Summary: Micro-tubular organiser Mto1 C-term Mto2-binding region
Micro-tubular organiser Mto1 C-term Mto2-binding region Provide feedback
The C-terminal region of the micro-tubular organiser protein 1 (mto1) is the binding domain for attachment to Mto2p.The full-length Mto1 protein is required for microtubule nucleation from non-spindle pole body MTOCs in fission yeast . The interaction of Mto2p with this region of Mto1 is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis .
Sawin KE, Lourenco PC, Snaith HA;, Curr Biol. 2004;14:763-775.: Microtubule nucleation at non-spindle pole body microtubule-organizing centers requires fission yeast centrosomin-related protein mod20p. PUBMED:15120067 EPMC:15120067
Venkatram S, Jennings JL, Link A, Gould KL;, Mol Biol Cell. 2005;16:3052-3063.: Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring. PUBMED:15800064 EPMC:15800064
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This tab holds annotation information from the InterPro database.
InterPro entry IPR024545
This domain occurs at the C terminus of microtubule organising proteins in both budding and fission fungi. In Schizosaccharomyces pombe it has been shown to interact with the Mto2p protein, an interaction which is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis [PUBMED:15120067, PUBMED:15800064].
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Curation and family details
|Seed source:||Pfam-B_28820 (release 24.0)|
|Author:||Wood V, Coggill P, Eberhardt R|
|Number in seed:||9|
|Number in full:||126|
|Average length of the domain:||50.50 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||5.17 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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