Summary: Piwi/Argonaute/Zwille siRNA-binding domain
Piwi/Argonaute/Zwille siRNA-binding domain Provide feedback
This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There is a conserved LKDIL sequence motif. There is a single completely conserved residue L that may be functionally important. This domain is part of an Argonaute protein. It is an siRNA binding domain.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR021103
This entry represents a siRNA binding repeat found in bacterial and archaeal proteins, which is approximately 50 amino acids in length. There is a conserved LKDIL sequence motif and a single completely conserved residue L that may be functionally important [PUBMED:15800637].
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Author:||Mistry J, Gavin OL|
|Number in seed:||10|
|Number in full:||42|
|Average length of the domain:||45.80 aa|
|Average identity of full alignment:||56 %|
|Average coverage of the sequence by the domain:||46.23 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PAZ_siRNAbind domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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