Summary: Vesicle coat trafficking protein Sec16 N-terminus
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Vesicle coat trafficking protein Sec16 N-terminus Provide feedback
Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region .
Espenshade P, Gimeno RE, Holzmacher E, Teung P, Kaiser CA;, J Cell Biol. 1995;131:311-324.: Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p. PUBMED:7593161 EPMC:7593161
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This tab holds annotation information from the InterPro database.
InterPro entry IPR024468
Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. The yeast protein Sec16 plays a key role in the formation of coat protein II vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus [PUBMED:7593161].
This entry represents the N terminus of the Sec16 protein found in fungi. Over-expression of truncated mutants of only the N terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region [PUBMED:7593161].
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Curation and family details
|Author:||Wood V, Coggill P|
|Number in seed:||14|
|Number in full:||66|
|Average length of the domain:||218.80 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||12.80 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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