Summary: Heterogeneous nuclear ribonucleoprotein M
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Heterogeneous nuclear ribonucleoprotein M Provide feedback
HnRNP M is a splicing regulatory factor that binds to the auxiliary RNA cis-element ISE/ISS-2 which promotes splicing of exon IIIb and silencing of exon IIIC in the fibroblast growth factor receptor 2 (FGFR2) . By binding to ISE/ISS-3, HnRNP M plays a role in the regulation of alternative splicing in FGFR2 as it induces exon skipping and promotes exon inclusion .
Hovhannisyan RH, Carstens RP; , J Biol Chem. 2007;282:36265-36274.: Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons. PUBMED:17959601 EPMC:17959601
This tab holds annotation information from the InterPro database.
InterPro entry IPR024666
Heterogeneous nuclear ribonucleoproteins (hnRNPs) bind directly to nascent RNA polymerase II transcripts and play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs [PUBMED:8441656]. hnRNP M proteins are an abundant group of hnRNPs that have been shown to bind avidly to poly(G) and poly(U) RNA homopolymers [PUBMED:8441656]. hnRNP M family members are able to induce exon skipping and promote exon inclusion, suggesting that the proteins may broadly contribute to the fidelity of splice site recognition and alternative splicing regulation [PUBMED:17959601].
This entry represents the N-terminal PY nuclear localisation signal of heterogeneous nuclear ribonucleoprotein M [PUBMED:17435768].
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Curation and family details
|Number in seed:||4|
|Number in full:||92|
|Average length of the domain:||29.60 aa|
|Average identity of full alignment:||87 %|
|Average coverage of the sequence by the domain:||4.71 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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