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0  structures 117  species 0  interactions 201  sequences 7  architectures

Family: GHBP (PF12772)

Summary: Growth hormone receptor binding

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Growth hormone receptor binding Provide feedback

Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme) [1,2]. Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone [3]. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage [4].

Literature references

  1. Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI;, Nature. 1987;330:537-543.: Growth hormone receptor and serum binding protein: purification, cloning and expression. PUBMED:2825030 EPMC:2825030

  2. Schantl JA, Roza M, Van Kerkhof P, Strous GJ;, Biochem J. 2004;377:379-384.: The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE). PUBMED:14519102 EPMC:14519102

  3. Gonzalez L, Curto LM, Miquet JG, Bartke A, Turyn D, Sotelo AI;, Growth Horm IGF Res. 2007;17:104-112.: Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver. PUBMED:17321774 EPMC:17321774

  4. Okada S, Kopchick JJ;, Trends Mol Med. 2001;7:126-132.: Biological effects of growth hormone and its antagonist. PUBMED:11286784 EPMC:11286784


This tab holds annotation information from the InterPro database.

InterPro entry IPR025871

Growth hormone receptor binding protein is produced either by proteolysis of the growth hormone receptor (GHR) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme) [PUBMED:2825030, PUBMED:14519102].

Growth hormone (GH) binding to GH receptor is the initial step that leads to the physiological functions of the hormone [PUBMED:17321774]. The biological effects of GHBP are determined by the serum levels of GH, which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage [PUBMED:11286784].

Domain organisation

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Alignments

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(14)
Full
(201)
Representative proteomes UniProt
(2791)
NCBI
(2988)
Meta
(0)
RP15
(15)
RP35
(59)
RP55
(133)
RP75
(178)
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  Seed
(14)
Full
(201)
Representative proteomes UniProt
(2791)
NCBI
(2988)
Meta
(0)
RP15
(15)
RP35
(59)
RP55
(133)
RP75
(178)
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  Seed
(14)
Full
(201)
Representative proteomes UniProt
(2791)
NCBI
(2988)
Meta
(0)
RP15
(15)
RP35
(59)
RP55
(133)
RP75
(178)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download   Download   Download    

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Seed source: Pfam-B_7 (release 24.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Coggill P
Number in seed: 14
Number in full: 201
Average length of the domain: 257.90 aa
Average identity of full alignment: 46 %
Average coverage of the sequence by the domain: 47.80 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.3 21.3
Trusted cut-off 21.4 21.9
Noise cut-off 20.4 20.5
Model length: 300
Family (HMM) version: 7
Download: download the raw HMM for this family

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