Summary: Central kinetochore-associated
Central kinetochore-associated Provide feedback
This is a family of proteins integrally involved in the central kinetochore. Slk19 is a yeast member and it may play an important role in the timing of nuclear migration. It may also participate, directly or indirectly, in the maintenance of centromeric tensile strength during mitotic stagnation, for instance during activation of checkpoint controls, when cells need to preserve nuclear integrity until cell cycle progression can be resumed .
Zhang T, Lim HH, Cheng CS, Surana U; , J Cell Sci. 2006;119:519-531.: Deficiency of centromere-associated protein Slk19 causes premature nuclear migration and loss of centromeric elasticity. PUBMED:16443750 EPMC:16443750
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024312
This is a family of proteins integrally involved in the central kinetochore. Slk19 is a yeast member and it may play an important role in the timing of nuclear migration. It may also participate, directly or indirectly, in the maintenance of centromeric tensile strength during mitotic stagnation, for instance during activation of checkpoint controls, when cells need to preserve nuclear integrity until cell cycle progression can be resumed [PUBMED:16443750].
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||19|
|Number in full:||220|
|Average length of the domain:||69.40 aa|
|Average identity of full alignment:||44 %|
|Average coverage of the sequence by the domain:||9.28 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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