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0  structures 128  species 2  interactions 417  sequences 28  architectures

Family: Dsh_C (PF12316)

Summary: Segment polarity protein dishevelled (Dsh) C terminal

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Segment polarity protein dishevelled (Dsh) C terminal Provide feedback

This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with PF00778 PF02377 PF00610 PF00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).

Literature references

  1. Klingensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ;, Mech Dev. 1996;58:15-26.: Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. PUBMED:8887313 EPMC:8887313


This tab holds annotation information from the InterPro database.

InterPro entry IPR024580

Wnt proteins constitute a large family of secreted signalling molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Wg) (Drosophila) [PUBMED:9891778]. It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals. Wnt signalling has been implicated in tumourigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease [PUBMED:10967351].

Wnt signal transduction proceeds initially via binding to their cell surface receptors - the so-called frizzled proteins. This activates the signalling functions of B-catenin and regulates the expression of specific genes important in development [PUBMED:10733430]. More recently, however, several non-canonical Wnt signalling pathways have been elucidated that act independently of B-catenin. In both cases, the transduction mechanism requires dishevelled protein (Dsh), a cytoplasmic phosphoprotein that acts directly downstream of frizzled [PUBMED:12072470]. In addition to its role in Wnt signalling, Dsh is also involved in generating planar polarity in Drosophila and has been implicated in the Notch signal transduction cascade. Three human and mouse homologues of Dsh have been cloned (DVL-1 to 3); it is believed that these proteins, like their Drosophila counterpart, are involved in signal transduction. Human and murine orthologues share more than 95% sequence identity and are each 40-50% identical to Drosophila Dsh.

Sequence similarity amongst Dsh proteins is concentrated around three conserved domains: at the N terminus lies a DIX domain (mutations mapping to this region reduce or completely disrupt Wg signalling); a PDZ (or DHR) domain, often found in proteins involved in protein-protein interactions, lies within the central portion of the protein (point mutations within this module have been shown to have little effect on Wg-mediated signal transduction); and a DEP domain is located towards the C terminus and is conserved among a set of proteins that regulate various GTPases (whilst genetic and molecular assays have shown this module to be dispensable for Wg signalling, it is thought to be important in planar polarity signalling in flies [PUBMED:12072470]). Therefore the requirement of these domains for distinct signaling pathways varies: the DIX domain is essential for B-catenin activation, the DEP domain is implicated in the activation of the JNK pathway, while the PDZ domain is required for both [PUBMED:9867820].

This entry represents a domain found in the C-terminal of Dsh proteins.

Domain organisation

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Alignments

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  Seed
(18)
Full
(417)
Representative proteomes UniProt
(701)
NCBI
(1618)
Meta
(0)
RP15
(42)
RP35
(122)
RP55
(271)
RP75
(336)
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(18)
Full
(417)
Representative proteomes UniProt
(701)
NCBI
(1618)
Meta
(0)
RP15
(42)
RP35
(122)
RP55
(271)
RP75
(336)
Alignment:
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  Seed
(18)
Full
(417)
Representative proteomes UniProt
(701)
NCBI
(1618)
Meta
(0)
RP15
(42)
RP35
(122)
RP55
(271)
RP75
(336)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PFAM-B_3969 (release 23.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Assefa S , Gavin OL
Number in seed: 18
Number in full: 417
Average length of the domain: 175.50 aa
Average identity of full alignment: 55 %
Average coverage of the sequence by the domain: 27.37 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.3 22.3
Trusted cut-off 22.7 22.7
Noise cut-off 22.0 22.1
Model length: 208
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Interactions

There are 2 interactions for this family. More...

Adap_comp_sub Adap_comp_sub