Summary: Lymphocyte signaling adaptor protein
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Lymphocyte signaling adaptor protein Provide feedback
This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with PF07647 PF07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.
Beer S, Simins AB, Schuster A, Holzmann B;, Biochim Biophys Acta. 2001;1520:89-93.: Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells. PUBMED:11470164 EPMC:11470164
This tab holds annotation information from the InterPro database.
InterPro entry IPR021090
This entry represents eukaryotic proteins that are typically between 144 and 156 amino acids in length. The entry is found in association with , . There is a conserved LGKK sequence motif. SAM/SH3 domain-containing proteins contain a Src homology 3 domain and a sterile alpha motif, suggesting that they may function as a signaling adaptor protein in lymphocytes [PUBMED:11470164].
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Curation and family details
|Number in seed:||34|
|Number in full:||278|
|Average length of the domain:||144.40 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||23.62 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SLY domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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