Summary: Adenomatous polyposis coli tumour suppressor protein
Adenomatous polyposis coli tumour suppressor protein Provide feedback
The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils .
Tickenbrock L, Cramer J, Vetter IR, Muller O; , J Biol Chem. 2002;277:32332-32338.: The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1). PUBMED:12070164 EPMC:12070164
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This tab holds annotation information from the InterPro database.
InterPro entry IPR026831
The tumour suppressor protein adenomatous polyposis coli (APC) has a nuclear export activity as well as many different intracellular functions. The region close to the N terminus, termed APC-(129-250), consists of three alpha-helices forming two separate antiparallel coiled coils [PUBMED:12070164]. This entry represents a domain towards the N terminus that covers part of this region.
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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Curation and family details
|Author:||Pollington J, Finn RD|
|Number in seed:||32|
|Number in full:||313|
|Average length of the domain:||79.00 aa|
|Average identity of full alignment:||34 %|
|Average coverage of the sequence by the domain:||6.51 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Suppressor_APC domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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