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0  structures 211  species 0  interactions 336  sequences 12  architectures

Family: Tom37 (PF10568)

Summary: Outer mitochondrial membrane transport complex protein

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Outer mitochondrial membrane transport complex protein Provide feedback

The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane [1]. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex [2].

Literature references

  1. Bowers M, Ardehali H; , J Mol Cell Cardiol. 2006;41:406-409.: TOM20 and the heartbreakers: evidence for the role of mitochondrial transport proteins in cardioprotection. PUBMED:16890951 EPMC:16890951

  2. Lister R, Carrie C, Duncan O, Ho LH, Howell KA, Murcha MW, Whelan J; , Plant Cell. 2007;19:3739-3759.: Functional definition of outer membrane proteins involved in preprotein import into mitochondria. PUBMED:17981999 EPMC:17981999


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR019564

Tom37 is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with Tom70, it guides peptides without an mitochondrial targeting sequence (MTS) into Tom40, the protein that forms the passage through the outer membrane [PUBMED:16890951]. It has homology with metaxin, also part of the outer mitochondrial membrane beta-barrel protein transport complex [PUBMED:17981999].

This entry represents outer mitochondrial membrane transport complex proteins Tom37 and metaxin.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

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Pfam Clan

This family is a member of clan Thioredoxin (CL0172), which has the following description:

This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.

The clan contains the following 45 members:

2Fe-2S_thioredx AhpC-TSA AhpC-TSA_2 ArsC ArsD Calsequestrin DIM1 DSBA DUF1525 DUF1687 DUF2703 DUF4174 DUF836 DUF899 DUF953 ERp29_N Glutaredoxin GSHPx GST_N GST_N_2 GST_N_3 HyaE KaiB MRP-S23 MRP-S25 OST3_OST6 Phosducin Redoxin SCO1-SenC SelP_N SH3BGR T4_deiodinase Thioredox_DsbH Thioredoxin Thioredoxin_2 Thioredoxin_3 Thioredoxin_4 Thioredoxin_5 Thioredoxin_6 Thioredoxin_7 Thioredoxin_8 Thioredoxin_9 Tom37 TraF YtfJ_HI0045

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the NCBI sequence database, and our metagenomics sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(17)
Full
(336)
Representative proteomes NCBI
(319)
Meta
(1)
RP15
(40)
RP35
(81)
RP55
(150)
RP75
(210)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(17)
Full
(336)
Representative proteomes NCBI
(319)
Meta
(1)
RP15
(40)
RP35
(81)
RP55
(150)
RP75
(210)
Alignment:
Format:
Order:
Sequence:
Gaps:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(17)
Full
(336)
Representative proteomes NCBI
(319)
Meta
(1)
RP15
(40)
RP35
(81)
RP55
(150)
RP75
(210)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_30563 (release 22.0)
Previous IDs: none
Type: Family
Author: Wood V, Coggill P
Number in seed: 17
Number in full: 336
Average length of the domain: 67.70 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 20.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.5 21.5
Trusted cut-off 21.5 21.6
Noise cut-off 21.3 21.3
Model length: 72
Family (HMM) version: 4
Download: download the raw HMM for this family

Species distribution

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