 3D Structure Click here
K7LXT7 View 3D Structure Click here
K7M6G4 View 3D Structure Click here
K7TVJ2 View 3D Structure Click here
O74759 View 3D Structure Click here
O95696 View 3D Structure Click here
P43572 View 3D Structure Click here
P55201 View 3D Structure Click here
Q12311 View 3D Structure Click here
Q52LR7 View 3D Structure Click here
Q54JZ0 View 3D Structure Click here
Q54QM3 View 3D Structure Click here
Q5AAG1 View 3D Structure Click here
Q5ANJ1 View 3D Structure Click here
Q5VRT7 View 3D Structure Click here
Q6IE81 View 3D Structure Click here
Q6IE82 View 3D Structure Click here
Q6YUA2 View 3D Structure Click here
Q6Z0F1 View 3D Structure Click here
Q6ZPI0 View 3D Structure Click here
Q7JVP4 View 3D Structure Click here
Q7ZVP1 View 3D Structure Click here
Q803A0 View 3D Structure Click here
Q8C0I4 View 3D Structure Click here
Q8C9X6 View 3D Structure Click here
Q8GYQ9 View 3D Structure Click here
Q92613 View 3D Structure Click here
Q9FX82 View 3D Structure Click here
Q9H2F5 View 3D Structure Click here
Q9LZ30 View 3D Structure Click here
Q9NQC1 View 3D Structure Click here
Q9ULD4 View 3D Structure Click here
Q9UU94 View 3D Structure Click here