Summary: Suppressor of cytokine signalling
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This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with PF07525 PF00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.
Jin HJ, Shao JZ, Xiang LX, Wang H, Sun LL;, Mol Immunol. 2008;45:1258-1268.: Global identification and comparative analysis of SOCS genes in fish: insights into the molecular evolution of SOCS family. PUBMED:18029016 EPMC:18029016
This tab holds annotation information from the InterPro database.
InterPro entry IPR022252
Suppressors of cytokine signaling (SOCS) proteins play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms. They share a similar domain organisation, with a central SH2 domain and a conserved C-terminal SOCS box. In contrast, the N-terminal domains vary in length and amino acid sequence. In the case of SOCS4-7, the N-terminal domain accounts for a large proportion of the protein [PUBMED:22423360].
This entry represents a conserved region in the N-terminal domains of SOCS4 and 5. This domain is approximately 60 amino acids in length. It is found in association with , .
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Gladomain, followed by two consecutive
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||12|
|Number in full:||187|
|Average length of the domain:||53.10 aa|
|Average identity of full alignment:||52 %|
|Average coverage of the sequence by the domain:||11.16 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SOCS domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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