Summary: Telomere stability and silencing
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Telomere stability and silencing Provide feedback
Sde2 has been identified in fission yeast as an important factor in telomere formation and maintenance. This is a more N-terminal domain on these nuclear proteins, and is essential for telomeric silencing and genomic stability.
Kim DU, Hayles J, Kim D, Wood V, Park HO, Won M, Yoo HS, Duhig T, Nam M, Palmer G, Han S, Jeffery L, Baek ST, Lee H, Shim YS, Lee M, Kim L, Heo KS, Noh EJ, Lee AR, Jang YJ, Chung KS, Choi SJ, Park JY, Park Y, Kim HM, Park SK, Park HJ, Kang EJ, Kim HB, Kang HS, Park HM, Kim K, Song K, Song KB, Nurse P, Hoe KL;, Nat Biotechnol. 2010;28:617-623.: Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. PUBMED:20473289 EPMC:20473289
Internal database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR024974
Sde2 has been identified in fission yeast as an important factor in telomere formation and maintenance. This domain is found in the N-terminal section of these nuclear proteins, and is essential for telomeric silencing and genomic stability.
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This family includes proteins that share the ubiquitin fold. It currently unites four SCOP superfamilies.
The clan contains the following 59 members:APG12 APG5 Atg8 AUX_IAA Blt1 Caps_synth_GfcC CHIPS CIDE-N Cobl CRIM DCX DIX DUF2407 DUF3534 DUF4430 DWNN FERM_f0 FERM_N Flg_new GABP-alpha IgG_binding_B Lambda_tail_I Multi_ubiq NLE NQRA_SLBB Oxidored_molyb PB1 Phenol_monoox PI3K_p85B PI3K_rbd Prok_Ub RA Rad60-SLD Rad60-SLD_2 Ras_bdg_2 RAWUL RBD SAP18 SLBB Staphylokinase Telomere_Sde2 TGS ThiS ThiS-like TmoB TUG-UBL1 Ub-Mut7C Ub-RnfH ubiquitin Ubiquitin_2 Ubiquitin_3 UBX Ufm1 UN_NPL4 Urm1 USP7_C2 USP7_ICP0_bdg YchF-GTPase_C YukD
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_2457 (release 24.0)|
|Author:||Wood V, Coggill P|
|Number in seed:||16|
|Number in full:||742|
|Average length of the domain:||144.10 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||41.66 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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