Summary: Clustered mitochondria
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The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport [1,2] although the exact function of the domain is unknown . In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane  suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast . Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre . It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure .
Zhu Q, Hulen D, Liu T, Clarke M;, Proc Natl Acad Sci U S A. 1997;94:7308-7313.: The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria. PUBMED:9207087 EPMC:9207087
Cox RT, Spradling AC;, Dis Model Mech. 2009;2:490-499.: Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. PUBMED:19638420 EPMC:19638420
Sugden C, Ross S, Bloomfield G, Ivens A, Skelton J, Mueller-Taubenberger A, Williams JG;, J Biol Chem. 2010;285:22927-22935.: Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development. PUBMED:20457612 EPMC:20457612
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025697
The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in highly conserved eukaryotic proteins required for correct mitochondrial dispersal [PUBMED:9207087, PUBMED:12952081]. The exact function of the domain is unknown [PUBMED:20457612].
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Curation and family details
|Author:||Fey P, Coggill P|
|Number in seed:||42|
|Number in full:||412|
|Average length of the domain:||207.90 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||16.22 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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