Summary: Phosphotransferase system, EIIC
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The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.
Internal database links
|Similarity to PfamA using HHSearch:||PTS_EIIC|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003352The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The general mechanism of the PTS is the following: a phosphoryl group from phosphoenolpyruvate (PEP) is transferred to enzyme-I (EI) of PTS which in turn transfers it to a phosphoryl carrier protein (HPr). Phospho-HPr then transfers the phosphoryl group to a sugar-specific permease which consists of at least three structurally distinct domains (IIA, IIB, and IIC) [PUBMED:1537788] which can either be fused together in a single polypeptide chain or exist as two or three interactive chains, formerly called enzymes II (EII) and III (EIII). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Molecular function||sugar:hydrogen symporter activity (GO:0005351)|
|protein-N(PI)-phosphohistidine-sugar phosphotransferase activity (GO:0008982)|
|Biological process||phosphoenolpyruvate-dependent sugar phosphotransferase system (GO:0009401)|
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Curation and family details
|Number in seed:||67|
|Number in full:||1977|
|Average length of the domain:||317.10 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||92.29 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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