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0  structures 703  species 0  interactions 1218  sequences 11  architectures

Family: MDM10 (PF12519)

Summary: Mitochondrial distribution and morphology protein 10

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Mitochondrial distribution and morphology protein 10 Provide feedback

MDM10 is a family of eukaryotic proteins that forms a subunit of the SAM complex for biogenesis of beta-barrel proteins, though not porins, into the outer mitochondrial membrane.

Literature references

  1. Sogo LF, Yaffe MP;, J Cell Biol. 1994;126:1361-1373.: Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane. PUBMED:8089171 EPMC:8089171

  2. Boldogh I, Vojtov N, Karmon S, Pon LA;, J Cell Biol. 1998;141:1371-1381.: Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p. PUBMED:9628893 EPMC:9628893

  3. Hanekamp T, Thorsness MK, Rebbapragada I, Fisher EM, Seebart C, Darland MR, Coxbill JA, Updike DL, Thorsness PE;, Genetics. 2002;162:1147-1156.: Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae. PUBMED:12454062 EPMC:12454062

  4. Meisinger C, Wiedemann N, Rissler M, Strub A, Milenkovic D, Schonfisch B, Muller H, Kozjak V, Pfanner N;, J Biol Chem. 2006;281:22819-22826.: Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10. PUBMED:16760475 EPMC:16760475

  5. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P;, Science. 2009;325:477-481.: An ER-mitochondria tethering complex revealed by a synthetic biology screen. PUBMED:19556461 EPMC:19556461


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR027539

Mitochondrial distribution and morphology protein 10 (Mdm10) is a component of the ERMES/MDM complex (composed of MMM1, MDM10, MDM12 and MDM34), which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex) [ PUBMED:15239954 ]. It functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins [ PUBMED:17410204 , PUBMED:19556461 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(57)
Full
(1218)
Representative proteomes UniProt
(1827)
RP15
(184)
RP35
(533)
RP55
(857)
RP75
(1224)
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PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(57)
Full
(1218)
Representative proteomes UniProt
(1827)
RP15
(184)
RP35
(533)
RP55
(857)
RP75
(1224)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(57)
Full
(1218)
Representative proteomes UniProt
(1827)
RP15
(184)
RP35
(533)
RP55
(857)
RP75
(1224)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: DUF3722;
Type: Family
Sequence Ontology: SO:0100021
Author: Gavin OL
Number in seed: 57
Number in full: 1218
Average length of the domain: 264.40 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 97.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.1 25.0
Noise cut-off 24.9 24.9
Model length: 464
Family (HMM) version: 10
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
O13814 View 3D Structure Click here
P18409 View 3D Structure Click here
Q59LL4 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;