Summary: Stonin 2
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Stonin 2 is involved in clathrin mediated endocytosis . It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) . In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling .
Rumpf J, Simon B, Jung N, Maritzen T, Haucke V, Sattler M, Groemping Y;, EMBO J. 2008;27:558-569.: Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity. PUBMED:18200045 EPMC:18200045
This tab holds annotation information from the InterPro database.
InterPro entry IPR022699
Stonin 2 is involved in clathrin mediated endocytosis [PUBMED:18200045]. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) [PUBMED:18200045]. In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling [PUBMED:18200045].
This entry represents the N-terminal domain of stonin-2. It is found in association with .
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Curation and family details
|Author:||Mistry J, Gavin OL|
|Number in seed:||4|
|Number in full:||64|
|Average length of the domain:||251.90 aa|
|Average identity of full alignment:||59 %|
|Average coverage of the sequence by the domain:||34.32 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 17690987 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||6|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Stonin2_N domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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