Summary: NFkB-p65-degrading zinc protease
NFkB-p65-degrading zinc protease Provide feedback
This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65 thereby down-regulating the NF-kappaB signalling pathway . NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.
Yen H, Ooka T, Iguchi A, Hayashi T, Sugimoto N, Tobe T;, PLoS Pathog. 2010;6:e1001231.: NleC, a Type III Secretion Protease, Compromises NF-kappaB Activation by Targeting p65/RelA. PUBMED:21187904 EPMC:21187904
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This tab holds annotation information from the InterPro database.
InterPro entry IPR025208
This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65, thereby down-regulating the NF-kappaB signalling pathway [PUBMED:21187904]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.
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Curation and family details
|Author:||Rawlings N, Coggill P|
|Number in seed:||8|
|Number in full:||95|
|Average length of the domain:||246.90 aa|
|Average identity of full alignment:||84 %|
|Average coverage of the sequence by the domain:||71.65 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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