# STOCKHOLM 1.0
#=GF ID   DUF3456
#=GF AC   PF11938.9
#=GF DE   TLR4 regulator and MIR-interacting MSAP
#=GF AU   Assefa S;0000-0003-2178-533X
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   PFAM-B_1799 (release 23.0)
#=GF GA   21.10 21.10;
#=GF TC   21.10 21.10;
#=GF NC   21.00 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16338228
#=GF RT   A molecule that is associated with Toll-like receptor 4 and
#=GF RT   regulates its cell surface expression.
#=GF RA   Konno K, Wakabayashi Y, Akashi-Takamura S, Ishii T, Kobayashi M,
#=GF RA   Takahashi K, Kusumoto Y, Saitoh S, Yoshizawa Y, Miyake K;
#=GF RL   Biochem Biophys Res Commun. 2006;339:1076-1082.
#=GF RN   [2]
#=GF RM   17998391
#=GF RT   A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is
#=GF RT   required for TLR-dependent immune responses.
#=GF RA   Takahashi K, Shibata T, Akashi-Takamura S, Kiyokawa T,
#=GF RA   Wakabayashi Y, Tanimura N, Kobayashi T, Matsumoto F, Fukui R,
#=GF RA   Kouro T, Nagai Y, Takatsu K, Saitoh S, Miyake K;
#=GF RL   J Exp Med. 2007;204:2963-2976.
#=GF RN   [3]
#=GF RM   18780723
#=GF RT   A single base mutation in the PRAT4A gene reveals differential
#=GF RT   interaction of PRAT4A with Toll-like receptors.
#=GF RA   Kiyokawa T, Akashi-Takamura S, Shibata T, Matsumoto F, Nishitani
#=GF RA   C, Kuroki Y, Seto Y, Miyake K;
#=GF RL   Int Immunol. 2008;20:1407-1415.
#=GF DR   INTERPRO; IPR021852;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins, found from plants to humans, is PRAT4
#=GF CC   (A and B), a Protein Associated with Toll-like receptor 4. The
#=GF CC   Toll family of receptors - TLRs - plays an essential role in
#=GF CC   innate recognition of microbial products, the first line of
#=GF CC   defence against bacterial infection [1]. PRAT4A influences the
#=GF CC   subcellular distribution and the strength of TLR responses and
#=GF CC   alters the relative activity of each TLR. PRAT4B regulates TLR4
#=GF CC   trafficking to the cell surface and the extent of its expression
#=GF CC   there [2][3]. TLR4 recognizes lipopolysaccharide (LPS), one of
#=GF CC   the most immuno-stimulatory glycolipids constituting the outer
#=GF CC   membrane of the Gram-negative bacteria.           This family
#=GF CC   has also been described as a SAP-like MIR-interacting protein
#=GF CC   family.
#=GF SQ   73
#=GS K1QUP8_CRAGI/33-191      AC K1QUP8.1
#=GS T1G0W0_HELRO/1-154       AC T1G0W0.1
#=GS H2XSM5_CIOIN/32-191      AC H2XSM5.1
#=GS A7SG92_NEMVE/48-204      AC A7SG92.1
#=GS A0A068Y828_ECHMU/27-174  AC A0A068Y828.1
#=GS W5N9H4_LEPOC/26-180      AC W5N9H4.1
#=GS I3KRZ0_ORENI/26-185      AC I3KRZ0.1
#=GS CNPY4_DANRE/26-185       AC Q2L6K8.1
#=GS F6SV63_ORNAN/131-288     AC F6SV63.2
#=GS G3WD91_SARHA/42-203      AC G3WD91.1
#=GS G5AN18_HETGA/36-195      AC G5AN18.1
#=GS H3A4A3_LATCH/27-186      AC H3A4A3.1
#=GS C3Y9Y9_BRAFL/43-203      AC C3Y9Y9.1
#=GS CNPY3_XENTR/27-187       AC Q5HZV5.2
#=GS M4A994_XIPMA/33-192      AC M4A994.2
#=GS CNPY3_DANRE/31-187       AC A3KNS2.1
#=GS G1QXD3_NOMLE/47-164      AC G1QXD3.2
#=GS CNPY3_MOUSE/48-206       AC Q9DAU1.1
#=GS E0VTA5_PEDHC/31-188      AC E0VTA5.1
#=GS H9J1K3_BOMMO/176-336     AC H9J1K3.1
#=GS T1KFJ8_TETUR/41-190      AC T1KFJ8.1
#=GS B7Q9D0_IXOSC/47-195      AC B7Q9D0.1
#=GS D6WZ22_TRICA/30-190      AC D6WZ22.1
#=GS C4WUW6_ACYPI/31-188      AC C4WUW6.1
#=GS A0A158NLW0_ATTCE/33-190  AC A0A158NLW0.1
#=GS B4QQC7_DROSI/35-196      AC B4QQC7.1
#=GS Q17CU1_AEDAE/31-191      AC Q17CU1.1
#=GS W4YKH6_STRPU/38-196      AC W4YKH6.1
#=GS F6PQZ3_CIOIN/58-219      AC F6PQZ3.1
#=GS A7RSQ2_NEMVE/45-188      AC A7RSQ2.1
#=GS Q381R4_TRYB2/53-198      AC Q381R4.1
#=GS Q4Q576_LEIMA/60-236      AC Q4Q576.1
#=GS E9H737_DAPPU/39-185      AC E9H737.1
#=GS B4MQX2_DROWI/26-172      AC B4MQX2.1
#=GS Q16KG3_AEDAE/37-184      AC Q16KG3.1
#=GS Q7PPM0_ANOGA/42-188      AC Q7PPM0.4
#=GS D6WRV5_TRICA/29-171      AC D6WRV5.2
#=GS E0VAC6_PEDHC/25-170      AC E0VAC6.1
#=GS K7IYX5_NASVI/27-171      AC K7IYX5.1
#=GS C4WRR6_ACYPI/26-171      AC C4WRR6.1
#=GS A0A088AH64_APIME/33-178  AC A0A088AH64.1
#=GS E2BUS3_HARSA/37-179      AC E2BUS3.1
#=GS A0A158NR17_ATTCE/30-175  AC A0A158NR17.1
#=GS C3YL01_BRAFL/28-173      AC C3YL01.1
#=GS W4XG20_STRPU/34-176      AC W4XG20.1
#=GS W5KLX1_ASTMX/28-174      AC W5KLX1.2
#=GS CNPY1_DANRE/31-177       AC Q2L6L1.1
#=GS H2LVG0_ORYLA/29-171      AC H2LVG0.2
#=GS G3PN37_GASAC/29-176      AC G3PN37.1
#=GS I3JTJ6_ORENI/29-177      AC I3JTJ6.1
#=GS F6WI24_XENTR/1-143       AC F6WI24.1
#=GS G1KKQ7_ANOCA/36-180      AC G1KKQ7.2
#=GS G1SHL3_RABIT/35-178      AC G1SHL3.2
#=GS F6S160_ORNAN/20-164      AC F6S160.1
#=GS G3WN37_SARHA/9-150       AC G3WN37.1
#=GS L8YCG7_TUPCH/27-171      AC L8YCG7.1
#=GS G1LSX8_AILME/28-167      AC G1LSX8.1
#=GS Q28FU2_XENTR/31-173      AC Q28FU2.1
#=GS A0A2H2HY78_CAEJA/28-166  AC A0A2H2HY78.1
#=GS Q95QN1_CAEEL/25-162      AC Q95QN1.1
#=GS U3JCI6_FICAL/44-186      AC U3JCI6.1
#=GS H3CNP8_TETNG/31-173      AC H3CNP8.1
#=GS H2Y6U3_CIOSA/25-179      AC H2Y6U3.1
#=GS K1RA73_CRAGI/25-167      AC K1RA73.1
#=GS D7UDC4_VITVI/24-164      AC D7UDC4.1
#=GS M1ALU1_SOLTU/63-203      AC M1ALU1.1
#=GS D7KMU1_ARALL/24-163      AC D7KMU1.1
#=GS I1NWL1_ORYGL/32-173      AC I1NWL1.1
#=GS M0S0V4_MUSAM/34-174      AC M0S0V4.1
#=GS A4RYT4_OSTLU/22-165      AC A4RYT4.1
#=GS Q017C7_OSTTA/27-169      AC Q017C7.1
#=GS C1FFA2_MICCC/31-175      AC C1FFA2.1
#=GS C1N2B6_MICPC/22-161      AC C1N2B6.1
K1QUP8_CRAGI/33-191                 MCE..VCKFF....VTELQSRLDETGKTKE...TLQVGHGLD......KKKKIVYHKSE........LRLTEALTDPHVC.DKILE.YNVHKERSGSN........RFAKGRSE.....................TME.TLHGLVNKG.VKVELGIPHELWDA......PSAEVTDMQRKCFKMAEEY.EDEIEDWYFN..HQ.EKDLMTYLCANRAL.RKDDKKC.
T1G0W0_HELRO/1-154                  ......CKFF....ATELKSRLDESARSKE...IIETGHGLD......RKKKFKYLTSE........LRLTEALHEPHIC.EKILE.YNVHAEREGSL........RYAKGMSE.....................TMQ.TLHGLVNKG.VKVELGIPYELWDK......PSAEVSKMHRACFTFAEEY.EERIEEWYYN..YQVDKNLLKYLCSDHYL.KDKDQ...
H2XSM5_CIOIN/32-191                 SCE..VCKYF....VNELQDRLDETGKSKE...ILRTGHGLD....PKKRKKIAYKTSE........LRLVDAMEG..IC.ERILQ.YNVHKERKGSL........RFAKGRSE.....................TME.TLQGLVAKG.VKVDLGIPYDLWDE......PSVEVTLMKKQCERMLEEY.EDTIEDWYFN..KQSSKDLLSYLCKENVL.NKTNQAC.
A7SG92_NEMVE/48-204                 KCQ..VCRLM....VSELLERLKITNYKET....LNKGYGLD..LGEDPRLQIHYHTSE........LRLADVLDD..LC.DRVKL.Y..RARAGPAF........PYIKGAKS.....................HLREAMDDLAARSKVGLKFHVPDDVIED......YTYEVVRMKFQCVHMLELF.EEVIEEWYFE..HQ.DQDLMTWLCRERVLKIDE.....
A0A068Y828_ECHMU/27-174             TCE..VCKLF....CHEFMLRYNATDSSAM..........LD..FHGASNKKVPYSTSE........LRLTEIMQDPDLC.TSMLQ.YRLHNERKDST........RFQKSRPQ.....................TFE.TLRQLVERG.VDVKLDIPLSLWDS......PSVEISMLKEKCEQLVVEY.ESLIEEWFFD..HHDETSIVDYLCRQR...........
W5N9H4_LEPOC/26-180                 KCE..VCQYCCVCDSVVLQASLDKTSRSKE...VLELGEVLD...TGKRKRKIKYNTSE........TRLAEAIDN..IC.QGILE.YNVHAERPGSL........RYAKGTSE.....................TMM.TLKNLVNKG.VKVELGLPYELWDE......PSVEVSDMKKQVQTMLEQY.EDVVEDWYFH..HQ.DQRLETFLCEKR...........
I3KRZ0_ORENI/26-185                 KCE..VCKFL....TVELQDALEKTARSRE...VLEVGEVLD...TGKRKKKIKYNTSE........TRLTEAVDN..IC.ERILE.YNVHAERPGSL........RYAKGSSQ.....................TMT.TLKNLVHKG.VKVDLGMPYELWDE......PSVEVTDMKKQCETMLEQY.EDVVENWYFH..HQ.DQRLENFLCENHVL.ETSEQEC.
CNPY4_DANRE/26-185                  KCE..VCKLL....TVELQDALDKTGRSKE...VVELGEVLD...TGKRRRKIKYNTSE........MRLTEAMDN..IC.ERILQ.YKVHAERPGSL........RYAKGTSQ.....................TMN.TLKNLVEKG.VKVELGVPYELWDE......PTVEVAELKRQCETMLEEH.EEVVEDWYFH..HQ.DKGLERFFCEAHVL.KDSDQEC.
F6SV63_ORNAN/131-288                ....AVCKYL....SSELQGELGRSSGSRE...VLELGQVLD...TGGRKRRVPYSTSE........TRLEEALDH..LC.DRILD.YKVHAERKGSL........RYAKGQSE.....................TMT.TLKNLVQRG.VKVDLGIPPELWDE......PSVEVTHLKQQCETMLERF.EDVVEDWYFR..HQ.GEPLQAFLCEGHVL.KEGETAC.
G3WD91_SARHA/42-203                 KCEDTVCKIL....TVELQGELNRSSRSRE...LLELGQVLD...TGKRKRQIPYSTSE........IRLEEALEN..LC.EQILD.YSVHAEHKGSL........RYAKGQSE.....................TMA.TLKGLVQKG.VKVDLGIPLEMWDE......PSVEVSFLKKQCELMLEKF.EDVIEDWYFH..HQ.ELPLQQFLCEGHVL.AKEEKDC.
G5AN18_HETGA/36-195                 KCE..VCKLL....SMELQEKLSHTGRSRE...VLELGQVLD...TGKRKKHVPYTISE........TRLEEALEN..LC.ERILD.YSVHAERKGSL........RYAKGQSQ.....................TMA.TLKGLVQKG.VKVDLGIPLELWDE......PSVEVTFLKKQCETMLEEY.EDVLGDWYFH..HQ.EQPLQHFLCEGHVL.PAAETAC.
H3A4A3_LATCH/27-186                 KCE..VCKYL....TLELETALEKTKHSKE...VLELGQVLD...SGVRKRKIQYQTSE........MRLAEAMDN..IC.ERILE.YNVHAERPGSL........RFAKGQSE.....................TMA.TLKNLVNKG.VKVELGIPYELWDE......PSVEVTDMKKQCETMLEVH.EEVVEDWYFH..HQ.DQKLETFLCVNHAL.KNDEKEC.
C3Y9Y9_BRAFL/43-203                 KCE..VCKYL....SVELEHRLDETGRSKE...QIELGHVLD...RGERKRKINYHTSE........LRLVEAMDD..IC.ERILE.YNVHAERDGSN........RYAKGMSE.....................TFQ.TLHGLVNKG.VKVELGIPYDMWDT......PSAEVTVMKKQCESMLESH.EDEIENWYYN..LQGEKSLLQHFCADTVL.GKRETEC.
CNPY3_XENTR/27-187                  KCE..VCKYV....ALELKSSFDETSRTRE...LIDTRYGFL..EDDKKAKKIKYTNSD........IRLIEVTEG..LC.SRLLE.YNLHKERSGSN........RFAKGMSE.....................TFQ.TLHHLVHKG.VKVVMDIPYELWNE......TSAEVADMKKQCDVMMETY.EDVIEDWYRH..HQ.EADLTEFLCARHVL.RGQDQSC.
M4A994_XIPMA/33-192                 RCE..VCKFV....SIEMKSAFEETGKTKA...VIESNYNFI...DGKGAPPVKYVKSD........LRFIEVVEN..VC.QRLLE.YNLHKERSGSN........RFAKGMSE.....................TFS.TLHGLVHKG.VKVVMDIPYELWNE......TSAEISDLKKQCDVMVEEY.EDVIEDWYKG..NQ.EEDLTTYLCEKHVL.KGGDKAC.
CNPY3_DANRE/31-187                  KCE..VCKFV....SIEMKSAFDETGKTKE...VIDTNYRFL...DDKGAPPIKYVKSD........IRFIEVTEN..VC.SRIMQ.YNLHKERDGSN........RFAKGMSE.....................TFS.TLHNLVNKG.VKVVMDIPYELWNE......TSAEVADLKKQCDVMVEQY.EDVIEDWYKG..SQ.EEDLTTYLCEKHVL.KGQD....
G1QXD3_NOMLE/47-164                 KCE..VCKYV....AVELKSAFEETGKTKE...VIGTGYGIL...DRKASG.VKYTKSD........LRLIEVTET..IC.KRLLD.YSLHKERTGSN........RFAK......................................................................CDVLVEEF.EEVIEDWYRN..HQ.EEDLTEFLCANHVL.KGKDTSC.
CNPY3_MOUSE/48-206                  KCE..VCKYV....AVELKSAFEETGKTKE...VIDTGYGIL....DGKGSGVKYTKSD........LRLIEVTET..IC.KRLLD.YSLHKERTGSN........RFAKGMSE.....................TFE.TLHNLVHKG.VKVVMDIPYELWNE......TSAEVADLKKQCDVLVEEF.EEVIEDWYRN..HQ.EEDLTEFLCANHVL.KGKDTSC.
E0VTA5_PEDHC/31-188                 KCE..VCKIV....AIELSSKLKETGKTHE...VIETGYSLD....ETKKKKTKYRTSE........LRLLETLDN..IC.ERILQ.YNIHKERQDST........RFAKGMSQ.....................TFQ.TLHGLVNKG.VKVELGMPYELWDK......PSAEITNMKTQCESLIEDY.ENAIEQWYYN..HQQSVSLEKYLCSDLVLKNDSD....
H9J1K3_BOMMO/176-336                RCE..VCKIL....ATELQNRLEETGKVHE...VIEIGYSLD...DVQPKKKTKYQKSE........LRLIESLEG..VC.DRILE.YNIHKERSDST........RFAKGMSQ.....................TFK.TLHGLVDKG.VKVDLGIPLELWDK......PSAEITHMKTQCESLLEEN.EIAVEDWYWN..HQGKEDLKIYLCTKHAL.KGVDDSC.
T1KFJ8_TETUR/41-190                 QCE..ACKYF....VTELEERLKETGKSHD...VIEVGYSID....SKQKKRKKYQQSE........LRLVESLDG..IC.ERLLE.YNIHKERKDST........RFAKGMSQ.....................TFQ.TLHGLVEKG.VKVDLGIPYELWDK......PSAEVTNLKTQCELLLEKH.EDDVEDWYWN..HQ.DESLTKFLCIDR...........
B7Q9D0_IXOSC/47-195                 KCE..VCKYL....AVELEASLGETGRTHD...VIETGYEFG.....KPKKRKKYAVSE........LRLVETLDG..VC.DRLLQ.YNVHKERKDST........RFAKGTSN.....................TFK.ALNNLVAKG.VKVDLGIPHELWDT......PSAEVTNLKTQCEALLEEH.EADIEAWYFG..KQ.DRALSDYLCRGR...........
D6WZ22_TRICA/30-190                 RCE..VCKIL....AIELESRLEETGKTHD...VIETGYEVD...DVKPKKKKEYKKSE........LRLVESLDG..VC.ERILE.YNIHKEREDST........RFAKGMSQ.....................TFQ.TLHGLVDKG.VKVELGIPYELWDK......PSVEVTNMKTQCETLLEQN.EGDIEEWYFH..HQGKQSLKKYLCEERAL.RNEDTSC.
C4WUW6_ACYPI/31-188                 KCE..VCKIL....AEELEGRLLETGKTSE...YLEIGYSID.....LPKKKKEYKKSE........LRLVESLDG..LC.ERILK.YNIHKERTDST........RFAKGMSQ.....................TFQ.TLHGLVNKG.VKVELGIPYELWDK......PSVEITNMKTQCEDLLETY.ESDIEQWYFN..DQ.AESLRSYLCKDRAL.KDSDQTC.
A0A158NLW0_ATTCE/33-190             KCE..VCKVL....ATELEARLDETGKTND...VLEIGYSVD...DVVPKKKKEYKKSE........LRLVESMEN..VC.ERILE.YNIHKERTDST........RFAKGMSQ.....................TFK.TLHGLVDRG.VNVDLGIPYELWDK......PSVEITTLKTQCEDLLENY.EADIEDWYYN..HQREISLIRYLCSERAL.KGQN....
B4QQC7_DROSI/35-196                 RCE..ACKIL....ATELEARLGETGKSHD...VIEIGYSVD...DVKPKKRTEYRRSE........LRLLESLEN..VC.ERVLE.YNLHKERSDST........RFAKGMSQ.....................TFQ.TLHGLVDKG.VKVDLGIPYELWDK......PPVEVTQMKTQCENLLEEY.EETISDWYFK..HQDEKSLKKHLCEDHVLKKKAEREC.
Q17CU1_AEDAE/31-191                 KCE..ACKIL....ATELQARLSETGKSHD...VIELGYSVD...DVKPKKRTEYRRSE........LRLLESMEN..VC.DRILE.YNIHKERKDST........RFAKGMSQ.....................TFQ.TLHGLVNKG.VKVDLGIPYELWDK......PSAEITQMKTQCETMVENF.EDVIEKWYFN..KQEEIPLIKYLCEDRVL.RANDHQC.
W4YKH6_STRPU/38-196                 KCE..VCKFV....ATELQDTMADTGKTSD...VLHLGYRID.....QPKRHIKYRLSE........LRLLETLDE..VC.PKILQ.YNIHAERHNSR........RFSKGMSE.....................TMG.TLHGLVDKG.VKVELGIPLEMWDE......PSAAVTKMKQYCDTMVEQH.EEAIENWFFK..TDQEKPLLEYLCRERVL.PKEESEC.
F6PQZ3_CIOIN/58-219                 NCH..VCRLM....VEEIKHSLKGEADLTE..............EQLKEKKRKDRRKSKAERKREKALPMLVAIEE..VC.NSMLG.YLPQQADKT.K........FRYVKSH......................DLK.EVNSLIKSQ.EENDNAADELARKYD...AYRHPETNRLLAMCDEIINRE.ENNLMRWNTN...EEKEDLFDYLCRNRVFTVEDSDEC.
A7RSQ2_NEMVE/45-188                 QCD..ACTAI....AHRRFIHICDSKICKSSVAIRVMNVALHKEEAKRPSL.KGKPVPE........SVYVDAIEG..VCSSKSWEDYGIKTVNG......................................................INRISGEGLEAKDVPGMMQGGGKWPGRLMSKCEGMVGDIGEDKLYEKFRE.....DGDLHKYLCTEF......SQDC.
Q381R4_TRYB2/53-198                 DCS..ACIAFAGHLGRRMNESIRYGGRGGA...TFLSSHRL...GKDNKLKRRDYATSE........LRGAEVLEK..ICNDSLFDDYALHFRADMRI........RVYDN...................................GE.SEYPLAQHYSKEDSR...ILKAVKTKAVHVFCTRVMDEE.EDAMTSLVRE..VELLSELEQRLCG.............
Q4Q576_LEIMA/60-236                 DCS..ACITVARTLFERLNQTLAENPS......TYLISHRL...GKKNQLRRRQYRNSE........LLVTEVMEN..VCTSYKNDARLLRLHPKSKV........RLYHQQVFGDTRLGVRHALREDEVYPADADPA.AWAEKLDGQ.LYPIARLYSRRDADA...LQGLQSLSATPTMCALLVEEF.EDEIESLVKS..VRSLEETEHSLCG.............
E9H737_DAPPU/39-185                 RCM..VCKAL....VDEVEIAVDRVDPHKK...VDMGSFRLDGKGNVKQNL.VPYARSQ........LFLSEVMDK..VC.PMFRN.YVVANYKATGR........PTLLRIETPDGK.............GMNPEMS.NVNIVPNPE.VN.......................EQLSSYCQGLVEEY.EDEIVSMFAK..S..EKQLHQKLCVQL......AEVC.
B4MQX2_DROWI/26-172                 KCH..VCKAV....VTELEEAISKEDANKK...VDVSGFRLDAQGNSISKR.VLLIKSE........MFLTELMEK..IC.DKMDD.YLKATYKSNGK........FTLLKMIINGK...............MNPESS.LVDFVQDGD.LN.......................KSLGHFCNEILEDH.EEAFLKAFQA..EEVGSDLDIRICSEH......AKYC.
Q16KG3_AEDAE/37-184                 KCL..VCKAT....MNEMELAVSKVDPKKK...IDVGDYRLDATGDSKKKKTILYAKSE........MYLTELMES..VC.DRMDD.YAKARYKKNGR........PVVLKMMTETG...............MNPEMS.DVDFVQEGD.LN.......................KSLKHLCLEVVEDH.EEDILKMFQQ..EDVVKDTDIRLCSQV......ANIC.
Q7PPM0_ANOGA/42-188                 KCL..VCKAS....MAEMELAASKVDPNKK...VEVGDYRLDTTGESKKKKKILYAKSE........MYLTEMMET..VC.DRMDD.YAKARYKKTGR........PVVLKMMTDGG...............MNPDMA.NVNFVQEGD.LN.......................KTLKHLCLEIVETY.DEDIIRMFQE..E.VVKDTDIRLCSQV......AKYC.
D6WRV5_TRICA/29-171                 .....VCKVS....LDELHKAVNKIDPTKT...VDVGGYRLDSDGNYRHKS.VSQAKSE........VHLSEMIED..IC.TKMDD.YVRATWKSNGT........LTLLKLITEDG..............KMNNDMS.EVNLIQDDD.LN.......................KSLKYYCEGIMEEM.EENIIKHFQS...G.TEDVDKKVCVEE......SAIC.
E0VAC6_PEDHC/25-170                 KCL..VCRAT....IDEMIKEINKVNPKKK...IQVGGYRLDTDGKLQEKV.VSFARSG........MHLSELMDT..IC.KSMDN.YVRATKKETGE........LVLIKLMADDG..............KMNADIS.SVDIIQDSD.LN.......................KSLEFYCEGIVEEF.EDEIYYELKS..P..TDDPVNEICTSA......SNLC.
K7IYX5_NASVI/27-171                 RCL..VCRTI....VDEFKYEVSKIDPTKE...IEIGQYRLDSKGNTVHKK.VPLSMSE........VHLSDLLDS..IC.KRMED.YVRATYKSNGK........LTLLKLMSDGG...............VNPLIN.EVDIVQDGD.LN.......................KSLEYFCTDIVNEH.EETFIEVISK..K..IKNPKAEICTEA......AEYC.
C4WRR6_ACYPI/26-171                 KCE..VCCRL....VEEIQRNVSSVEAANI...VQVSNFRLDGNGDQIKQT.VPLARTQ........LYLTEVMDS..VC.EKMND.YVRATYKKNGT........LTVMPLILDGK...............MNPLMS.EVDVVQDSD.LN.......................KSLQYFCEEIVDDI.EEDLINIIKS..ED.DDHLVHSICTNV......MHLC.
A0A088AH64_APIME/33-178             KCL..VCRST....MKEIEGELAKIDPARE...IEIGNYRLDAQGNIIHKK.IPLAQSE........VYVSDILDN..IC.EKMSD.YVRATYKSNGE........LTILNLISPSG..............AMNPEMS.KVDIIQDDD.LN.......................KSLKYYCEGIVEEF.EDSIISLFIH..K..KNDINEQLCTNI......ANLC.
E2BUS3_HARSA/37-179                 .....VCRAT....MDEMEAAVSKLNPRVL...VDAGNYKMDAQGNTVQKK.VPLRKSQ........VHISDIVDD..IC.SKMKD.YVRGIKKYNKK........LTIFNIVLPSG..............GMNPEMS.KVDLIHDGD.LN.......................KSLEFYCHLVVEQL.EDDIISLYVN..D..VENKKEKLCTEH......SHIC.
A0A158NR17_ATTCE/30-175             KCL..VCRAA....MNELENEVLKANPNKL...VDVGNFRMDADGNTIHKK.VPLGRSE........THISILLDN..IC.EKLSD.YVRATRKSDNQ........LMIFNLMSPSG..............GMNPIMS.EVDIIQDGD.LN.......................KSLEHYCSTVVEEF.EEDIVSLYVD..G..ISNKKKELCTKI......SNIC.
C3YL01_BRAFL/28-173                 YCG..ACHVL....VDEIDYAIRQIDPRKT...IQVGSFRVDPKGNQKTWE.IPYARSE........VYLTELVET..VC.EKMNQ.YAQSTDPDTQK........KSYVRTSSRNG...............ETLSLS.NISM..NQD.IS.......................KALRFACESIIEDF.EDDMVKLFSKEGPK.LHELQNSLCMET......AELC.
W4XG20_STRPU/34-176                 YCG..ACQAL....ISEVEYAITQEDPHQT...ITVGSFRIDPKGEQKQKK.IPYAGSE........LHLTEVMET..VC.DKMTD.YAEKTDPETNE........KTYVRYQARNG...............EDMELI.NVSI..NLT.TG.......................KVLKVACENIIEDY.EDDVLRLYRE...K.STDIETSLCSSL......TKLC.
W5KLX1_ASTMX/28-174                 YCS..ACMAI....ADELNYTISQIDPKKT...VQVGGFRLNPDGSLQEKT.VPLAKSQ........THLSELLDE..VC.NSMSD.YALYEDPDTKE........QSYKRFAPRGND............GGNFPDFK.NFKF.AGPE.GT.......................DSLKFACETIVEEL.EDDIISLFTR...E.EKRVAKKLCSEI......SDHC.
CNPY1_DANRE/31-177                  YCS..ACMAI....ADEINYSISQTDPKKM...IHVGGFRLKPDGSLTDKK.VPLARSE........TYLTELLEE..VC.KSMSD.YALYENPDTKE........KSYKRFAPRDND............GGNFPDFK.NFKF.DGPE.SS.......................SALKFACESIVEEL.EDDIISLFAS...D.SDHVAKTLCSEV......SDHC.
H2LVG0_ORYLA/29-171                 YCS..ACRAI....VDELNYSISQVDPRKT...IDIGGFRVNPDGSVKNKQ.VPLARSE........THLGELLEE..VC.KSMSD.YALYLDPNTQQ........KQYRRFAPRSTGA...........DGGFPDLK.NFQF.DGPE.AS.......................TGLTFACETLVEEL.EDAIISTFSK...K.ADGVEEQLCS............S
G3PN37_GASAC/29-176                 YCS..ACKAI....VDELNYSISQVDPKKT...INVGGFRLNPDGTMKDKK.VPLARSE........THLSELLDG..VC.DSMSD.YALHVDPDTQL........KQFMRFAPRSGGA...........TGDFPDFK.NFQF.DGPE.AS.......................NALKFACESVVEEL.EDDIISLFSQ...D.VEHVHQELCNRV......SGYC.
I3JTJ6_ORENI/29-177                 YCS..ACKAI....VDELNHSISLVDPKKT...INVGSFRLNPDGTMKDKK.VPFARSE........THLSELLDG..VC.NSMSD.YALYVDPVTQH........KQYRRFAPRSSAS...........TDDFPDFK.NFQF.DGPE.AS.......................NDLKFACETLVEEL.EEEIISVLSR...DRQENVHEELCSRV......SDHC.
F6WI24_XENTR/1-143                  .....ACRAL....VDELLYEIRKVNPKKT...VDVGSFRISPDGTQEQNK.VPLAKSE........LYLTEVLEE..IC.EKMND.YGLYVDPTTRE........KSYKRFAPRDNE............GIGSVDFQ.NFQF..NPE.ES.......................NSLKYACERVIEEH.EDEVLSVITK...E.SDNLADKLCTEE......TGLC.
G1KKQ7_ANOCA/36-180                 FCG..ACKAL....ADELAYDIKKIGPKRT...VNSGTYRINPDGTRGKKK.IPFAKSE........TFLTDVLEK..IC.DRMND.YQLQDDPVTQK........KIFKRYAPRKDE.............PIYAEYK.KYFF..YSD.AY.......................KPLKYACETIIEQY.EDEIFSLIAQ...E.ADFLADKLCIEK......SGLC.
G1SHL3_RABIT/35-178                 VCG..ACRAL....MDEVEYDVTKARQKKA....KVGSFRINPDGTQERRK.IPLVQSE........AFLVDLLDN..VC.ERMND.YQLKEDPVTKE........KTFTRYAPRKGD.............KVYKEYK.KFYF..YSD.AY.......................RPLKFACETIIEEY.EDEIFALIAQ...E.ARSLADRLCSEK......SGLC.
F6S160_ORNAN/20-164                 FCG..ACKAL....MDEIEYDVMKARQKKT...MVVGSFRINPDGTQQRKK.ISLAKSE........AFLTEVLEN..VC.NRMND.YKLEEDPQTKE........KSFKRFAPRKGD.............KIYEEFK.RFYF..YSD.AY.......................KPLKFACETIIEEY.EDEIYALIAQ...E.AVYLADKLCSEK......SDLC.
G3WN37_SARHA/9-150                  .....ACRAL....MDEVEYDVMKARQKKG...VRVKSYRIRPDGTQERTK.IPLAQSE........AFLTEVLET..VC.ERMND.YKLEDDSNDRP........KTFKRFAPRKGD.............KMYKEFK.RFYF..YSD.AY.......................WPLRFACEMIIEEY.EDEIFSLIAQ...E.ADHLADKLCTEK......SDLC.
L8YCG7_TUPCH/27-171                 HCG..ACRAL....VDELEWEIAQVDPKKT...IQMGSFRINPDGSQSVVE.VPYARSE........AHLTELLEE..VC.DRMKE.YGEQIDPSTHR........KNYVRVVSRNGD.............SNELDLQ.GIRI..DSD.IS.......................GTLKFACESIVEEY.EDELIEFFSR...E.ADNVKDKLCSKR......TDLC.
G1LSX8_AILME/28-167                 HCG..GCRA.......ELDWETAQVDPKKT...IRTGSFQINPDGHQSVVE.VTYARTE........AHLTEQLLE..VC.DQMKE.HGDQTDPPTHR........KNYDCVGGRNGE.............SNELDLQ.AIWT..DSD.IR.......................GTPKFACENIVEEQ.ENELTEFFSQ...E.ANSMNNKFCRRQ......TD...
Q28FU2_XENTR/31-173                 HCG..ACRAL....VDELEWEISQVDPKKT...IQKGSFRINPDGTQSVIE.VPYARSE........AHLMEVLEQ..IC.EKMTE.YGEKIDPSTDR........KIYVRVVSRDG...............KKMDAS.GTNI..DIE.VT.......................SNLKFTCERIVEEY.EDELIEFFSH...E.RENVKDKLCSKR......TDLC.
A0A2H2HY78_CAEJA/28-166             ECG..ACSLL....VTHFELKIAAVDPNKK...IEVGSFRVSPTGEQKGLKEIGYARSE........THLTEIIEH..VC.DEAKN.YKLVMNTNTGK........SVYVH...........................................KDVSQHLDGD...ESA.KMRSRLQNACNDFIDAN.EDELLHFLKS....AHEKPVKEFCHKT......IGVC.
Q95QN1_CAEEL/25-162                 ECG..ACSLL....VTHFELKIAAVDPKKK...IEVGSFRVSPTGDQKGLKEIGYARSE........SHLTEIIEH..AC.DDAKH.YKLVVNTITGK........SVYVH............................................NDATHLKGD...ESP.KMRYNLQNACNDFIDSH.EDELLGFLKT....AHQDPVKQFCQGE......MGAC.
U3JCI6_FICAL/44-186                 HCG..ACRAL....VDELEWEIAQVDPRKT...IQMGSFRINPDGSQSVVA.VPYARSE........AHLTELLER..VC.EKMKE.YGEKVDPATHR........KSYVRVISHDG...............TKMDLS.GLKF..DGD.VT.......................SSLKFACESIAEEY.EDELIEFLSH...E.AENVKDRLCSKR......TDLC.
H3CNP8_TETNG/31-173                 KCG..ACRAL....VDEMEWAISQVDPKKM...IQTGSFRINPDGSQSIRE.VPLARSE........GHLLELMEG..VC.ERMED.YGELADASTHR........KSYIRVRSRGG...............EAMDLS.QATL..DSR.VT.......................ASLKFACETIVEQH.EDEIIEFFAH...E.TDNVKDKLCSKR......TDLC.
H2Y6U3_CIOSA/25-179                 YCG..TCKAI....MSEVEHSISQIDPNKK...IDVGSFRVDPNGKTRTIQ.KPYARSE........AHLTGLLET..VC.NEVSENYVESKDAESGK........MRLKRMVTHDGK............MSSDVDFQ.SLME..NSK.NSDAPPD...............AKTKKVKFACESIIEDY.EDEILHHFKN...E.HNNADLKICAEL......AEYC.
K1RA73_CRAGI/25-167                 YCA..VCRAL....VDEVNHSISLVDSKQK...VQVGSFRVDSKGNQKVVE.VPLARSE........IHLTEVFET..IC.EKFRQ.YGNTKN.ELGK........KSVVRMVSRDG...............KPLVLK.DIHI..TME.GM.......................KLLTHTCETIAEEY.EDQIIRAFRD..GE.LAAVEQKVCGNI......AGYC.
D7UDC4_VITVI/24-164                 KCA..ACNAV....AEELEFGLSNEKPRNH...LDMRH.RLDSKGQRKGKV.IDYRVSE........LRVVELLDG..LC.EKMQD.YTLEKIDSTRR........EWVKVD.......................DWD.NITTNKQ.E.AR....................AYSKDISSYCGRLLEET.EDELADLIKKGSVK.TGEVSKVLCQDL......SKHC.
M1ALU1_SOLTU/63-203                 KCS..ACSAI....AEELEHGLLKEKPRNH...LDMRH.RLDSKGQREGKL.IDYRGSE........LRVVELLDD..LC.EKMQD.YTLEKVDSSTN........TWIKVN.......................NWD.LLKTNKQ.E.AR....................AHSKAMSSFCGRLLEQT.EDELAELIKKGSVK.VGDVTKVLCEDL......SNYC.
D7KMU1_ARALL/24-163                 KCA..ACNAV....AEELELQLLKEKPRNH...LDMRN.RLNSKGQREGKV.IDYRISD........LRVVDLLDG..LC.DRMQD.YTLQKVESKNR........QWVKVG.......................NFD.NL.TNKQ.E.AK....................AHANDISTYCGRLLEET.EDELGEVIKNGSLK.AGEVRKVLCQTL......SNHC.
I1NWL1_ORYGL/32-173                 KCA..ACKAV....AAELEIGISSEKPRNH...LDLRN.RLNSKGQREGKV.IDYRVSE........LRVVELLDG..LC.DKMQD.YTLQKLESGEK........GWVKVA.......................DWN.SFKTEKKAA.AR....................AHSKNLSSFCGRLLEET.EDELSEWIKTSSAE.SGNVSRALCEDI......SKHC.
M0S0V4_MUSAM/34-174                 KCA..ACNAV....AAEIEIGLSNEKPRNH...LDMRH.RLDSRGQREGKV.IDYRVSE........LRVVELLDG..LC.EKMQD.YTLEKLDSGEQ........AWIKVR.......................DWN.SIEGDKQ.E.AR....................AYSKDLSSFCGRLLEET.EDQLAEWIKRGSAE.SGGVSKALCQDL......TEHC.
A4RYT4_OSTLU/22-165                 KCS..ACRAV....GKSLAKALREDAESADGKVVDMRG.RLDSRGRRYGKR.ISYKVSE........LRFVELLDG..VC.DEPSR.VGKYQLHEETN........RWRIPP.........................N.PVKKIRHAR.GK....................QMKTEILGYCHRVIEES.EEALQAAVLEERLDAESNVEEFLCRNV......SKAC.
Q017C7_OSTTA/27-169                 KCS..ACRGV....GKSLADALRNDEKESEGKVVDMRG.RLDSRGKRYGKK.ISYKESE........LRFEELLEN..VC.ADDGK.VSELQFHEETA........RWRKPP.........................N.PVKKIRGAR.AK....................AMKAEIMGYCHRVIESA.EDALREAVYQSTIDG.STVEEFLCRNV......SKEC.
C1FFA2_MICCC/31-175                 KCS..ACAAV....AGQLQTALEAEKPRNH...VDLRG.RLDSKGVRYGKL.IPYDVSE........QRFTELMEG..VC.EGLGR.YTLRTVKPSEGPSAGTDVMRWENIG...........................R..VSKNPR.AK....................TLRDELNDYCHRIVEKQ.EEDLQKALYA.KELNSTNVAEKMCIQF......SGEC.
C1N2B6_MICPC/22-161                 KCS..ACEAV....ANELQAALERERPRNH...LDMRG.RIDSKGVRYGKL.IDYKISE........LRFVELLED..LC.TDVGNNFQIFDADAPKK........RWRTFA...........................KKLKIKGAR.AK....................AMRAEISGYCHRLVEEQ.EEALQAKLYA.NELNATNVDEILCVEL......SKEC.
#=GC seq_cons                       +Ct..sC+hl....ssELptplscss.p+c...l.hsua+lD..tstptK+.lsYspSE........h+LsEll-s..lC.-+hh-.Yslpp-csssp........+hh+thst.....................shp.slph..sts.lp.......................ssLKttC-sllE-a.EDsl.chahp...p.ppslpchLCpcp......sp.C.
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