Summary: Seven times multi-haem cytochrome CxxCH
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Seven times multi-haem cytochrome CxxCH Provide feedback
This domain carries up to seven CxxCH repeated sequence motifs, characteristic of multi-haem cytochromes.
Internal database links
|SCOOP:||Cytochrom_c3_2 Cytochrom_CIII Cytochrom_NNT PSCyt1 DHC Paired_CXXCH_1|
|Similarity to PfamA using HHSearch:||Cytochrom_C552 Cytochrom_NNT Cytochrome_C554 Cytochrom_c3_2|
External database links
This tab holds annotation information from the InterPro database.
No InterPro data for this Pfam family.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
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This family includes cytochromes that contain multiple CxxCH motifs.
The clan contains the following 11 members:CytoC_RC Cytochrom_c3_2 Cytochrom_C552 Cytochrom_CIII Cytochrom_NNT Cytochrome_C554 Cytochrome_C7 GSu_C4xC__C2xCH Multi-haem_cyto NapB Paired_CXXCH_1
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||11|
|Number in full:||1428|
|Average length of the domain:||181.40 aa|
|Average identity of full alignment:||54 %|
|Average coverage of the sequence by the domain:||67.74 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Multi-haem_cyto domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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