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319  structures 5501  species 0  interactions 114885  sequences 8442  architectures

Family: TPR_12 (PF13424)

Summary: Tetratricopeptide repeat

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Tetratricopeptide repeat Provide feedback

No Pfam abstract.

Internal database links

This tab holds annotation information from the InterPro database.

No InterPro data for this Pfam family.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(120)
Full
(114885)
Representative proteomes UniProt
(322488)
RP15
(25041)
RP35
(56471)
RP55
(104345)
RP75
(153160)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(120)
Full
(114885)
Representative proteomes UniProt
(322488)
RP15
(25041)
RP35
(56471)
RP55
(104345)
RP75
(153160)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(120)
Full
(114885)
Representative proteomes UniProt
(322488)
RP15
(25041)
RP35
(56471)
RP55
(104345)
RP75
(153160)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Jackhmmer:B0SDL4
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Coggill P
Number in seed: 120
Number in full: 114885
Average length of the domain: 72.70 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 23.19 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 30.1 30.1
Trusted cut-off 30.1 30.1
Noise cut-off 30.0 30.0
Model length: 77
Family (HMM) version: 8
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TPR_12 domain has been found. There are 319 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096MK92 View 3D Structure Click here
A0A0G2JXJ6 View 3D Structure Click here
A0A0N7KC65 View 3D Structure Click here
A0A0P0VQW4 View 3D Structure Click here
A0A0P0VV58 View 3D Structure Click here
A0A0P0VV58 View 3D Structure Click here
A0A0R0FJ27 View 3D Structure Click here
A0A0R0FJ27 View 3D Structure Click here
A0A0R0HNZ6 View 3D Structure Click here
A0A0R0K9R9 View 3D Structure Click here
A0A0R0K9R9 View 3D Structure Click here
A0A0R0K9R9 View 3D Structure Click here
A0A0U1RRV5 View 3D Structure Click here
A0A0U1RRV5 View 3D Structure Click here
A0A1D6DW96 View 3D Structure Click here
A0A1D6DW96 View 3D Structure Click here
A0A1D6DW96 View 3D Structure Click here
A0A1D6GNR8 View 3D Structure Click here
A0A1D6GNR8 View 3D Structure Click here
A0A1D6HBT0 View 3D Structure Click here
A0A1D6HBT0 View 3D Structure Click here
A0A1D6HHP2 View 3D Structure Click here
A0A1D6HIA8 View 3D Structure Click here
A0A1D6HIA8 View 3D Structure Click here
A0A1D6HN31 View 3D Structure Click here
A0A1D6HN31 View 3D Structure Click here
A0A1D6HXX3 View 3D Structure Click here
A0A1D6HXX3 View 3D Structure Click here
A0A1D6JFQ5 View 3D Structure Click here
A0A1D6JFQ5 View 3D Structure Click here
A0A1D6JFQ5 View 3D Structure Click here
A0A1D6Q8M9 View 3D Structure Click here
A0A1D6QD57 View 3D Structure Click here
A0A1D6QUW6 View 3D Structure Click here
A0A1D6QUW6 View 3D Structure Click here
A0A1D6QUW6 View 3D Structure Click here
A0A1D6QUW6 View 3D Structure Click here
A0A1D8PMB5 View 3D Structure Click here
A0A2R8PZ91 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8PZK5 View 3D Structure Click here
A0A2R8Q6P4 View 3D Structure Click here
A0A2R8Q6P4 View 3D Structure Click here
A0A2R8Q6P4 View 3D Structure Click here
A0A2R8Q6P4 View 3D Structure Click here
A0A5K1K972 View 3D Structure Click here
A0JMD0 View 3D Structure Click here
A0JMD0 View 3D Structure Click here
A1ZAB5 View 3D Structure Click here
A2A3L6 View 3D Structure Click here
A3KDM3 View 3D Structure Click here
A4HTP4 View 3D Structure Click here
A4HVF4 View 3D Structure Click here
A4I5A0 View 3D Structure Click here
A4I968 View 3D Structure Click here
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A4IAW6 View 3D Structure Click here
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A4QP73 View 3D Structure Click here
A5HK05 View 3D Structure Click here
A6H6E9 View 3D Structure Click here
A6NLP5 View 3D Structure Click here
A8E7I5 View 3D Structure Click here
B0S6W0 View 3D Structure Click here
B0S729 View 3D Structure Click here
B2GV74 View 3D Structure Click here
B2GV74 View 3D Structure Click here
B2GV74 View 3D Structure Click here
B2GV74 View 3D Structure Click here
B3DNN5 View 3D Structure Click here
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B4FAP9 View 3D Structure Click here
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B4G0Z0 View 3D Structure Click here
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B4G0Z0 View 3D Structure Click here
C0P732 View 3D Structure Click here
C6TK03 View 3D Structure Click here
C7J143 View 3D Structure Click here
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D3ZCE5 View 3D Structure Click here
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E9QCZ1 View 3D Structure Click here
E9QI21 View 3D Structure Click here
F1LUG6 View 3D Structure Click here
F1M369 View 3D Structure Click here
F1QHY2 View 3D Structure Click here
F1QMV4 View 3D Structure Click here
F1QS14 View 3D Structure Click here
F1QS14 View 3D Structure Click here
F1QS14 View 3D Structure Click here
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F1QVN7 View 3D Structure Click here
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F1R4Z4 View 3D Structure Click here
F1R646 View 3D Structure Click here
F1R646 View 3D Structure Click here
F1R646 View 3D Structure Click here
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F1RD24 View 3D Structure Click here
F4HS99 View 3D Structure Click here
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F4JKH6 View 3D Structure Click here
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I1K675 View 3D Structure Click here
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I1KC83 View 3D Structure Click here
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I1KHE4 View 3D Structure Click here
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K7KL29 View 3D Structure Click here
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K7KR51 View 3D Structure Click here
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K7KVS9 View 3D Structure Click here
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O14879 View 3D Structure Click here
O15294 View 3D Structure Click here
O15818 View 3D Structure Click here
O16259 View 3D Structure Click here
O59742 View 3D Structure Click here
O75153 View 3D Structure Click here
O81629 View 3D Structure Click here
O81629 View 3D Structure Click here
O88447 View 3D Structure Click here
O88448 View 3D Structure Click here
P09914 View 3D Structure Click here
P0CI65 View 3D Structure Click here
P0CI65 View 3D Structure Click here
P0CI65 View 3D Structure Click here
P0CI65 View 3D Structure Click here
P0CI65 View 3D Structure Click here
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P37285 View 3D Structure Click here
P46822 View 3D Structure Click here
P46824 View 3D Structure Click here
P46824 View 3D Structure Click here
P46824 View 3D Structure Click here
P46824 View 3D Structure Click here
Q07866 View 3D Structure Click here
Q08CF1 View 3D Structure Click here
Q08CF1 View 3D Structure Click here
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Q0DV51 View 3D Structure Click here
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Q13042 View 3D Structure Click here
Q13325 View 3D Structure Click here
Q19955 View 3D Structure Click here
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Q337M8 View 3D Structure Click here
Q3UV71 View 3D Structure Click here
Q4D280 View 3D Structure Click here
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Q4DBK2 View 3D Structure Click here
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Q4DI61 View 3D Structure Click here
Q4DK03 View 3D Structure Click here
Q4DTV6 View 3D Structure Click here
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Q4DZ25 View 3D Structure Click here
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Q4DZ25 View 3D Structure Click here
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Q4E2W9 View 3D Structure Click here
Q4V884 View 3D Structure Click here
Q54D26 View 3D Structure Click here
Q54D26 View 3D Structure Click here
Q54D26 View 3D Structure Click here
Q54DA8 View 3D Structure Click here
Q54H74 View 3D Structure Click here
Q54KD0 View 3D Structure Click here
Q54KD0 View 3D Structure Click here
Q54LV4 View 3D Structure Click here
Q54TM1 View 3D Structure Click here
Q54ZA9 View 3D Structure Click here
Q54ZA9 View 3D Structure Click here
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Q56A06 View 3D Structure Click here
Q59MA9 View 3D Structure Click here
Q5PQM2 View 3D Structure Click here
Q5PQM2 View 3D Structure Click here
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Q5RKM3 View 3D Structure Click here
Q5SW19 View 3D Structure Click here
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Q5T764 View 3D Structure Click here
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Q66H45 View 3D Structure Click here
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Q68G30 View 3D Structure Click here
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Q68G30 View 3D Structure Click here
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Q6AYP3 View 3D Structure Click here
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Q6IR34 View 3D Structure Click here
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Q6K715 View 3D Structure Click here
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Q6NY32 View 3D Structure Click here
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Q6P597 View 3D Structure Click here
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Q6YY12 View 3D Structure Click here
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Q6Z901 View 3D Structure Click here
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Q6ZGV8 View 3D Structure Click here
Q6ZGV8 View 3D Structure Click here
Q7TNH6 View 3D Structure Click here
Q7TNH6 View 3D Structure Click here
Q7TNH6 View 3D Structure Click here
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Q7TNH6 View 3D Structure Click here
Q7TNH6 View 3D Structure Click here
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Q7XQE6 View 3D Structure Click here
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Q7Z494 View 3D Structure Click here
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Q80VM3 View 3D Structure Click here
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Q86TV6 View 3D Structure Click here
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Q9VF81 View 3D Structure Click here
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