Summary: Outer mitochondrial membrane transport complex protein
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The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane . It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex .
Lister R, Carrie C, Duncan O, Ho LH, Howell KA, Murcha MW, Whelan J; , Plant Cell. 2007;19:3739-3759.: Functional definition of outer membrane proteins involved in preprotein import into mitochondria. PUBMED:17981999 EPMC:17981999
This tab holds annotation information from the InterPro database.
InterPro entry IPR019564This entry represents outer mitochondrial membrane transport complex proteins Sam37 and metaxin.
Sam37 is a component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex [PUBMED:12891361].
Metaxin is part of the outer mitochondrial membrane beta-barrel protein transport complex [PUBMED:17981999]. Metaxin is involved in transport of proteins into the mitochondrion and is eEssential for embryonic development [PUBMED:9045676].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||mitochondrial outer membrane (GO:0005741)|
|Biological process||protein targeting to mitochondrion (GO:0006626)|
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This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.
The clan contains the following 56 members:2Fe-2S_thioredx AhpC-TSA AhpC-TSA_2 Aminopep ArsC ArsD Calsequestrin DIM1 DSBA DUF1223 DUF1462 DUF1525 DUF1687 DUF2703 DUF2847 DUF4174 DUF836 DUF899 DUF953 ERp29_N Glutaredoxin GSHPx GST_N GST_N_2 GST_N_3 GST_N_4 HyaE KaiB L51_S25_CI-B8 Metallopep MRP-S23 MRP-S25 OST3_OST6 Peptidase_M76 Phosducin Rdx Redoxin SCO1-SenC SelP_N Sep15_SelM SH3BGR T4_deiodinase Thioredox_DsbH Thioredoxin Thioredoxin_2 Thioredoxin_3 Thioredoxin_4 Thioredoxin_5 Thioredoxin_6 Thioredoxin_7 Thioredoxin_8 Thioredoxin_9 Tom37 TraF YtfJ_HI0045 Zincin_1
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Curation and family details
|Seed source:||Pfam-B_30563 (release 22.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||161|
|Number in full:||514|
|Average length of the domain:||131.30 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||37.78 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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