Summary: Amino acid permease
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Amino acid permease Edit Wikipedia article
|Amino acid permease|
Amino acid permeases are membrane permeases involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related. These proteins contain 12 transmembrane segments.
Human proteins containing this domain
- Weber E, Jund R, Chevallier MR (1988). "Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae". J. Mol. Evol. 27 (4): 341â€“350. doi:10.1007/BF02101197. PMID 3146645.
- Vandenbol M, Grenson M, Jauniaux JC (1989). "Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases". Gene. 83 (1): 153â€“159. doi:10.1016/0378-1119(89)90413-7. PMID 2687114.
- Reizer J, Reizer A, Finley K, Kakuda D, Saier Jr MH, MacLeod CL (1993). "Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria". Protein Sci. 2 (1): 20â€“30. doi:10.1002/pro.5560020103. PMC 2142299. PMID 8382989.
|This membrane proteinâ€“related article is a stub. You can help Wikipedia by expanding it.|
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Internal database links
|SCOOP:||AA_permease AA_permease_C Aa_trans Bax1-I Branch_AA_trans Claudin_2 DUF3493 K_trans Na_Ala_symp Nramp PMP22_Claudin Spore_permease SSF Tetraspanin Trp_Tyr_perm|
|Similarity to PfamA using HHSearch:||AA_permease Aa_trans Trp_Tyr_perm Spore_permease|
This tab holds annotation information from the InterPro database.
InterPro entry IPR002293Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [PUBMED:3146645, PUBMED:2687114, PUBMED:8382989]. These proteins include several yeast specific and general amino acid permeases; Emericella nidulans (Aspergillus nidulans) proline transport protein (gene prnB); Trichoderma harzianum amino acid permease INDA1; Salmonella typhimurium L-asparagine permease (gene ansP); and several Escherichia coli and other bacterial permeases and transport proteins. These proteins seem to contain up to 12 transmembrane segments. This entry consists of members of the amino acid-polyamine-organocation (APC) superfamily [PUBMED:10931886].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|Molecular function||transmembrane transporter activity (GO:0022857)|
|Biological process||transmembrane transport (GO:0055085)|
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.
The clan contains the following 20 members:AA_permease AA_permease_2 AA_permease_C Aa_trans BCCT BenE Branch_AA_trans CstA HCO3_cotransp K_trans MFS_MOT1 Na_Ala_symp Nramp SNF Spore_permease SSF Sulfate_transp Transp_cyt_pur Trp_Tyr_perm Xan_ur_permease
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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