# STOCKHOLM 1.0 #=GF ID HD_3 #=GF AC PF13023.7 #=GF DE HD domain #=GF AU Mistry J;0000-0003-2479-5322 #=GF SE Jackhmmer:O25415 #=GF GA 22.50 22.50; #=GF TC 22.50 22.50; #=GF NC 22.40 22.40; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cut_ga HMM metaseq #=GF TP Domain #=GF RN [1] #=GF RM 9868367 #=GF RT The HD domain defines a new superfamily of metal-dependent #=GF RT phosphohydrolases. #=GF RA Aravind L, Koonin EV; #=GF RL Trends Biochem Sci 1998;23:469-472. #=GF DR INTERPRO; IPR006674; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC HD domains are metal dependent phosphohydrolases. #=GF SQ 186 #=GS 2004016891/30-191 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 7]' #=GS 2004047245/16-178 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 8]' #=GS ECD43324.1/17-179 DE [subseq from] hypothetical protein GOS_3471078 [marine metagenome] #=GS ECO13048.1/60-221 DE [subseq from] hypothetical protein GOS_3207846 [marine metagenome] #=GS 2004014582/14-176 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 7]' #=GS 2004215145/37-200 DE [subseq from] 'conserved hypothetical protein [O.algarvensis Delta1]' #=GS EDF86621.1/62-223 DE [subseq from] hypothetical protein GOS_880694 [marine metagenome] #=GS ECZ92015.1/29-192 DE [subseq from] hypothetical protein GOS_2096332 [marine metagenome] #=GS ECI40634.1/39-199 DE [subseq from] hypothetical protein GOS_4923647 [marine metagenome] #=GS 2004037699/21-181 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 8]' #=GS EDJ59727.1/35-197 DE [subseq from] hypothetical protein GOS_1667444 [marine metagenome] #=GS EDJ37625.1/19-182 DE [subseq from] hypothetical protein GOS_1706371 [marine metagenome] #=GS EBO59136.1/16-170 DE [subseq from] hypothetical protein GOS_8054471 [marine metagenome] #=GS ECM81083.1/21-164 DE [subseq from] hypothetical protein GOS_4927308 [marine metagenome] #=GS 2001361224/17-144 DE [subseq from] 'Predicted hydrolases of HD superfamily [Soil: Diversa Silage]' #=GS EDD28306.1/6-168 DE [subseq from] hypothetical protein GOS_1328197 [marine metagenome] #=GS EBF34560.1/38-188 DE [subseq from] hypothetical protein GOS_9612983 [marine metagenome] #=GS ECN21825.1/26-178 DE [subseq from] hypothetical protein GOS_3314184 [marine metagenome] #=GS EBV84904.1/24-142 DE [subseq from] hypothetical protein GOS_6841126 [marine metagenome] #=GS ECV10182.1/39-193 DE [subseq from] hypothetical protein GOS_2961193 [marine metagenome] #=GS 2001514866/15-154 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #3]' #=GS EDD24427.1/18-180 DE [subseq from] hypothetical protein GOS_1334373 [marine metagenome] #=GS EDE24202.1/22-159 DE [subseq from] hypothetical protein GOS_1164988 [marine metagenome] #=GS EBG37363.1/97-247 DE [subseq from] hypothetical protein GOS_9443945 [marine metagenome] #=GS 2000450180/16-170 DE [subseq from] 'Predicted hydrolases of HD superfamily [Sludge/Australian, Phrap Assembly]' #=GS EBY78793.1/24-174 DE [subseq from] hypothetical protein GOS_4432224 [marine metagenome] #=GS EDE56184.1/23-167 DE [subseq from] hypothetical protein GOS_1109258 [marine metagenome] #=GS EDA59223.1/10-145 DE [subseq from] hypothetical protein GOS_1973507 [marine metagenome] #=GS EDE46798.1/23-165 DE [subseq from] hypothetical protein GOS_1125553 [marine metagenome] #=GS EBG18030.1/10-145 DE [subseq from] hypothetical protein GOS_9476525 [marine metagenome] #=GS EBB21000.1/18-153 DE [subseq from] hypothetical protein GOS_271424 [marine metagenome] #=GS EBH79950.1/18-151 DE [subseq from] hypothetical protein GOS_9200555 [marine metagenome] #=GS 2004171367/198-377 DE [subseq from] 'conserved hypothetical protein [Anammox Bacteria]' #=GS EBX51854.1/3-140 DE [subseq from] hypothetical protein GOS_6574775 [marine metagenome] #=GS EDH30046.1/1-140 DE [subseq from] hypothetical protein GOS_630525 [marine metagenome] #=GS EBX19362.1/56-193 DE [subseq from] hypothetical protein GOS_6626192 [marine metagenome] #=GS EBP95157.1/1-137 DE [subseq from] hypothetical protein GOS_7827534 [marine metagenome] #=GS ECD88629.1/5-143 DE [subseq from] hypothetical protein GOS_5142951 [marine metagenome] #=GS ECP10116.1/11-138 DE [subseq from] hypothetical protein GOS_6339757 [marine metagenome] #=GS ECY71067.1/11-145 DE [subseq from] hypothetical protein GOS_2311400 [marine metagenome] #=GS EBK30484.1/17-153 DE [subseq from] hypothetical protein GOS_8754577 [marine metagenome] #=GS EDC51554.1/27-153 DE [subseq from] hypothetical protein GOS_1462699 [marine metagenome] #=GS ECN79300.1/17-154 DE [subseq from] hypothetical protein GOS_4502448 [marine metagenome] #=GS EDH82343.1/41-179 DE [subseq from] hypothetical protein GOS_535869 [marine metagenome] #=GS EBC02023.1/24-160 DE [subseq from] hypothetical protein GOS_137486 [marine metagenome] #=GS EBC21879.1/12-148 DE [subseq from] hypothetical protein GOS_105629 [marine metagenome] #=GS 2000101320/1-112 DE [subseq from] 'Predicted hydrolases of HD superfamily [Sludge/US, Phrap Assembly]' #=GS EBZ64328.1/3-136 DE [subseq from] hypothetical protein GOS_4506056 [marine metagenome] #=GS EDC90383.1/41-180 DE [subseq from] hypothetical protein GOS_1394186 [marine metagenome] #=GS EBN84967.1/24-161 DE [subseq from] hypothetical protein GOS_8178078 [marine metagenome] #=GS ECD52160.1/1-135 DE [subseq from] hypothetical protein GOS_3131040 [marine metagenome] #=GS EDJ34487.1/17-173 DE [subseq from] hypothetical protein GOS_1712037 [marine metagenome] #=GS EDC18192.1/17-145 DE [subseq from] hypothetical protein GOS_1521692 [marine metagenome] #=GS EBD28582.1/13-137 DE [subseq from] hypothetical protein GOS_9953925 [marine metagenome] #=GS EBW84243.1/13-146 DE [subseq from] hypothetical protein GOS_6682982 [marine metagenome] #=GS 2001443116/1-142 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #2]' #=GS EBN67446.1/39-180 DE [subseq from] hypothetical protein GOS_8206933 [marine metagenome] #=GS ECF22336.1/41-169 DE [subseq from] hypothetical protein GOS_3584286 [marine metagenome] #=GS ECG16269.1/40-180 DE [subseq from] hypothetical protein GOS_3382334 [marine metagenome] #=GS EBV34816.1/13-138 DE [subseq from] hypothetical protein GOS_6920013 [marine metagenome] #=GS ECE97094.1/8-134 DE [subseq from] hypothetical protein GOS_4559876 [marine metagenome] #=GS 2001410408/1-159 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #1]' #=GS EDB06617.1/11-145 DE [subseq from] hypothetical protein GOS_1887843 [marine metagenome] #=GS EBT94870.1/11-141 DE [subseq from] hypothetical protein GOS_7189922 [marine metagenome] #=GS EBV45475.1/11-141 DE [subseq from] hypothetical protein GOS_6903580 [marine metagenome] #=GS 2001515892/11-162 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #3]' #=GS EBU44121.1/11-155 DE [subseq from] hypothetical protein GOS_7113998 [marine metagenome] #=GS EDJ27905.1/42-192 DE [subseq from] hypothetical protein GOS_1723722 [marine metagenome] #=GS ECJ75617.1/2-149 DE [subseq from] hypothetical protein GOS_3085827 [marine metagenome] #=GS 2001429315/33-186 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #1]' #=GS EBE97563.1/3-125 DE [subseq from] hypothetical protein GOS_9673456 [marine metagenome] #=GS ECE60760.1/17-119 DE [subseq from] hypothetical protein GOS_6017704 [marine metagenome] #=GS ECK57861.1/70-188 DE [subseq from] hypothetical protein GOS_3317849 [marine metagenome] #=GS 2001496394/36-193 DE [subseq from] 'Predicted hydrolases of HD superfamily [Whalefall Sample #3]' #=GS EDC09957.1/1-125 DE [subseq from] hypothetical protein GOS_1536421 [marine metagenome] #=GS EBG15065.1/41-191 DE [subseq from] hypothetical protein GOS_9481532 [marine metagenome] #=GS ECH52038.1/14-166 DE [subseq from] hypothetical protein GOS_4931186 [marine metagenome] #=GS ECL91012.1/17-157 DE [subseq from] hypothetical protein GOS_4990325 [marine metagenome] #=GS EBU10991.1/47-132 DE [subseq from] hypothetical protein GOS_7164963 [marine metagenome] #=GS EBP64502.1/21-159 DE [subseq from] hypothetical protein GOS_7877918 [marine metagenome] #=GS ECE85580.1/3-102 DE [subseq from] hypothetical protein GOS_5021688 [marine metagenome] #=GS ECQ81757.1/1-106 DE [subseq from] hypothetical protein GOS_4153214 [marine metagenome] #=GS 2001337769/2-96 DE [subseq from] 'Predicted hydrolases of HD superfamily [Soil: Diversa Silage]' #=GS EBH89721.1/1-98 DE [subseq from] hypothetical protein GOS_9183640 [marine metagenome] #=GS ECS21942.1/11-108 DE [subseq from] hypothetical protein GOS_5577377 [marine metagenome] #=GS ECD05997.1/29-156 DE [subseq from] hypothetical protein GOS_4943928 [marine metagenome] #=GS ECE86587.1/29-159 DE [subseq from] hypothetical protein GOS_4978727 [marine metagenome] #=GS ECH48179.1/13-88 DE [subseq from] hypothetical protein GOS_5083727 [marine metagenome] #=GS EBF32245.1/8-131 DE [subseq from] hypothetical protein GOS_9616756 [marine metagenome] #=GS EBU69113.1/1-98 DE [subseq from] hypothetical protein GOS_7021131 [marine metagenome] #=GS EBU41325.1/31-173 DE [subseq from] hypothetical protein GOS_7118404 [marine metagenome] #=GS EBG71891.1/2-95 DE [subseq from] hypothetical protein GOS_9385813 [marine metagenome] #=GS 2000603530/16-84 DE [subseq from] 'Predicted hydrolases of HD superfamily [Sludge/Australian, Phrap Assembly]' #=GS EBF39781.1/16-149 DE [subseq from] hypothetical protein GOS_9604296 [marine metagenome] #=GS EBV71885.1/23-88 DE [subseq from] hypothetical protein GOS_6861117 [marine metagenome] #=GS 2004031701/3-80 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 8]' #=GS 2001327615/11-172 DE [subseq from] 'Predicted hydrolases of HD superfamily [Soil: Diversa Silage]' #=GS EBG38922.1/30-156 DE [subseq from] hypothetical protein GOS_9441345 [marine metagenome] #=GS EBB71224.1/22-156 DE [subseq from] hypothetical protein GOS_188642 [marine metagenome] #=GS 2004029449/11-170 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 8]' #=GS EDA36239.1/10-158 DE [subseq from] hypothetical protein GOS_2015339 [marine metagenome] #=GS EBM43814.1/23-138 DE [subseq from] hypothetical protein GOS_8410007 [marine metagenome] #=GS ECV28813.1/10-159 DE [subseq from] hypothetical protein GOS_2928062 [marine metagenome] #=GS EDA53413.1/17-162 DE [subseq from] hypothetical protein GOS_1983850 [marine metagenome] #=GS ECL79367.1/8-153 DE [subseq from] hypothetical protein GOS_5465663 [marine metagenome] #=GS ECU88233.1/9-158 DE [subseq from] hypothetical protein GOS_3003009 [marine metagenome] #=GS EDA69095.1/58-202 DE [subseq from] hypothetical protein GOS_1955342 [marine metagenome] #=GS EBF99851.1/16-168 DE [subseq from] hypothetical protein GOS_9506343 [marine metagenome] #=GS EBG46322.1/3-102 DE [subseq from] hypothetical protein GOS_9428984 [marine metagenome] #=GS ECL59140.1/10-83 DE [subseq from] hypothetical protein GOS_6296262 [marine metagenome] #=GS ECW26205.1/60-183 DE [subseq from] hypothetical protein GOS_2752272 [marine metagenome] #=GS 2001267733/28-90 DE [subseq from] '[Soil: Diversa Silage]' #=GS EDC62658.1/1-92 DE [subseq from] hypothetical protein GOS_1443032 [marine metagenome] #=GS ECE61431.1/4-66 DE [subseq from] hypothetical protein GOS_5989485 [marine metagenome] #=GS ECP58583.1/11-98 DE [subseq from] hypothetical protein GOS_5493368 [marine metagenome] #=GS ECB28755.1/2-86 DE [subseq from] hypothetical protein GOS_4969565 [marine metagenome] #=GS EDJ62400.1/3-81 DE [subseq from] hypothetical protein GOS_1662597 [marine metagenome] #=GS ECM79650.1/4-138 DE [subseq from] hypothetical protein GOS_4979861 [marine metagenome] #=GS 2004003203/1-64 DE [subseq from] 'Similar to unknown protein [Human Gut Community Subject 7]' #=GS 2004022490/4-146 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 7]' #=GS EDB07243.1/1-78 DE [subseq from] hypothetical protein GOS_1886784 [marine metagenome] #=GS EBB53579.1/32-71 DE [subseq from] hypothetical protein GOS_217028 [marine metagenome] #=GS 2004005245/10-78 DE [subseq from] 'Predicted hydrolases of HD superfamily [Human Gut Community Subject 7]' #=GS 2001363003/3-60 DE [subseq from] '[Soil: Diversa Silage]' #=GS EBS13631.1/25-185 DE [subseq from] hypothetical protein GOS_7485416 [marine metagenome] #=GS EBE84336.1/19-62 DE [subseq from] hypothetical protein GOS_9695509 [marine metagenome] #=GS ECQ61174.1/17-83 DE [subseq from] hypothetical protein GOS_4967931 [marine metagenome] #=GS EBF67931.1/17-83 DE [subseq from] hypothetical protein GOS_9558357 [marine metagenome] #=GS EBF86036.1/17-83 DE [subseq from] hypothetical protein GOS_9528874 [marine metagenome] #=GS ECT67365.1/17-83 DE [subseq from] hypothetical protein GOS_5024548 [marine metagenome] #=GS ECG63741.1/17-83 DE [subseq from] hypothetical protein GOS_4952234 [marine metagenome] #=GS EBF99275.1/17-83 DE [subseq from] hypothetical protein GOS_9507383 [marine metagenome] #=GS ECH49698.1/17-83 DE [subseq from] hypothetical protein GOS_5024214 [marine metagenome] #=GS EBF52119.1/17-83 DE [subseq from] hypothetical protein GOS_9584025 [marine metagenome] #=GS ECU29005.1/17-83 DE [subseq from] hypothetical protein GOS_4956281 [marine metagenome] #=GS ECM78864.1/17-83 DE [subseq from] hypothetical protein GOS_5014165 [marine metagenome] #=GS EBF75926.1/17-83 DE [subseq from] hypothetical protein GOS_9545162 [marine metagenome] #=GS EBF29277.1/60-141 DE [subseq from] hypothetical protein GOS_9621685 [marine metagenome] #=GS EBF54896.1/13-79 DE [subseq from] hypothetical protein GOS_9579599 [marine metagenome] #=GS EBF13434.1/17-83 DE [subseq from] hypothetical protein GOS_9647290 [marine metagenome] #=GS ECV91022.1/17-83 DE [subseq from] hypothetical protein GOS_2813628 [marine metagenome] #=GS ECW38121.1/17-83 DE [subseq from] hypothetical protein GOS_2731156 [marine metagenome] #=GS EBF81682.1/17-83 DE [subseq from] hypothetical protein GOS_9535831 [marine metagenome] #=GS ECW46692.1/17-83 DE [subseq from] hypothetical protein GOS_2716404 [marine metagenome] #=GS ECV96661.1/19-85 DE [subseq from] hypothetical protein GOS_2803890 [marine metagenome] #=GS EBF42087.1/17-83 DE [subseq from] hypothetical protein GOS_9600577 [marine metagenome] #=GS EBG00104.1/17-83 DE [subseq from] hypothetical protein GOS_9505941 [marine metagenome] #=GS ECW17844.1/17-83 DE [subseq from] hypothetical protein GOS_2766814 [marine metagenome] #=GS ECW35895.1/17-83 DE [subseq from] hypothetical protein GOS_2735196 [marine metagenome] #=GS EBF95209.1/17-83 DE [subseq from] hypothetical protein GOS_9513922 [marine metagenome] #=GS ECT05329.1/25-109 DE [subseq from] hypothetical protein GOS_7099731 [marine metagenome] #=GS EBG29123.1/16-158 DE [subseq from] hypothetical protein GOS_9457748 [marine metagenome] #=GS EBD46766.1/8-57 DE [subseq from] hypothetical protein GOS_9924938 [marine metagenome] #=GS EBF19736.1/17-77 DE [subseq from] hypothetical protein GOS_9637136 [marine metagenome] #=GS ECW30058.1/17-77 DE [subseq from] hypothetical protein GOS_2745619 [marine metagenome] #=GS ECR13355.1/5-61 DE [subseq from] hypothetical protein GOS_6391472 [marine metagenome] #=GS ECA92684.1/17-85 DE [subseq from] hypothetical protein GOS_6412230 [marine metagenome] #=GS ECV99153.1/3-56 DE [subseq from] hypothetical protein GOS_2799604 [marine metagenome] #=GS EDB98002.1/60-163 DE [subseq from] hypothetical protein GOS_1558182 [marine metagenome] #=GS 2001295510/48-115 DE [subseq from] 'Predicted hydrolases of HD superfamily [Soil: Diversa Silage]' #=GS EBV61749.1/39-135 DE [subseq from] hypothetical protein GOS_6877301 [marine metagenome] #=GS EBX47944.1/59-121 DE [subseq from] hypothetical protein GOS_6580837 [marine metagenome] #=GS ECU26793.1/49-112 DE [subseq from] hypothetical protein GOS_5045647 [marine metagenome] #=GS ECV23895.1/50-135 DE [subseq from] hypothetical protein GOS_2937746 [marine metagenome] #=GS ECV96166.1/1-52 DE [subseq from] hypothetical protein GOS_2804737 [marine metagenome] #=GS EBJ47202.1/38-111 DE [subseq from] hypothetical protein GOS_8892738 [marine metagenome] #=GS ECV79119.1/38-112 DE [subseq from] hypothetical protein GOS_2834752 [marine metagenome] #=GS ECB43686.1/63-136 DE [subseq from] hypothetical protein GOS_4359429 [marine metagenome] #=GS EBC06120.1/37-109 DE [subseq from] hypothetical protein GOS_130611 [marine metagenome] #=GS EBD96526.1/37-109 DE [subseq from] hypothetical protein GOS_9843295 [marine metagenome] #=GS EBU03607.1/49-105 DE [subseq from] hypothetical protein GOS_7176564 [marine metagenome] #=GS EDI71748.1/56-120 DE [subseq from] hypothetical protein GOS_385901 [marine metagenome] #=GS EDC49985.1/38-109 DE [subseq from] hypothetical protein GOS_1465450 [marine metagenome] #=GS EDD12569.1/37-110 DE [subseq from] hypothetical protein GOS_1354961 [marine metagenome] #=GS EDB78255.1/37-110 DE [subseq from] hypothetical protein GOS_1593685 [marine metagenome] #=GS EBC90351.1/38-111 DE [subseq from] hypothetical protein GOS_10016860 [marine metagenome] #=GS EBD84596.1/37-105 DE [subseq from] hypothetical protein GOS_9862878 [marine metagenome] #=GS EBH05856.1/37-110 DE [subseq from] hypothetical protein GOS_9327759 [marine metagenome] #=GS ECH80805.1/45-117 DE [subseq from] hypothetical protein GOS_3797637 [marine metagenome] #=GS EBE06371.1/38-111 DE [subseq from] hypothetical protein GOS_9827134 [marine metagenome] #=GS ECS43232.1/38-112 DE [subseq from] hypothetical protein GOS_4730813 [marine metagenome] #=GS ECS43230.1/38-112 DE [subseq from] hypothetical protein GOS_4730811 [marine metagenome] #=GS ECY65287.1/6-77 DE [subseq from] hypothetical protein GOS_2322139 [marine metagenome] #=GS ECA13796.1/55-115 DE [subseq from] hypothetical protein GOS_6061569 [marine metagenome] #=GS ECA97378.1/37-108 DE [subseq from] hypothetical protein GOS_6226141 [marine metagenome] #=GS EBZ27555.1/37-100 DE [subseq from] hypothetical protein GOS_6005257 [marine metagenome] 2004016891/30-191 -DKEKFIGR...QTYL.SD.G..K-..RK...ENDAEHAWHLA.LM.T....LLLS....EYAN......EKI...DTLK...TMTMV...LFHDVVEIDAGDTYAYD.....E.EGKKT...QAQREQKAAERL.YGL......LPED..........QG.AKLKAIWE........EFEAKNTPESRF..........AHTMDNLQPVILNAATDGKAWKEH.QVRLSQFMGR-QEDTPKGSETLW 2004047245/16-178 IDKEKFIIR...QTYL.SD.A..R-..KK...ENDAEHAWHMA.IM.T....VMLS....EYAN......SEI...DVLK...TMTML...LIHDIVEIDAGDTYAYD.....E.KAKKT...QAEREMKAAKRI.FGL......LPED..........QG.EKMMNLWL........EFESGETAEAKF..........AHTMDNIQPAMLNDATDGKAWVEH.IVHLHSILNR-NKNTADGSKKLW ECD43324.1/17-179 -EGLKQIFR...QTVL.PA.D..G-..RA...ENDAEHSWHLS.LM.A....ILLI....EHAK.....vDDL...DLLR...VLKML...LIHDIVEIDAGDTFAYD.....E.AGNRD...KEERERAAAERL.FNL......LPDK..........QA.VELRALWD........EFEARETGEARY..........AAALDRFQPILLNCHTEGAAWRRH.GVKRAQVIAR-NEHIKEGIPALW ECO13048.1/60-221 -DQLKTVLR...QSML.AD.G..S-..RQ...ENSAEHSWHLA.MT.A....MTLA....PLAD......EPI...DVER...AIKIL...LVHDIVEIDAGDVFIYD.....D.AQRAA...AEAAEQEAADRI.FGL......LPAE..........QG.AEFRALWD........EYEDRSTPEGRF..........AYACDRLQPLLLNVAIGGGSWRHH.GVTADRVKAI-NGAIDDGLSRVW 2004014582/14-176 IDKEKQMKR...KTLQ.SN.G..K-..DF...EDDAQHAWHMA.IM.T....LLLS....EYAN......EEI...DVLK...TISML...LIHDLVEIDAGDTYAYD.....D.LGLKT...QSERENLAANRI.FNL......LPDD..........QA.KKVFNLWN........EFEERKTPEAKF..........ARGMDNFQPVMLNAATDGRMWAEN.GVHLEKILKR-NEKTHEGSEVLW 2004215145/37-200 ADKLKHVLR...QTIL.MD.R..S-..RR...ENSSEHSWHIA.LL.V....FVLA....EYSH.....dPDL...DMLH...VMKML...VIHDLVEIDAGDTYCYD.....D.KGRED...QAQREAIAADRI.FGL......LPGD..........QA.PEFRALWD........EFEKKETAESRF..........ANALDRVQPFLHNYFTDGQTWQEN.EINSRQVHER-MRPVKDGAPDLW EDF86621.1/62-223 -DQLKTVLR...QSML.AD.S..S-..RQ...ENSAEHSWHLA.MT.A....MTLA....PLAD......EPI...DVER...AIKIL...LVHDIVEIDAGDVFIYD.....D.AQRAA...AEAAEQEAADRI.FGL......LPAE..........QG.AEFRALWD........EYEDRSTPEGRF..........AYACDRLQPLLLNVAIGGGSWRHH.GVTADRVKAI-NGAIDDGLSRVW ECZ92015.1/29-192 -DQLKAVKR...QITL.PC.D..NY..RQ...ENSAEHSWHVA.LM.A....NMLS....EYAA......KPI...DVTR...VIRMI...LIHDIVEIDAGDMFAFN.....HqTDHDA...QAEKELAAAKRI.FGL......LPSP..........LD.NEMLELWL........EFEAAETADAEF..........AKAMDRVLPVFQNMKDNGGSWKRH.GIAREKIEKR-NAHLKSCAPALW ECI40634.1/39-199 -DRLKQVER...RTWL.LD.R..T-..RR...ENDAEHSWHLA.ML.A....LVFA....DQAG......PEV...AIDR...VVRML...LIHDIVEIDAGDSFLFD.....D.EAAAD...QQARERRAADRI.FGL......LPPD..........QG.LALRALWD........EFEARVTPDARF..........AKALDRFQPLLHDHLTDGGSWRDH.AVTAAQVADR-LSVIGDGAPRL- 2004037699/21-181 -DEEKFIER...KTLV.SS.G..E-..RF...ENDAEHAWHMA.LM.C....VLLS....EYAN......EPI...DVLK...TVKMI...LIHDIVEIESGDTYAYD.....E.AGKAT...QHERELKAADKL.YNM......LPQD..........QA.KEYFNLWL........EFEEQKTAEAKF..........ARSMDNVQPNMLNNATDGEMWKRN.KIKLSQVLKR-NELTKYGSETL- EDJ59727.1/35-197 IDKLKDVLR...ATHN.LH.N..G-..KP...ENSAEHSWHLA.MI.A....SVLA....EYAN......EPV...SIDR...VVRML...LIHDLVEIDAGDHPLHG.....D.HDPQA...QAEAEQAGADRL.FGL......LPSD..........QQ.DTWRALWD........EFESAESPDARF..........AKACDRFQPLICNMMNRGGSWPEY.QVSRSQVEAR-VGKIQTGSQTLW EDJ37625.1/19-182 IDRLKSVVR...QNRL.AD.G..S-..RR...ENSAEHSWHLA.MF.A....VVLA....DHA-......EGV...DLWR...VVRML...LIHDIVEIDAGDHGYHE.....DgHDWDA...IAAKERAAADRL.FGM......LPPP..........MD.AELRALWD........EFEAAETADARF..........AKALDRLQPVLLNVLAGGGTWDDH.AVDEARVVSRTGRTIEAGSPRLW EBO59136.1/16-170 -DTFKFIKR...KIYL.ND.K..N-..RL...ENDAEHSWHVA.MM.V....WLFS....GYLG......KKI...NSER...AIKMA...LMHDLVEIYAGDTFAYD.....S.SGRIG...KADREKKAAKKL.FSK......LPQE..........SK.KEFEEIWK........EVEDKKTPEAGL..........VQAMDKLQPILQNILVRGKNHQKF.KVTEQMIRAEKSRHF-------- ECM81083.1/21-164 AEQLKLELR...HSWL.SN.G..--..RQ...ESVAEHSWRLA.LM.V....VSLA....PYLE......HPV...NVEK...ALKMA...IIHDIAEAEAGDIAVFEc..qtA.EAKRA...KHQAEEQAIDNI.RAR......LPAP..........LG.EELYQLWH........EYEARETLEAKF..........VTALDKIEVFIQHNEADLDTWLHL.E---------------------- 2001361224/17-144 CDRLKDIVR...QTLN.AH.S..G-..RP...ENDAEHSWALC.LF.V....MTLA....EHSN......TPI...DVLR...VMKML...LIHDIVEIDAGDTFAYD.....T.RRQAD...QREREAAAATRI.FGL......LPED..........QA.AEFRALWD........EFEDRKTSNAQF..........AHAIDRCQAML-------------.----------------------- EDD28306.1/6-168 ADRLKSVVR...GNRI.AD.G..S-..RR...ENTAEHSWHIA.LF.A....LVLA....PHAV......EQV...DVLR...VVSML...QIHDLVEIDSGDTLLYD.....A.AGTAM...QAAREEVAARRL.FGL......LPAG..........QA.SEFLALWQ........EFEAAVTADARF..........AKSVDRLQPILLNHAAGGGTWTDY.DVDEARERAL-TGRIAEGSPALW EBF34560.1/38-188 AERLKHVLR...TAWT.RT.G..--..RQ...ESTADHSWRIC.LL.I....MMLE....PDL-......EGV...DFTR...VLKMA...IVHDLGEALGGDVPAPL.....A.STAPD...KEAREREDLERL.TAI......LPAD..........LR.AHVLELWD........EYCAAETAEARL..........VKGLDKLETIIQHNQGENPPWLDY.--DFNLQYGVRYTE--------- ECN21825.1/26-178 -ESLKSTLR...SGHT.SS.G..--..RP...ESVADHTWRLC.LL.V....LVLA....PEF-......PEV...DAHR...LMKIC...LIHDLGEALQGDIPAPL.....Q.DPNVD...KSQSEREDLLEL.LSP......LPEL..........QR.GEILELWE........EYEQAATPEAKL..........AKAFDKLETLLQH--TQGENPPDF.DYAFNLDYGRRYTELNV------ EBV84904.1/24-142 IDRLKSVDR...QTLI.TD.R..S-..RR...ENTAEHSWHLA.MF.A....FVLA....EHAN......DDI...DLLH...VLQLC...LVHDIVEIDAGDTFAYD.....T.TAYSD...KDEREQRAADRL.FGL......LPAD..........QH.ARLRALWE........EYEAMETPESRF..........AT----------------------.----------------------- ECV10182.1/39-193 AERLKDVLR...SGHT.SS.G..--..RA...ESTAEHSWRLC.LM.A....LVFA....DAL-......PGI...DTLK...LLKLC...VVHDLGEALHGDIPAID.....Q.ATHPD...KSAQERDDLLTL.TAP......LDPA..........QR.DEIVALWD........EYEAAATPEARA..........AKALDKLETILQH--NQGSNPPDF.DYAFNLGYGRRYTDAAPL----- 2001514866/15-154 ADKLKSVTR...GTLL.CD.A..S-..RA...ENSAEHSWHLT.LY.A....LVLA....DQAG......EGV...DITR...VIKML...ILHDLVEIDAGDNPIFG.....S.YDAAD...MEAQEQLAADRI.FDL......LPND..........LR.DDLRATWE........EFEANKTPTARF..........AKSLDQVPAAHAEHCRGRGSWSN-.----------------------- EDD24427.1/18-180 ADKLRRVKR...QNLI.LD.G..S-..RE...ENAAEHSWHLA.LY.A....LAFA....PFAP......ADV...SISR...VVQML...LLHDLVEIDAGDHPIGD.....D.IDWTA...VADAEAAAATRL.FAL......LPAD..........QS.VFMHGLWR........EFDAAETADARW..........AKRIDHCQPIFQTLCNADVPDFHV.EIVRSNLFGGRAAALKDHFPEV- EDE24202.1/22-159 --QLKKIPR...SGWK.KK.L.gIK..NP...ESVADHAYSVA.AI.A....MILS....DAKR......--L...DTQK...ILKMA...LLHDLAESIVGDLTPED.....-.ATKQQ...KANLENTAMKKI.LST......INNT..........QS.KQYWKIWI........EYQKQSSKEAKL..........LHDVDKLEMALQAIIYKKSKHNVR.----------------------- EBG37363.1/97-247 --NLKKISR...QGWI.EK.L.dMK..NP...ESVADHTFMMA.IV.G....MLIS....DSEK......--Y...DFKK...ILKMI...LLHDLAESKIGDFTPNQ.....-.ITKEK...KLELENQAFSEL.LNN......LPSN..........LH.ENYHEIWQ........EFIECESDESKL..........VHEIDKFEMAIQAKKYEQSGFS--.KEKLQQFYDSAEQEI-------- 2000450180/16-170 AERLKDVLR...TAYT.RT.G..--..KQ...ESTAEHTWRLC.LF.I....LSFA....DQL-......PDL...DLLK...VIKMA...LLHDLGEAIHGDTPAID.....-.QQNFD...KLEQERADLVTL.MQS......LPRE..........LQ.TEFLELWD........EYNQAQTPEAQA..........VKAFDKLETILQH--NQGANPPEF.DYAFNLAYGQRYTQTNPLF---- EBY78793.1/24-174 -EPLKDTLR...SGKT.GQ.G..--..RS...ESTAEHTWRLC.MF.V....LVFA....DHMD......-GV...DLLK...LMKMC...LVHDLGETYAGDVPAIF.....Q.NADDD...RKQIEQRDMAKL.ALI......LDDQ..........TG.DEVLALWH........EYEVGETVEARL..........AKGFDKIETMLQH--TQGKNAADF.DYAFNLDYGLAQTDA-------- EDE56184.1/23-167 --NLKTKPR...RGWQ.KKiG..IK..KP...ESVADHAYAVA.TI.A....MILS....DSKK......--L...NSEK...ILKMA...LLHDLAESITGDLTPD-.....-.--DGP...KKKKENAAMKKI.ISS......LRPT..........LR.KQYWSLWI........QYQNNTTKEARL..........LHDIDKLEMALQAKKYRTNGHSRK.--KLEQFFDSAL----------- EDA59223.1/10-145 -AELKKLPR...SGWKiKV.G..LE..NS...ESVAEHSYMMS.VM.S....MVLS....DMKS......--L...NSEK...VLKMA...ILHDWAESKIGDFMP-E.....Q.IGYDK...KSELENYAMSEI.LES......LPQK..........IQ.NDYQNIWD........EFLSRETPESKL..........VYELDKLEMALQAKIYEKDVD---.----------------------- EDE46798.1/23-165 --NLKTKPR...RGWQ.KK.L.gIK..NP...ESVADHAYCVA.AI.A....MVLT....DSKK......--L...NSEK...ILKMA...ILHDLAESITGDLTPED.....-.---GP...KQKKEDAAMKKI.LST......LNPP..........IR.KQYWLLWN........QYKKNTTREAKL..........LHNVDKLEMAIQAKQYQKMGYSRK.--KLEQFFDS------------- EBG18030.1/10-145 -AELKKLPR...SGWKiKV.G..LE..NS...ESVAEHSYMMS.VM.S....MVLS....DMKS......--L...DSEK...VLKMT...ILHDWAESKIGDFMP-E.....Q.IGYDK...KSELENYAMSEI.LES......LPQK..........IQ.DDYQNIWD........EFLSRETPESKL..........VYELDKLEMALQAKIYEKDVD---.----------------------- EBB21000.1/18-153 -AELKKLPR...SGWKiKV.G..LD..NS...ESVAEHSYMMS.VM.S....MVLS....DMKS......--L...DSEK...VLKMA...ILHDWAESKIGDFM-PD.....Q.IGYDK...KSELENYAMSEI.LES......LPEK..........IQ.NDYQNLWN........EFLLRDTQESKL..........VHELDKLEMALQAKIYEKEAD---.----------------------- EBH79950.1/18-151 -AELKKLPR...SGWKiKV.G..LE..NS...ESVAEHSYMMS.VM.S....MVLS....DMKS......--L...DSEK...VLKMT...ILHDWAESKIGDFM-PD.....Q.IGYDK...KSELENYAMSDI.LES......LPEK..........IQ.NDYQNLWN........EFLLRETQESKL..........VHELDKLEMALQAKIYEKE-----.----------------------- 2004171367/198-377 CGQLRFQIR...--WS.QT.P..RL..PK...TSVLGHMLLVA.IF.C....YLFA....REVN......--A...CSKR...LYNNFfsaLFHDLPEAMTRDILSPIkrsveG.MPEAI...SKIEEELAEKEI.SPL......LEEG..........WF.EEIKYFTR.......nEYESKIKIKGRVkhvttekineKYNSDGYAPIDGEFIKIADDLSAYlEAYTANDLGLNSKHLQDGRRKI- EBX51854.1/3-140 --HLKQVFR...KGWL.ER.GlpPA..RC...ESVAEHSFGNA.ML.C....LLLA....QQQ-......PGL...NVEK...ILRMA...LIHDLGEVYVGDLTPTD.....A.VDPQE...KYAMEKQAVLKI.LSG......LPAG..........--.KTLLENWE........EYEAQVTPEAQF..........VKQVDRLEFALQAAQYEQADLIT-.----------------------- EDH30046.1/1-140 ---LKQVFR...KGWL.ER.GlpPA..RC...ESVAEHSFGNA.ML.C....LLLA....QQQ-......PGL...NVEK...ILRMA...LIHDLGEVYVGDLTPTD.....A.VDPQE...KYAMEKQAVLKI.LSG......LPAG..........--.KTLLENWE........EYEAQVTPEAQF..........VKQVDRLEFALQAAQYEQADLITA.-AD-------------------- EBX19362.1/56-193 --HLKQVFR...KGWL.ER.GlpPA..RC...ESVAEHSFGNA.ML.C....LLLA....QQQ-......PGL...NVEK...ILRMA...LIHDLGEVYVGDLTPTD.....A.VDPQE...KYAMEKQAVLKI.LSG......LPAG..........--.KTLLENWE........EYEAQVTPEAQF..........VKQVDRLEFALQAAQYEQADLIT-.----------------------- EBP95157.1/1-137 ---LKQVFR...KGWL.ER.GlpPA..RC...ESVAEHSFGNA.ML.C....LLLA....QQQ-......PGL...NVEK...ILRMA...LIHDLGEVYVGDLTPTD.....A.VDPQE...KYAMEKQAVLKI.LSG......LPAG..........--.KTLLENWE........EYEAQVTPEAQF..........VKQVDRLEFALQAAQYEQADLIT-.----------------------- ECD88629.1/5-143 ---LKQLPR...TGWV.RS.N..VS..NP...ESVAAHSWGMA.IL.A....LRLA....PND-......--I...DLTK...VLSMC...LVHDLPEVIVGDLTPHD.....-.-DITS...KAEQEHDAMRRL.AP-......----..........--.-EWLALFE........EYEAGESKEAKF..........VKQIDKLDMALQAILYQNEQGLDLsEFLVSAKAKISD----------- ECP10116.1/11-138 --ELKALPR...AGWI.RK.G..IK..HP...ESVAAHSWGLS.ML.C....LEYA....PRMH......PKL...NLEK...VLKLA...LTHDVPEVLAGDITPHD.....G.ISKAQ...KQYLELNSAKSI.LNS......----..........--.-SMFKLWL........EYEKNESPEAKF..........VHAMDKIDMALQAMLYQSQ-----.----------------------- ECY71067.1/11-145 --GLKELPR...SGWKiKV.G..LN..DT...ESVAEHSYMMS.VM.A....MVLS....DLKS......--L...DSEK...VIKMS...ILHDWAESKIGDFM-PD.....E.IGYDK...KSELENYAMIEI.LES......LPQS..........LQ.SNYQNIWN........EFLVRETQEARL..........VHELDKLEMALQAKIYEKDVD---.----------------------- EBK30484.1/17-153 ---LKQLPR...TGWV.RS.N..VS..NP...ESVAAHSWGMA.IL.A....LRLA....PND-......--I...DLTK...VLSMC...LVHDLPEVIVGDLTPHD.....-.-DTTN...KAEQEHDAMKQL.AP-......----..........--.-DWLALFE........EYEAGESKEARF..........VKQIDKLDMGLQAILYQNEQGLDLsEFIVSAKAKI------------- EDC51554.1/27-153 --KLKSVMR...EGWV.RA.G..VN..NP...ESVAAHAWGMA.LL.A....MHLC....PEN-......--I...DKMR...VIEMC...LVHDLPEIIVGDLTPHD.....-.-DTSN...KHEDEVRAMKEI.APQ......----..........--.--WLEYFE........EYEENETEEAKF..........VKYLDKLDMALMARLYENEQGLNL.----------------------- ECN79300.1/17-154 ---LKQLPR...TGWV.RS.N..VE..NR...ESVAAHSWGMA.IL.A....LRLA....PND-......--I...DLTK...VLSMC...LVHDLPEVIVGDLTPHD.....-.-DTNN...KAELEHNAMKQL.AP-......----..........--.-RWLALFE........EYEAGESKEARF..........VKQIDKLDMGLQAIIYQNEQGLDLsEFLVSAKAKIS------------ EDH82343.1/41-179 --HLKQVFR...KGWL.ER.G..IHpaRC...ESVAEHSFGNA.ML.C....LLLA....QGR-......EDL...NLER...VLRLA...LIHDLGEVYVGDLTPKD.....A.VDRDA...KIAMERDAVNKI.LGP......LPNA..........--.AALIADWE........EYEAQASVEARF..........VKDIDRLEFALQAAHYQTAELMDS.----------------------- EBC02023.1/24-160 --ELKQLSR...TGWV.RS.G..VN..NP...ESVAAHSWGMA.VL.A....LRLA....PKE-......--L...DLEK...ILSLC...LVHDLPEVRVGDLTPHD.....-.-DTSN...KAELEHKAMSEI.APQ......----..........--.--WLSLFE........EYEAGETAEAKF..........VKQIDKLDMGLQAILYQTKQNITL.DEFIESAKSK------------- EBC21879.1/12-148 --KLKDIPR...TGWV.RA.S..VS..EP...ESVAAHSWGMA.IL.A....LRLC....PVH-......--L...DLSK...VLQLC...LVHDVAEIVVGDLTPHD.....S.IKGKE...KHELEREGMLKI.APQ......----..........--.--WIELFD........EYEQGSTEEAQF..........VKTMDKLDMGLQAIHYQRQGLNLS.EFIKSARS--------------- 2000101320/1-112 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...---MV...LIHDIVEIDAGDTFIYD.....N.AKNHT...NTDEELNAAKRI.FGI......LPAS..........QA.EEFINIWK........EFEDGITDEAKF..........AKSMDRFEPLLQNTSNKGGTWVEF.NVPYQKVYEK-KSAIKNGSSTIW EBZ64328.1/3-136 ---------...----.--.-..--..--...-----------.LL.A....LSLN....KFAD......AQV...DMTK...VISML...LVHDIGEIDTGDTMFFV.....E.GGWDN...RKADEMEAVKRI.FGF......LPEE..........TA.TTFLALWE........EFEFGTTAESKF..........ANALDRAMPVLLNLENEGQSWRDN.NISYDRVVSKIKPPIETGFPALW EDC90383.1/41-180 --SLKQLPR...TGWV.RS.N..VE..NP...ESVAAHSWGMA.IL.A....LRLA....PKE-......--L...DLKK...VLTMC...LVHDLPEIIVGDLTPHD.....-.-DTTN...KAELEHDAMKQL.A--......----..........--.PEWLALFE........EYDVGKSKEAKF..........VKQIDKLDMGLQAILYQNEQGLDLsEFLVSAKAKISD----------- EBN84967.1/24-161 --ELKQLPR...TGWV.RS.G..VN..TP...ESVAAHSWGMA.VL.A....LKLA....PKE-......--L...DLEK...ILSLC...LVHDLPEVRVGDLTPHD.....-.-DTSN...KAELEHKAMSEI.APQ......----..........--.--WISLFE........EYEAGETAEAKF..........VKQIDKLDMGLQAILYQTKQDITL.----DEFIESAKSKI-------- ECD52160.1/1-135 ---------...----.--.-..--..--...----------A.LF.A....LVLG....SDAP......ADV...NVDR...VIKML...LLHDIVEIDAGDAPIFG.....D.HDATE...MAAKEVAAATRL.FGL......LPPD..........QA.QSFRALWD........EFEAAQSPDARF..........AKSLDRFQPPNQNLASGGGSWVEY.DTDYARFEARVGNKIKRGAPLLW EDJ34487.1/17-173 --ALKDHLR...NSWT.RG.G..--..RR...ESVAEHSWRVA.LT.A....LALR....EADPt...tkAET...DLGR...VLALC...LVHDLGEALGGDVPAAS.....M.PDRAA...KTARERADLAAL.LAP......APDG..........AR.AAIAALWE........EHESGDTPEARI..........SRAADKLETVMQH--AEGANPPGF.DYGFNLDYGRAQTDAHPV----- EDC18192.1/17-145 ---LKQLPR...TGWV.RS.N..VE..HP...ESVAAHSWGMA.IL.A....LRLT....PKE-......--L...DLIK...VLSMC...LVHDLPEIIVGDLTPHD.....N.LN--N...KAEMERNAMKQL.A--......----..........--.PEWLELFE........EYEVGESKEAKF..........VKQIDKLDMGLQAIFYQNEQGLDL.----AEF---------------- EBD28582.1/13-137 ---LKDILR...TGWV.RA.G..VD..SP...ESVAAHSWGMS.VL.A....MHLC....PEN-......--L...NRMR...VIEMC...LVHDLPEVEVGDLTPHD.....-.-DTST...KSEDEHRAMTRL.APQ......----..........--.--WLGLFE........EYEAQETEEAKF..........VKYLDKLDMALMARIYEDKQGLD-.----------------------- EBW84243.1/13-146 ---LKEVDR...AGWK.RS.G..LT..DV...ESVAGHSWGVA.FL.A....MQIC....PPE-......--L...DRLK...VIEMA...VCHDVAEVRVGDITPHD.....G.ISAEE...KVRIETEAMLSL.SKG......FPRG..........--.DHMLELYR........EYEVGETAEARF..........LKLCDKLDMAFQSYVYQSRTESNL.----------------------- 2001443116/1-142 ---LKDVFR...SGFT.GE.G..--..RP...ESTAAHTWRLC.LW.V....LVFE....DQLD......-GL...DLAR...LLKLA...VLHDLGEAVSGDIPA--.....T.AQQTD...KGAAERADFVSL.LDG......LRGD..........QA.ADFLQLWD........EYENAASPEARV..........IKGLDKLETILQH--TQGKNPDDF.DYGFNLDYGQ------------- EBN67446.1/39-180 ---LKEVLR...SGWV.RN.G..VS..NP...ESVAAHSWGMA.IL.A....LKLT....PKD-......--L...DLVK...VISLC...LVHDIPEVRVGDLTPHD.....D.--CSN...KAQDESRAMKEL.A--......----..........--.PEWFALFE........EYELGESEEAKF..........VKQLDKLDMGLQAMIYESKQGLDLsEFKQSALSKITNSEL-------- ECF22336.1/41-169 ---LKEIQR...TGWV.RA.G..VP..RS...ESVAAHSWGMA.ML.A....MKFC....PEQ-......--L...NRER...VLEMC...LIHDLAEIIVGDLTPKD.....-.-DTST...KAEDEEAAMHVL.A--......----..........--.PEWLSIFQ........EYERGQTPESKF..........VKKMDKLDMKYTAENYQEIY----.GLDLQEF---------------- ECG16269.1/40-180 ---LKDVVR...TGWV.RN.N..VS..NP...ESVAAHSWGMA.IL.A....LKLT....PKN-......--L...DLNK...VLSLC...LVHDIPEVRVGDLTPHD.....-.-DCST...KSEDELNAMKEL.SP-......----..........--.-EWLHLFE........EYELGETEEAKF..........VKQLDKLDMGIQAMIYENRQGLDLsEFKESALSKITNLE--------- EBV34816.1/13-138 ---LKDVAR...QGWV.NA.G..VS..NP...ESVAAHSWGMA.VL.A....LKLC....PDN-......--L...NLEH...VLKLC...LVHDLPEVIVGDLTPHD.....-.-DRTT...KAEDERKAMEQL.AP-......----..........--.-EWLGLFD........EYEAQSTPEAVF..........VRSLDKLDMALQARVYMERTDLDL.----------------------- ECE97094.1/8-134 -DRIKHLNR...AGWV.LA.G..HD..AP...ESVAAHSWGMA.VR.C....LQHC....PED-......--L...DLAT...VLSMA...LVHDLAEAVVGDITPHD.....G.VDKAE...KHARERAAMASI.APQ......----..........--.--WLDLWD........LYEAGDSPEAVF..........VKRMDSLDMAAQAVAYEAQGL---.----------------------- 2001410408/1-159 ---------...----.--.-..--..--...------MLTVA.IF.G....YFYS....LKIN......--A...CDKR...IQNNFfvaLFHDLPEALTRDIISPVkysvdE.LADII...AEYEVSQIEDKI.MPY......VPMN..........LK.KEFSYILGldknnikdEFENKIIQNETIttv...admsQYNLDKYNPIDGKALKQCDKLSAFiEASLSISHGIKSKELISGKKQ-- EDB06617.1/11-145 ---LKDVLR...QGWV.NA.G..VE..SP...ESVAAHSWGMA.VL.A....LKLC....PDH-......--L...NLEH...VLKLC...LVHDLPEVVVGDLTPQD.....D.V--ST...KSADERAAMHQL.AP-......----..........--.-EWVPLFD........EYEQQTTPEAVF..........VKSLDKLDMALQAKVYMTRS----.DLDLSQFIESARK---------- EBT94870.1/11-141 ---LKDVLR...QGWV.NA.G..VE..SP...ESVAAHSWGMA.VL.A....LKLC....PDD-......--L...DLLH...VLKLC...LVHDLPEVVVGDLTPSD.....-.-DRST...KAADERTAMEKL.AP-......----..........--.-EWVALFD........EYEQQSTPEAVF..........VRSLDKLDMALQAKVYMERTDLDL.----HQFIE-------------- EBV45475.1/11-141 ---LKDVLR...QGWV.NA.G..VE..AP...ESVAAHSWGMA.VL.A....LKLC....PED-......--L...SLEH...VLKLC...LVHDLPEVIVGDLTPAD.....-.-DRST...KVADERAAMQEL.A--......----..........--.PEWVALFD........EYEQQSTPEAVF..........VRSLDKLDMALQAKVYMERTNLDL.HQFIE------------------ 2001515892/11-162 -DALKRVNR...RSYV.TE.T..T-..RL...ENSAEHSWHLA.MA.C....WSIA....ELFE......LDV...NHEK...LLKMA...LVHDLGEIDAGDTFLYA.....D.-TRRD...AHFEEREGIARL.QRE......RGNG..........-I.ADLSEIWE........EQETGNSKEADL..........LRVVDRLLPFLLNLNTEGKTWIEL.GVTRSQVAGA-HGFI-------- EBU44121.1/11-155 ---LKHVDR...AGWR.RA.R..AA..PV...ESVAAHSWGMA.LL.A....LRLC....PPE-......--L...DRAE...VLALC...ALHDLAEAIVGDITPHD.....G.VPPAE...KHRREDAAAAEL.LAD......A---..........--.PDLLRLFR........DYAERRTPAARF..........VRQLDKLDMALQAEIYAADGADTA.EFVESARRGITDPS--------- EDJ27905.1/42-192 ---LKDVPR...EGWR.LR.G..VG..EGgsvESVAAHAWGTA.LL.C....MLFA....DDAG......--V...DREV...ALEMA...LVHDVAEVETGDVAALLdasarR.MTEEE...KARREAEAMDRL.AGL......APGV..........-A.ERLRSRWQ........AYEAREGDAARF..........VRDMNLIDMVVQAWWYERVGRAAG.-GELDEFF--------------- ECJ75617.1/2-149 -------NR...RTYI.NG.G..E-..RV...ENSAEHSWHLA.MA.C....WAFA....ELLQ......GNY...DVPK...LIKLA...LIHDLGEIEAGDTFLYS.....-.DNRSN...AHVEERKGVKKI.ASH......-PGN..........SI.EDIVDLWD........EQEGGASKEARL..........LRVIDRLLPFLHNINSEGRAWRDN.NIHKNQVLKM-HKFVEN------ 2001429315/33-186 -DALKRVNR...RSYV.TQ.T..T-..RK...ENSAEHSWHLA.MA.C....WSIA....ELFA......LDV...NHEK...LLKMA...LVHDLGEIDAGDTFLYA.....-.DTRTD...AHVEERAGIARL.QRE......RGNG..........-I.SDLSKVWE........AQETGSSKESQL..........LRVVDRLLPFLLNLNTNGKTWIEL.GVTRSQVAGA-HAFIKD------ EBE97563.1/3-125 ---------...----.--.-..-E..NP...ESVAAHSWGMA.IL.A....LRLA....PND-......--I...DLTK...VLSMC...LVHDLPEVIVGDLTPHD.....-.-DTTN...KAELEHDAMKQL.AP-......----..........--.-DWLALFE........EYEAGESKEARF..........VKQIDKLDMGLQAILYQNEQGLDLsEFIVSAKAKI------------- ECE60760.1/17-119 ---LKTVPR...QGWK.EK.L.eID..HP...ESVADHSYTVS.IM.S....MVLS....DLEG......--L...NTEK...IIKMA...LLHDLAESVIGDIIPNT.....-.ITNDE...KILKENQAMKQI.LKN......LPNK..........II.GSYLEIWN........DY----------..........------------------------.----------------------- ECK57861.1/70-188 --RLKNIQR...AGWV.RA.G..IQ..NP...ESVAAHSWGMS.ML.A....LKLT....PPT-......--L...DLVR...VLSLC...IVHDVPEVRVGDLTPHD.....-.-DTTN...KARDEHEAMTEL.A--......----..........--.PEWITLFE........EYEHGQSPEAQF..........VKQLDKLDMALQAENY--------.----------------------- 2001496394/36-193 -DALKRVNR...RSYV.TG.T..T-..RL...ENSAEHSWHLA.MA.C....WSIA....DLFE......LDV...NHEK...LLKMA...LIHDLGEIDAGDTFLYA.....-.DTRVD...AHVEERAGIVRL.QNE......RGNG..........-I.ADLSEIWE........EQETGDSKETQL..........LRVVDRLLPFLLNINTNGKTWIDA.NVTRSQVAGA-HGFIKDSFPS-- EDC09957.1/1-125 ---------...-GWV.NA.G..VE..SP...ESVAAHSWGMA.IF.A....LKLC....PPE-......--L...NLQR...VLTLC...LVHDLPEVVVGDLTPHD.....D.CS--T...KAKDERAAMGQL.---......----..........-A.PEWVPLLD........EYESQSTPEAVF..........VRSLDKLDMALQAEIYMGRS----.ELDLSQFIES------------- EBG15065.1/41-191 --ELKQEIR...YGES.RT.D..AT..NP...ESVAEHVFGMH.VLfE....YFWP....LEDP.....gKKW...DQAK...MRQMI...TFHDVDEIITGDKIGYL.....-.-KTAA...DKAAEAHAHQQV.MEE......IPAT..........LK.NSIATVLS........EYEERETVEAKF..........IKAIDKIEPVFHVFNPAGKELLHRmRTTREQHDSI------------- ECH52038.1/14-166 -GVLKRVSR...SGWW.LI.N..IN..EP...ENVAEHSSRAA.MI.G....YFLA....KMEK......--V...DTNK...VVLMC...LFNDVHEARLNDLHKVG.....-.QRYID...FGKAESKAHQEQ.LSG......LDGS..........-G.DELLLLLT........EFQERKTPEAEV..........ARDADLLENAFQAREYIKAGYTDA.QDWIDNIWKVIKTDSG------- ECL91012.1/17-157 -GILQKTPR...SGFY.FL.G..S-..GS...QSVAEHLNRVT.YI.G....FVLS....QMN-......EEA...DTAK...VLEMC...MFHDFAEARVSDLNY--.....-.VHQKY...TERKEGEAVNDL.VAT......LPFG..........--.DKIKSIID........EYEDRQSIEAKL..........TKDADNLELLLALKEQADIGNERA.NTWIVPL---------------- EBU10991.1/47-132 --QLKDIPR...TGWV.RA.G..VE..NP...ESVAAHSWGMA.LL.A....LRMC....PEH-......--L...DLSK...VLSMC...LVHDVAEIVVGDLTPHD.....A.IKGQQ...KHELERAGMLKI.AP-......----..........--.--------........------------..........------------------------.----------------------- EBP64502.1/21-159 ----DQVKR...AGYI.LR.G..VP..EP...ESVAAHSHFVA.VL.T....LLVC....DEYP......ADF...DRDK...AITLA...LTHDLCEAQLMDIPMPVa...dA.HLKEA...KDVAEQAITEKL.FAG......FDEK..........--.--YAHYHQ........EFLDASTPEAQL..........IRGLDKVQMMLKILMYQQEGKGRLkEF--------------------- ECE85580.1/3-102 ---------...----.--.-..--..--...-----------.-L.V....LLME....RDL-......PAL...DLTR...LLKLC...VIHDLGEAISGDIPAIH.....Q.TPGSS...KAAEERADFLSL.IAP......LPDD..........LR.TDFLGLWD........EYEAAETVEAQV..........AKGLDKIETMAQHVS---------.----------------------- ECQ81757.1/1-106 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----VEIDAGDMFAFN.....HpNDHDE...QAEKEVAAAKRI.FGL......LPSP..........LD.NEMLELWL........EFEAAETADAEF..........AKSMDRVLPVFQNMKDNGGSWKRH.GIAREKIEKR-NAHLKSCAPALW 2001337769/2-96 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...---------------YD.....S.VKNHI...NTDEELMAAKRI.FGL......LPKE..........QA.EECIAIWN........EFEEGKTNEVKF..........AKSMDRFEPLLQNVSNDGGTWKEF.DVPYEKVYEK-KKAIKNGSAAIW EBH89721.1/1-98 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...--RMA...LLHDLAESIIGDITP-D.....H.ITKNE...KNAKENNAIKQI.LKN......LPDD..........IT.ESYFEIWN........DYQKKISKEAIL..........LHEIDKLEMAFQAKFYQKKGITKE.--DLKTFFDT------------- ECS21942.1/11-108 --GLKNLPR...AGWK.VKlN..MK..DS...ESVAEHSYMMS.VM.A....MVLS....DTKD......--L...NTEK...ILKMS...ILHDWAESKIGDFM-PD.....E.ITNEK...KTELEEYAMTEI.LDD......LPTK..........IK.NDYY----........------------..........------------------------.----------------------- ECD05997.1/29-156 --RLKTEIR...YAQK.RD.D..QT..DT...ESVAEHIYGMH.VL.A...hYFLP....LEES.....gEAM...DTQK...VFQLI...TWHDMDEIETGDVVSHW.....-.-KTEQ...HRIDAEQALPVV.LSK......MPSL..........LS.HYVAPLIE........EYEQQRSPEAQF..........VKAIDKAEPLFE------------.----------------------- ECE86587.1/29-159 --ALKREIR...YNLA.RA.E..ER..TT...ESVAEHVYGMH.VL.G....RYFHq..lESAA......EPL...SYDR...IQSLI...TWHDVDEVETGDIVSWR.....-.-KTDT...DRERERTASAVV.LDR......IPAL..........IR.SDVASLLE........EYEAQATREARF..........VKALDKIEPLFECCN---------.----------------------- ECH48179.1/13-88 ---LKDVLR...QGWV.NI.G..VE..AP...ESVAAHSWGMA.IL.A....LKLC....PPE-......--L...NIER...VLTLC...LVHDLPEVVVGDLTPHD.....D.RSSKA...KDERN-------.---......----..........--.--------........------------..........------------------------.----------------------- EBF32245.1/8-131 ---------...----.--.-..--..--...-----------.--.T....YFLP...lEDPG......RTW...DWQK...VYEMI...TWHDIDEIETGDTIGYL.....-.-KTDA...DRAAEAAAEQKI.IDQ......LPEH..........LK.AHITALLA........EYKARDTVEAKF..........VKAIDKIEPQIHLYHEEGKELVHRhGTYYEDHRRIKEPYV-------- EBU69113.1/1-98 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...VLSMC...LVHDIAEIVVGDLTPHD.....D.IRGEE...KHRLEREAMMKI.APQ......----..........--.--WVELFD........EYEQGESEEAQF..........VKTMDKLDMGLQAMNYQQQSLDLS.EFITSAQSRTHGT---------- EBU41325.1/31-173 --TLRKVLRmhrQTLL.TD.D..--..MS...DNIATHSYRVA.MI.G....WILA....KRAG......--A...DPYK...VVMMC...LLHDMGEGRSNDHNW--.....-.VHKRY...IKVFDEEIIKDQ.LDT......LPDP..........--.-ELGQLAH........EYEARESKEAII..........AKDADLLDQVLLLREYEWQGNKEA.VIWLRGKQGE------------- EBG71891.1/2-95 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-LKMA...VIHDLGEAVVGDIPAFL.....-.VKDAT...AKKKKQELEEGA.FKS......ISES..........LGnEELFELWK........EFEEGISYEAQY..........VRALDRLEMQIQHNQSDLSTWLDI.EK--------------------- 2000603530/16-84 AERLKDVLR...TAHT.RT.G..--..KQ...ESTAEHTWRLC.LF.I....LCFA....DQL-......PDL...NLLK...VLKMA...VLHDLGEAIHGDIPAID.....Q.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF39781.1/16-149 -GTLRRINR...-SHR.QN.LlvND..DT...DNIASHSFRVT.WI.G....WHLA....KLEG......--A...DPHK...VTMMC...LLHDLGEARSNDMNW--.....-.IHKRY...VTVHDDEITEEQ.LGT......LPFP..........--.-ELKELVQ........EYSARQSLEAKV..........AKDSDNLDQILLLKEYEWQGNQEA.----------------------- EBV71885.1/23-88 --NLKTKPR...RGWQ.KKiG..IK..KP...ESVADHAYAVA.TI.A....MILS....DSKK......--L...NSEK...ILKMA...LLHDLAESITGDLTP--.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- 2004031701/3-80 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.-----...---------RRL.YGL......LPED..........QG.AKLKAIWE........EFEAKNTPESRF..........AHTMDNLQPVILNAATDGKAWKEH.QVRLSQFMGR-QEDTPKGSETLW 2001327615/11-172 -SRLRFIKR...--WG.LM.R..NA..VE...EDVAQHSWEVA.VL.A....HALAvirrDVFG......GAI...DPNA...VATRA...LFHDATEAITGDLPTPVk..ysP.SMRHA...TAHLEHEVGQEM.LAL......LPRP..........VR.DGIAQVMD........-HDEWPADHAEL..........VKAADRLAAWLKCKAELRYGNREFeQAEQQIRAKMAEHRLA------- EBG38922.1/30-156 --------R...SHNK.QL.G..T-..TF...DNVASHSHHVA.VI.A....YCLC....RMED.....lTHE...QAME...ATTMA...VFHDLAEARTGDL---D.....F.VAKHY...AENDEEKAVEDQ.FSG......F--D..........FG.KDLKDLID........QYEERDTLVAKC..........AKDADSLDQIYQEWVLMWQGNK--.----------------------- EBB71224.1/22-156 -------ER...--AT.GH.P..DG..RP...ETDTTHTVMLG.LV.A....VHLA....PRYG......--L...YPGA...VALMA...LAHDLPEALCGDVPTLHt..ltP.EARAA...KDAAEEAALGEI.ART......----..........-S.DALGVLLH........AYEARVSPEARF..........VHCLDKLLPKLMAIQDEGRAARRW.GADLDQ----------------- 2004029449/11-170 -SRMRYINR...--WG.LM.N..NT..RC...ENLSEHSLDVA.VI.A....HCLV....LIHNkr..fgGNL...NAER...AALLA...LFHDATEIITGDMPTPVkyfnpE.IKNAY...-KEIEATAGNRL.VSM......LPDD..........FK.DDMDKIIK........MNGTGDDELKKY..........VKAADKFSALIKCIEEIKMGNSEFsKAKEATEKSIHN----------- EDA36239.1/10-158 -ARMKLIQR...--WP.LM.Y..NV..RT...ENVQEHSLQVA.MV.AhalvIISN....KKFG......TSL...DAHQ...ATSLA...IFHDASEILTGDLPTPV.....KyFNKEIeaeYKKIEAIAEQRM.LDM......VPDD..........FK.EDYRSLFI.......sDYADPIYK--AI..........VKSADTLCAYLKCLEENRAGNTEF.NTA-------------------- EBM43814.1/23-138 ---LQHTKR...--YS.MK.P..VL..HP...ESVATHSYFVA.LA.V....LLHR....DVWM......--F...DTST...AIKIA...LCHDLAEMEISDVNHYV.....K.KRHPE...VAQALKKAEDTI.IKS......FPES..........--.--IQPYCK........MYEH-ESPESLV..........VHYADALQCY--------------.----------------------- ECV28813.1/10-159 -ARMKLIQR...--WP.LM.Y..NV..RT...ENVQEHSLQVA.MV.AhalvIISN....KKFG......TAL...DAHQ...ATSLA...IFHDASEILTGDLPTPV.....KyFNKEIeaeYKKIEAIAEQRM.LDM......VPDE..........FK.EDYRSLFI.......sDYADPIYK--AI..........VKSADTLCAYLKCLEENRAGNTEF.NTAR------------------- EDA53413.1/17-162 --RMKLINR...--WP.LM.R..NV..NT...ENVAEHSHQVA.VV.A....HMLAlirrEVFA......GEV...QPER...VATLA...LFHDASEVLTGDLPTPVkyfnaQ.IAQ-E...YKKIERIAEQKL.LSM......LPEK..........LQ.PFYQSLLLs......dQYSA---DEKLL..........VKAADTLCAYVKTLEELSAGNHEF.V---------------------- ECL79367.1/8-153 -SRMKFFYR...--WG.LM.R..NT..QS...ENVQEHSLQVA.MI.A....HALAvignQEFG......EEN...DVGR...VVSVA...LYHDASEIITGDLPTPVky.frE.DIRDS...YKALEAHAERKI.TNL......LPAS..........LR.ESFAEVIE........S-ARIEPGVLRL..........VKAADSLSAYLKCIEERAAGNREF.----------------------- ECU88233.1/9-158 -ARMKLIQR...--WP.LM.Y..NV..RT...ENVQEHSLQVA.MV.AhalvIISN....KKFG......TTL...DAHQ...ATSLA...IFHDASEILTGDLPTPV.....KyFNKEIeaeYKKIEAIAEQRM.LDM......VPDE..........FK.EDYRSLFI........SDNADPIYKA-I..........VKSADTLCAYLKCLEENRAGNTEF.NTAR------------------- EDA69095.1/58-202 --RMKLINR...--WP.LM.R..NV..NT...ENVAEHSHQVA.VV.A....HMLA....LIRRei..faGEV...HPER...VATLA...LFHDASEVLTGDLPTPVkyfnaQ.IAQ-E...YKKIERIAEHKL.LSM......LPEK..........LQ.PFYQTLLL........S-EQYSADEKLL..........VKAADTLCAYVKTLEEISAGNHEF.----------------------- EBF99851.1/16-168 -SRLRWIKR...WGLM.RN.A..--..IE...ENVATHSWEVA.TL.A....HALAlirnRHFG......GQV...NADR...IAAAA...LYHDATEVITGDMPTPVky.hsK.VMREA...FGDVEHKAEGEL.LSL......LPEE..........LR.DDFAPYVR........ESR-LPAEDKEL..........IKAADRLSAWLKCQAEIRAGNAEF.EPAAKQI---------------- EBG46322.1/3-102 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...---YA...MIHDLVEVYAGDTFCFA.....DkNQLDQ...KPLKEAKAMQRL.IHE......YRDL..........--.PPLTQALQ........EYEKLANEEARF..........IRALDKLQGIIVNYLDGGRVWHEN.DISFDEMFTNK------------ ECL59140.1/10-83 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...----------GDF-MPD.....Q.IGYDK...KSELESYAMSEI.LES......LPQK..........IQ.DDYQNMWN........EFLLRETPEARL..........VHELDKLEMALQAKIYEKDVD---.----------------------- ECW26205.1/60-183 -------PR...AGWV.RI.G.aPG..PI...ETVAEHTDDMV.ML.A....GMLN....APG-......--Y...QLDR...VQRMA...KVHDLPEGASADITPKS.....D.ISKAD...KKRLEHIAATII.FES......D---..........-A.TGMLADWR........EFEFGSSPERTL..........THDLDQLQMLGKALEIEAN-----.----------------------- 2001267733/28-90 -NQLKLLFR...QGWL.RK.GisQE..RC...ESVAEHVFSMA.VL.G....WWIA....DALF......PEL...DRDR...MLRMV...LVHELGES---------.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EDC62658.1/1-92 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...----LAEIVVGDLTPHD.....D.IKGQE...KHDLERVGMLKI.APQ......----..........--.--WIDLFD........EYEQGTSEEARF..........VKTMDKLDMGLQAMNYQQQGLDLN.EFVTSARSKTDQTEFA------- ECE61431.1/4-66 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.---DK...KSELEKYAMIEI.LES......LPQQ..........LQ.SDYQKIWD........EFLVRDTPEARL..........VHELDKLEMALQAKIYEKEV----.----------------------- ECP58583.1/11-98 -SRLKLINR...--WP.LM.R..NV..RT...ENVSEHSLQVA.MV.A....HALA....AIKNrk..fgGQV...NAER...IALLA...MYHDASEVLTGDLPTPV.....KyFNSQI...AQ--EYKAIEK-.---......----..........--.--------........------------..........------------------------.----------------------- ECB28755.1/2-86 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...---MC...LFHDLPEARTGDQNYVN.....-.-KRYV...QADEEKALADQM.KGL......F---..........FG.EDIQALIR........EFNGCDTLEARL..........SKDADQLDLILELKEQLDLGNQNA.----------------------- EDJ62400.1/3-81 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.-----...--KLENQAMNEI.LDK......LPNN..........LA.EVYKKIWN........EFQLCQSEESIF..........VHEMDKLEMVFQAKTYLNKGFP--.RQKIQSFIDSANKEIKNK----- ECM79650.1/4-138 ---------...----.--.-..-T..QA...ENIQEHSLQVA.MI.A....HALA....VLKNtr..fgGSV...NPDR...AALLA...VFHDAEEVITGDLPTPIkyftpE.VADAI...G-GVADVARSRL.VSM......LPSD..........QR.SAYEPLF-........-FAREEDAEAWA.........cVKAADKLAAYFKCIEEHKAGNAEFgKA--------------------- 2004003203/1-64 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.-----...------------.---......----..........--.--MMNLWL........EFESGETAEAKF..........AHTMDNIQPAMLNDATDGKAWVEH.IVHLHSILNR-NKNTADGSKKLW 2004022490/4-146 ---------...----.--.-..-T..RA...ESLSEHTADTA.ML.A....HTLC....LIGKsctgtgAAL...RPEV...VATAA...LYHDAPEILTGDMPTPVky.knD.ALRTA...YKAVEHESARVM.ASL......QPAE..........LQ.AETQAWLT........-GSVLNDAERKI..........LKAADRLSAIIKCIEEDRGGNREF.EAARTQQMD-------------- EDB07243.1/1-78 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...------EVIVGDLTPAD.....-.-DRST...KAADERAAMQEL.A--......----..........--.PEWVALFD........EYEQQSTPEAVF..........VRSLDKLDMALQAKVYMERTDLD-.---LHQFIES------------- EBB53579.1/32-71 -DQLKAVKR...QITL.LC.D..NY..RQ...ENSAEHSWHVA.LM.G....NMLS....EYA-......---...----...-----...-----------------.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- 2004005245/10-78 -SRLKYIAR...--WG.LM.R..ST..IP...ENDAEHTLQTA.MI.A....HALA....LIRHdi..fhEPT...DPEH...CAMLA...LYHDASEVFTGDLP---.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- 2001363003/3-60 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.-----...------------.---......LKET..........NG.QEIYDLFY........EFEEKKTYEAQV..........ANALDKLEVQLQHNHADFSTWEKI.EYEMCYMM--------------- EBS13631.1/25-185 -------KR...--WA.LM.H..CF..QE...ENVSEHCHQVG.VI.A....HLLAiiknKYFD......GDI...NPDR...VATVA...LYHEVSETKLQDINSNTkyhspE.FTKAF...-KKLEELAEIEC.LES......LPEE..........LQ.PEMESLLV........QSK-VDDEYKKI..........VKAADIIQAYVKTKNELRFNNNEF.-IHVEENISKKLNQLKQEMPEV- EBE84336.1/19-62 --SLKHVLR...EGWV.RA.G..VE..SP...ESVAAHSWGMS.VL.A....MHLC....PEN-......--L...DRMR...-----...-----------------.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECQ61174.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF67931.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVYp...elSSA...DQVL...LYELA...LMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF86036.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVYp...elSSA...DQVL...LYELA...LMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECT67365.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECG63741.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF99275.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECH49698.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF52119.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECU29005.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECM78864.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF75926.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSEDqvvLYELA...LMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF29277.1/60-141 -------PR...AGWV.RI.G.aPG..PI...ETVAEHTDDMV.ML.A....GMLN....APG-......--Y...RLDM...VQRMA...KVHDLPEGASADITPKS.....G.ISKAD...KKRLEHIAATII.FE-......----..........--.--------........------------..........------------------------.----------------------- EBF54896.1/13-79 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF13434.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECV91022.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECW38121.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF81682.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECW46692.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECV96661.1/19-85 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF42087.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBG00104.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECW17844.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECW35895.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBF95209.1/17-83 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECT05329.1/25-109 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-------------PPHD.....G.VPPAE...KHRREDAAAAEL.LAD......A---..........--.PDLLRLFR........DYAERRTPAARF..........VRQLDKLDMALQAEIYAADGADTA.EFVESARRGITDPSL-------- EBG29123.1/16-158 --KLREIKR...YSMF.DV.Y..Q-..YR...SSVWDHQLRVY.LI.Vk.elTLLV....EKFL......PQC...NISK...ARMIA...LVHDDAEMITGDVQLGH.....KqNMSPE...ELKAVDDAEAKV.IEF......LTDNcffpetpetiNG.YSYRKLLL........NALHKDCIEAQL..........VSYADKLDAFCESL----------.----------------------- EBD46766.1/8-57 ---------...----.--.-..--..--...-----------.--.-....----....----......---...----...-----...-----------------.....-.-----...------------.---......----..........--.PKWLELFL........EYESQETPESKF..........VKYVDKLDMALMASLYEEEHGL--.--DLSEFISS------------- EBF19736.1/17-77 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGD-----.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECW30058.1/17-77 ------VTR...--WH.SV.N..CH..RY...PSVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGD-----.....-.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECR13355.1/5-61 ---------...----.--.-..--..RY...PSVAEHSCLVA.LY.A....REIA....SRVY......PSL...SAEDqvlLYELA...LMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECA92684.1/17-85 ------VTR...--WH.SV.N..CH..RY...PSVPEHLCLVA.LY.A....REIA....YRVY......PSLsaeDQVL...LYELA...LMHDLSEVVTGDMPSPI.....K.RH---...------------.---......----..........--.--------........------------..........------------------------.----------------------- ECV99153.1/3-56 ---------...----.--.-..--..--...-SVAEHSCLVA.LY.A....REIA....ARVY......PEL...SSED...QVLLYelaLMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EDB98002.1/60-163 ---------...----.--.-..--..NG...QTTGKHPYSVA.QH.S....MLVE....ELFN.....iEYP...NLDK...KWNLA..aLLHDAPEYVIGDLITPF.....KyALNNS...YRYVEDNLMKAI.YLRfglpaiLPKQ..........IE.TKIKKIDKa.....laWFEA--------..........------------------------.----------------------- 2001295510/48-115 ---------...----.--.-..--..NG...QTHGEHAFSVA.QH.S....LVVE....QVFRl....qNPE...CTAA...DCQMA...LLHDAAEYVIGDMISPFk...aV.VGGGY...KAVEQ-------.---......----..........--.--------........------------..........------------------------.----------------------- EBV61749.1/39-135 -----FVAR...WNGQ.TH.G..-D..FP...YSVAEHSLLVEqIY.S....KLYK....NPE-......---...--KK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENR-LSSAInLRFgl.ptkLPEN..........IK.KQI-----........------------..........------------------------.----------------------- EBX47944.1/59-121 ---------...----.--.-..--..FS...YSVAEHSLLVE.KI.F....FKLN....PKVS......---...--NK...WKLAA...LLHDAPEYVIGDMISPV.....KaAIGPT...YAQLEDKL----.---......----..........--.--------........------------..........------------------------.----------------------- ECU26793.1/49-112 ---------...----.--.-..--..FP...YSVAEHSLLVE.--.-....QIYS....NSLK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...tA.IGSDY...KSLENRLS----.---......----..........--.--------........------------..........------------------------.----------------------- ECV23895.1/50-135 ---------...----.--.-..-D..FP...YSVAEHSLLVEqIY.S....KLYK....NPE-......---...--KK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENR-LSSAInLRFgl.ptkLPEN..........IK.KQI-----........------------..........------------------------.----------------------- ECV96166.1/1-52 ---------...----.--.-..--..--...---AEHSCLVA.LY.A....REIA....ARVYp...elSSA...DQVL...LYELA...LMHDLSEVVTGDMPSPI.....K.-----...------------.---......----..........--.--------........------------..........------------------------.----------------------- EBJ47202.1/38-111 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- ECV79119.1/38-112 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENRL-----.---......----..........--.--------........------------..........------------------------.----------------------- ECB43686.1/63-136 ---------...----.QT.N..GT..EP...YSVAEHSLLVE.R-.-....LFTE....NSSE......---...KQSK...WRLAA...LLHDAPEYVIGDMISPF.....KaVIGDE...YRSVEQRLQEAI.HL-......----..........--.--------........------------..........------------------------.----------------------- EBC06120.1/37-109 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--T...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLEN-------.---......----..........--.--------........------------..........------------------------.----------------------- EBD96526.1/37-109 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--T...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLEN-------.---......----..........--.--------........------------..........------------------------.----------------------- EBU03607.1/49-105 ---------...----.--.-..--..FP...YSVAEHSLLVE.K-.-....-IYS....NSFK......--H...PEKK...WCMAA...LLHDAPEYVIGDMISPVk...sA.IGSHY...Q-----------.---......----..........--.--------........------------..........------------------------.----------------------- EDI71748.1/56-120 ---------...----.--.-..GE..FA...YSVAEHSLLVV.EL.S....KRLF....PKIE......---...--AK...WQLAA...LLHDAPEYVIGDMISPVk...aA.VGAGY...EALDERL-----.---......----..........--.--------........------------..........------------------------.----------------------- EDC49985.1/38-109 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLE--------.---......----..........--.--------........------------..........------------------------.----------------------- EDD12569.1/37-110 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PERK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGNDY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- EDB78255.1/37-110 -----FVAR...--WNgQT.N..GN..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- EBC90351.1/38-111 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WRLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- EBD84596.1/37-105 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVEqIY.A....KFFK....NPEK......---...---K...WRLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...Q-----------.---......----..........--.--------........------------..........------------------------.----------------------- EBH05856.1/37-110 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- ECH80805.1/45-117 ---------...----.QT.N..GT..EP...YSVAEHSLLVE.RL.-....-FTE....NSPE......---...KHSK...WRLAA...LLHDAPEYVIGDMISPF.....KaVIGDE...YRSVEQRLQEAI.H--......----..........--.--------........------------..........------------------------.----------------------- EBE06371.1/38-111 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WRLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENR------.---......----..........--.--------........------------..........------------------------.----------------------- ECS43232.1/38-112 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WRLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENRL-----.---......----..........--.--------........------------..........------------------------.----------------------- ECS43230.1/38-112 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WRLAA...LLHDAPEYVIGDMISPVk...sA.IGSDY...QSLENRL-----.---......----..........--.--------........------------..........------------------------.----------------------- ECY65287.1/6-77 ---------...----.--.-..GT..EP...YSVAEHSLLVE.RL.-....-FTE....NSPE......---...KHSK...WRLAA...LLHDAPEYVIGDMISPF.....KaVIGDE...YRSVEQRLQEAI.HLR......----..........--.--------........------------..........------------------------.----------------------- ECA13796.1/55-115 ---------...----.--.-..--..NG...FSVAEHSLLVE.TL.F....RNFY....PDTD......---...--PK...WRMAA...LLHDAAEYVIGDLISPVk...aG.IGEKY...SELEE-------.---......----..........--.--------........------------..........------------------------.----------------------- ECA97378.1/37-108 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PEKK...WCLAA...LLHDAPEYVIGDMISPVk...sA.IGSGY...QSLE--------.---......----..........--.--------........------------..........------------------------.----------------------- EBZ27555.1/37-100 -----FVAR...--WNgQT.N..GD..FP...YSVAEHSLLVE.--.-....QIYS....KSFK......--N...PERK...WCLAA...LLHDAPEYVIGDMISPVk...sA.I----...------------.---......----..........--.--------........------------..........------------------------.----------------------- #=GC PP_cons 5789*9999...9998.88.8..88..99...**********9.**.9....9998....8888......788...8999...99999...***************99.....6.88888...888889999999.999......9*99..........99.9999****........**9*********..........**************9999998888.88887777777777777788777 #=GC RF xxxxxxxxx...xxxx.xx.x..xx..xx...xxxxxxxxxxx.xx.x....xxxx....xxxx......xxx...xxxx...xxxxx...xxxxxxxxxxxxxxxxx.....x.xxxxx...xxxxxxxxxxxx.xxx......xxxx..........xx.xxxxxxxx........xxxxxxxxxxxx..........xxxxxxxxxxxxxxxxxxxxxxxx.xxxxxxxxxxxxxxxxxxxxxxx //