Summary: Chromatin assembly factor 1 complex p150 subunit, N-terminal
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Chromatin assembly factor 1 complex p150 subunit, N-terminal Provide feedback
CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair . CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesised and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis .
Thiru A, Nietlispach D, Mott HR, Okuwaki M, Lyon D, Nielsen PR, Hirshberg M, Verreault A, Murzina NV, Laue ED; , EMBO J. 2004;23:489-499.: Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin. PUBMED:14765118 EPMC:14765118
Reese BE, Bachman KE, Baylin SB, Rountree MR;, Mol Cell Biol. 2003;23:3226-3236.: The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1. PUBMED:12697822 EPMC:12697822
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This tab holds annotation information from the InterPro database.
InterPro entry IPR021644
P150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair [PUBMED:14765118].P150 is the HP1 interaction site of CAF-1 and lies within the N-terminal region of the protein [PUBMED:14765118].
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Curation and family details
|Number in seed:||13|
|Number in full:||305|
|Average length of the domain:||187.60 aa|
|Average identity of full alignment:||19 %|
|Average coverage of the sequence by the domain:||26.44 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...