Summary: Mite allergen Blo t 5
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This family of proteins is Blo t 5, an allergen protein from Blomia tropicalis mites. This protein shoes strong reactivity with IgE in asthmatic and rhinitis patients. The structure of the protein contains three alpha helices which form a coiled-coil .
Naik MT, Chang CF, Kuo IC, Kung CC, Yi FC, Chua KY, Huang TH; , Structure. 2008;16:125-136.: Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen. PUBMED:18184590 EPMC:18184590
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR020306
This entry contains mite allergens Der p 5 [PUBMED:18520154] and Blo t 5 [PUBMED:18684949], belonging to the mite group 5 allergen family, as well Blo t 21 [PUBMED:17445876] belonging to group 21. Mite allergens causes an allergic reaction in humans [PUBMED:17504089]. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Der p 5 binds to IgE.
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Curation and family details
|Number in seed:||7|
|Number in full:||41|
|Average length of the domain:||113.40 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||85.15 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Blo-t-5 domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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