Summary: C3 binding domain 4 of IgG-bind protein SBI
C3 binding domain 4 of IgG-bind protein SBI Provide feedback
This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation . When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold .
Upadhyay A, Burman JD, Clark EA, Leung E, Isenman DE, van den Elsen JM, Bagby S; , J Biol Chem. 2008;283:22113-22120.: Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi. PUBMED:18550524 EPMC:18550524
This tab holds annotation information from the InterPro database.
InterPro entry IPR021657
This entry represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation [PUBMED:18550524]. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold [PUBMED:18550524].
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||1|
|Number in full:||5|
|Average length of the domain:||70.80 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||14.90 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Sbi-IV domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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