Summary: B-cell lymphoma 9 protein
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B-cell lymphoma 9 protein Provide feedback
The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes .
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024670
The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. B-cell lymphoma 9 (BCL9) associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes [PUBMED:17052462].
This entry represents a beta-catenin binding domain found in BCL9 and BCL9 homologues.
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||12|
|Number in full:||182|
|Average length of the domain:||38.60 aa|
|Average identity of full alignment:||54 %|
|Average coverage of the sequence by the domain:||2.94 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the BCL9 domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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