Summary: Fanconi anemia group F protein (FANCF)
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Fanconi anemia group F protein (FANCF) Provide feedback
FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway .
Wang Z, Li M, Lu S, Zhang Y, Wang H; , Cancer Biol Ther. 2006;5:256-260.: Promoter hypermethylation of FANCF plays an important role in the occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA pathway. PUBMED:16418574 EPMC:16418574
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This tab holds annotation information from the InterPro database.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Author:||Pollington J, Finn RD|
|Number in seed:||7|
|Number in full:||69|
|Average length of the domain:||285.20 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||85.35 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FANCF domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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