Summary: ATP-dependant DNA helicase UvsW
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This family of proteins represents the DNA helicase UvsW from bacteriophage T4. The protein is a member of the monomeric SF2 helicase superfamily and shows structural homology to the eukaryotic SF2 helicase Rad54. UvsW is thought to have a role in recombination and the rescue of stalled replication forks .
Carpene G, Vettoretti A, Pedini F, Rocco S, Mantero F, Opocher G; , J Chromatogr. 1991;553:201-204.: Hypertensive congenital adrenal enzymatic defects detected by high-performance liquid chromatography of corticosteroids. PUBMED:1787153 EPMC:1787153
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR020975
This entry represents the DNA helicase UvsW from Enterobacteria phage T4. The protein is a member of the monomeric SF2 helicase superfamily and shows structural homology to the eukaryotic SF2 helicase Rad54. UvsW is thought to have a role in recombination and the rescue of stalled replication forks [PUBMED:1787153].
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Curation and family details
|Number in seed:||2|
|Number in full:||51|
|Average length of the domain:||54.50 aa|
|Average identity of full alignment:||60 %|
|Average coverage of the sequence by the domain:||55.11 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||4|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UvsW domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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