# STOCKHOLM 1.0
#=GF ID Nab2
#=GF AC PF11517.10
#=GF DE Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)
#=GF AU Pollington J;0000-0002-8158-8998
#=GF GA 25.0 25.0
#=GF NC 24.8 24.3
#=GF TC 25.0 25.0
#=GF SE pdb_2jps
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 18190927
#=GF RT Structure of the N-terminal Mlp1-binding domain of the
#=GF RT Saccharomyces cerevisiae mRNA-binding protein, Nab2. 
#=GF RA Grant RP, Marshall NJ, Yang JC, Fasken MB, Kelly SM, Harreman
#=GF RA MT, Neuhaus D, Corbett AH, Stewart M; 
#=GF RL J Mol Biol. 2008;376:1048-1059.
#=GF DR INTERPRO; IPR021083;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Nab2 is a yeast heterogeneous nuclear ribonucleoprotein that
#=GF CC modulates poly(A) tail length and mRNA. This is the N terminal
#=GF CC domain of the protein which mediates interactions with the
#=GF CC C-terminal globular domain, Myosin-like protein 1 and the mRNA
#=GF CC export factor, Gfd1 [1].The N-terminal domain of Nab2 shows a
#=GF CC structure of a helical fold. The N terminal domain of Nab2 is
#=GF CC thought to mediate protein protein interactions that facilitate
#=GF CC the nuclear export of mRNA [1]. An essential hydrophobic Phe73
#=GF CC patch on the N terminal domain is thought to be a important
#=GF CC component of the interface between Nab2 and Mlp1 [1].
#=GF SQ 35
I2H5Z6.1/1-100       MS..QEQYAENLKVIVSEKLQTLPNFTEDVAYVAEYIVLLIVNGGSIESVVQELSTLF.DT.VSKD.NL.TDVVQTTFFAL..EALQQ..GETVDSI.VSKIRGLSAQQQA-
G8BPK2.1/1-99        MS..DDKIIENMKVIVAEKLNTLQNFNEDINYVAEYIVLLMSNGGSVESIVQELTTLF.DS.VSTE.VL.TDVVQTAFFAL..EAIQQ..GEPVANI.VEKIRGVAQATQ--
G8ZXT9.1/1-97        MS..QEQFTENLKVIVAEKLGTLPNFHEDIKYVAEYIVLLMVNGGTVETVVQELSTLF.DS.VSPD.SL.TDVVQTAFFAL..EALQQ..GETVDSI.VSKIRGSGSA----
Q6FU17.1/1-99        MS..QEQYTENLKVIVAERLKGVPNFNEDITYVAEYIVLLIVNGGTVESVVQELSSLF.DS.VSPE.AL.QDVVQTTFFAL..EALQQ..GESLENI.VDKIRMMNAQSA--
A7TJL5.1/1-99        MS..DNQIIEDMKVIVAEKLSTLQNFSEDVKYVAEYIVLLMSNGGSIESIVQELTTLF.DT.VSSE.AL.TDVVQTSFFAL..EALQQ..GETVTNI.VSKIRSVAGASA--
H2ANE5.1/1-100       MS..EQQYTESLKVIVAEKLKGVENFTEDVNYVAEYIVLLIVNGGTLESIVQELSTLF.DA.ISTD.AL.TNVVQTAFFAL..EALQQ..GETTESI.VSKIQAMNVQQTQ-
G0VEB8.1/1-99        MS..QEQYNESLKTIVAEKLNGIPNFNEDIKYVAEYIVLLISNGGTVEGVVTELSTLF.DT.LSTE.TL.MDVVQTTFFAL..EALQQ..GEPTEVI.VAKIREMNAAAA--
C5E402.1/1-100       MS..SEQYTENLKIIVAEKLGTLENFNEDIKYVAEYIVLLMVNGGTLENVVHELSTLF.DS.VSTE.AL.TDVVQTAFFAL..EALQQ..GETVDSI.VGKIRGVLQQPVQ-
A0A1X7R7M3.1/1-101   MS..QDQFSENLKVIVAEKLNGLPNFNEDVKYVAEYIVLLIVNGGTLESIVTELRSLF.DT.IPVE.AL.SDVIQTAFFAL..EALQQ..GESAENI.VSKIREMNAAEQQQ
J7S062.1/1-100       MS..QEQYTENLKVIVAEQLRGVHNFTEDVNYVAEYIVLLIVNGGDVESIVKELSTLF.DA.IPVD.VL.KDIVQTDFFAL..EALQQ..GETVDSI.VSKIRELNGNNQQ-
P32505.1/1-98        MS..QEQYTENLKVIVAEKLAGIPNFNEDIKYVAEYIVLLIVNGGTVESVVDELASLF.DS.VSRD.TL.ANVVQTAFFAL..EALQQ..GESAENI.VSKIRMMNAQS---
Q75E99.1/1-95        MSaiQDDISGSLKTVVAEKLKTLQNFSEDVNYVAEYIVLLLSNGGTHDSVLQELVGLF.DS.VPQQ.AL.ADVVQTSFQAL..QLLRS..GDNIETV.YQKLTN--------
A0A0C7N4X6.1/1-101   MSavQEEVVNNLKTIIAENLKTLPNFNEDVNYVAEYIVLLMSNGGNVDSVVQELTSLF.DT.VSAQ.AF.QSVAQNAYKAM..EYLQN..GDTLETT.MAKLTGQHATQT--
A0A1G4K0L0.1/1-99    MSgiQDEISKNLKLVVAESLKTLQNFNEDANYVAEYVVLLMSNGGTIESVVQELTSLF.DS.VPSE.AF.QNVVQQAFQAL..SYLQN..GDSLEIA.VSKLNGGNRV----
Q6CKL1.1/1-102       MStvPEYIASNLKTVISERLKVVPNFNEDVNQVAEYITLLMSNGSSGPDIVQELTSLF.DG.ISTQ.EF.QSVVSIAFTSA..DLLKA..GDDLNTV.YAKLSGNSSQPSS-
A0A1E5RFP0.1/6-100   --..AEEYSQCLNQFVSQYLSLIPNFNEDVNYVAEYIVLLMSNGGTVESVTTELQSLF.ES.TKPE.DI.QHIVTKAFEAV..QQLNN..GATPEQV.LDTVPKPGQQ----
A0A376BBE6.1/1-88    MSaiNESISEQLKHFVAECLTGLKNFSEDRTYVAEYIILLMSNGGSLEDVVKELHSLF.DT.VDVA.DL.QVVIEGAFVAA..STLNSntGNSS---.--------------
K0L048.1/1-81        MSglDQVVQEELKSFVAKQLTEAQDFTDDVKEVSEYITILISNNKSLEETTSELTTLF.DA.PSVP.V-.--IIGNAYKAL..SDFQN..GG-----.--------------
A0A1E3QNL0.1/7-98    --..-SQLAQELKVALTNRLQAL-NISDDADYVAEFIVVLISNDKTAQEITQELGSLF.DN.VIPE.SL.---IQDVFTEL..ENMQN..PQFQQQA.YQAQQAQQQAQA--
A0A1V2L412.1/6-83    --..TQEVQKELESFVAKQVQQIPELAEDANDVAEYLVLLVNYGRTPEQAYTELHSIF.--.-SSE.AL.TGVVQSAYKAL..EDYQN..TQQ----.--------------
W6MLI6.1/11-73       --..--EVGQRVKASISDMLKAI-NFSDDIEYVAEFIVVLISNGRTPEEITQELSALFgDA.ITLG.FV.NDV--------..-----..-------.--------------
A0A1E5RR26.1/23-100  --..--------------LLNLLPK-MDDVNSIAEYIVLLITNGSSKENIISEIAAV-.-G.INDSnIA.SDLIDRAFHAV..EQLKN..GATPDSI.FATIPSPQN-----
C4QYX4.1/9-75        --..ENELGQQLKSLVLKKLQSI-NFTDDPEYVSEFIVILISNNRSPDEITNELSSLFgDA.INQQ.FV.LSIFQ------..-----..-------.--------------
A0A1E4S9B0.1/5-81    --..-----EDFQRYIAEQLSLVPGFDEDIKEIAEYIALLVNNGRPLEETLSQLNDLF.G-.--NH.DL.RQTLENVYKAL..ETFNQ..QKLAAST.--------------
A0A1E4SX52.1/470-536 --..--EFGQQLKQTISDKLKQL-NLDEDPDYVSEFIVVLISNNRPPEVIVEELTTLFgDT.ITID.FI.QEQQQQQ----..-----..-------.--------------
A0A1E4TRL6.1/8-99    --..-SELGQQLKQIICEKLSQI-NLADDASDVADFVLVLISNNRTPSEIVQELSNLF.GD.IINE.EF.---VQSIFNDI..IKLKN..GAQQQQQ.LQQQQQEQQQNQ--
A0A448YM21.1/12-82   --..---YGQQLKTQIASKLEGL-NLSEDPEYVAEFLLVLISNNRTPDEILHEFNALFgDA.VDGN.FI.NEVVNEVRNPQ..Q----..-------.--------------
W1QK89.1/11-84       --..-EETFQQLKQQLSAKLAEM-NVTEDSEYVAEFILVLISNDKSPMSIMEELSALF.GD.IITL.EF.---IQSVFGEI..QRLRN..G------.--------------
A0A1E3PKK2.1/23-70   --..--------------QVSQL-NIGEDADYVAEFIVLMICNGKTSNEITKELVDLF.GD.NFTE.DF.S----------..-----..-------.--------------
A0A2U9QZB4.1/12-106  --..---LGQRLKQQIAAKLASLN--TEDPAYVAEFLLVLISNNRTRVEIVEEFTSLF.GN.IIDE.RFvQDVMDEINNNLngNQMQQ..SQQLQHSeQQQLQQQQQEQ---
A0A1Q2YAU8.1/14-83   --..-----VQLKQQISNRLASLN--TEDPSYVAEFLLVLISNNRTPAEIVEEFTGLF.GA.IIDQ.KFvVDVINEILIHQ..GKL--..-------.--------------
A0A1E3NIT1.1/14-76   --..-----VQLKQQISNRLASLN--TEDPSYVAEFLLVLISNNRTPAEIVEEFTGLF.GA.IIDQ.KFvVDVINEI----..-----..-------.--------------
A0A1E3NUA4.1/1-76    MSalDKNFKEELKNYLVAQISQIEGLADQATELSEYTVLLISNGRPFSETIEELQLIV.DS.---D.AV.PQIVRTAYEAL..EK---..-------.--------------
A0A4T0X765.1/21-69   --..-----------------SLANV-DDPEYVAEFLLVLISNNRSPAEIVNEFTGLF.GS.VIDE.AF.VQNVI------..-----..-------.--------------
A0A3F2XYK6.1/487-541 --..-----------VGKKLRSM-NLTDDPSYVAEFLLVLISNNRTAEEIMTEFNSLF.GNaININ.FV.NEVL-------..-----..-------.--------------
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