Summary: SUZ-C motif
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The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.
Song MH, Aravind L, Muller-Reichert T, O'Connell KF;, Dev Cell. 2008;15:901-912.: The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. PUBMED:19081077 EPMC:19081077
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024642
The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins [PUBMED:19081077]. It is always found at the C terminus of the protein and appears to be required for localization of the protein to specific subcellular structures. The domain was first characterised in the C.elegans protein SZY-20 which localizes to the centrosome. This domain is widely distributed in eukaryotes.
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Curation and family details
|Seed source:||Aravind L|
|Author:||Bateman A, Aravind L|
|Number in seed:||26|
|Number in full:||299|
|Average length of the domain:||32.90 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||6.69 %|
|HMM build commands:||
build method: hmmbuild --amino -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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