Summary: Flagellar protein YcgR
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Flagellar protein YcgR Provide feedback
This domain is found N terminal to PF07238. Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias . This family contains members not captured by PF07317.
Ryjenkov DA, Simm R, Romling U, Gomelsky M;, J Biol Chem. 2006;281:30310-30314.: The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria. PUBMED:16920715 EPMC:16920715
Boehm A, Kaiser M, Li H, Spangler C, Kasper CA, Ackermann M, Kaever V, Sourjik V, Roth V, Jenal U;, Cell. 2010;141:107-116.: Second messenger-mediated adjustment of bacterial swimming velocity. PUBMED:20303158 EPMC:20303158
Paul K, Nieto V, Carlquist WC, Blair DF, Harshey RM;, Mol Cell. 2010;38:128-139.: The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a "backstop brake" mechanism. PUBMED:20346719 EPMC:20346719
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This tab holds annotation information from the InterPro database.
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Curation and family details
|Author:||Mistry J, Auchincloss A|
|Number in seed:||119|
|Number in full:||585|
|Average length of the domain:||88.40 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||37.67 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the YcgR_2 domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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