Summary: Histone lysine methyltransferase SET associated
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Histone lysine methyltransferase SET associated Provide feedback
SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. A subset of SET domains have been called PR domains. The SET domain consists of two regions known as N-SET and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure . This domain is found in fungi associated with SET and N-SET domains.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024636
The SET domain is a protein-protein interaction domain found in protein lysine methyltransferase enzymes. This entry represents a domain of unknown function which is associated with the SET domain and found in histone lysine methyltransferases [PUBMED:12389037].
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Curation and family details
|Seed source:||Pfam-B_8752 (release 23.0)|
|Number in seed:||20|
|Number in full:||114|
|Average length of the domain:||69.40 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||5.99 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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