Summary: Microcystin synthetase C terminal
Microcystin synthetase C terminal Provide feedback
This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with PF08242 PF00501. There is a conserved YAN sequence motif. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases. This family is made up of the C terminal of microcystin synthetase, one of the proteins involved in this synthesis pathway.
Fewer DP, Tooming-Klunderud A, Jokela J, Wahlsten M, Rouhiainen L, Kristensen T, Rohrlack T, Jakobsen KS, Sivonen K;, Microbiology. 2008;154:1007-1014.: Natural occurrence of microcystin synthetase deletion mutants capable of producing microcystins in strains of the genus Anabaena (Cyanobacteria). PUBMED:18375794 EPMC:18375794
This tab holds annotation information from the InterPro database.
InterPro entry IPR022583
This domain of unknown function is found in cyanobacteria and is approximately 40 amino acids in length. It is found in association with , , , and and contains a conserved YAN motif. This region is found in microcystin synthetase, which is one of a number of proteins involved in microcystin toxin synthesis [PUBMED:12700256]. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases [PUBMED:18375794].
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Curation and family details
|Number in seed:||2|
|Number in full:||2|
|Average length of the domain:||41.00 aa|
|Average identity of full alignment:||49 %|
|Average coverage of the sequence by the domain:||1.47 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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