Summary: Tom37 C-terminal domain
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Tom37 C-terminal domain Provide feedback
The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane . It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex .
Lister R, Carrie C, Duncan O, Ho LH, Howell KA, Murcha MW, Whelan J; , Plant Cell. 2007;19:3739-3759.: Functional definition of outer membrane proteins involved in preprotein import into mitochondria. PUBMED:17981999 EPMC:17981999
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR019564
Tom37 is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with Tom70, it guides peptides without an mitochondrial targeting sequence (MTS) into Tom40, the protein that forms the passage through the outer membrane [PUBMED:16890951]. It has homology with metaxin, also part of the outer mitochondrial membrane beta-barrel protein transport complex [PUBMED:17981999].This entry represents outer mitochondrial membrane transport complex proteins Tom37 and metaxin.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||mitochondrial outer membrane (GO:0005741)|
|Biological process||protein targeting to mitochondrion (GO:0006626)|
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Curation and family details
|Seed source:||Pfam-B_30563 (release 22.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||17|
|Number in full:||336|
|Average length of the domain:||110.30 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||36.99 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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