Summary: Sec63/Sec62 complex-interacting family
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Sec63/Sec62 complex-interacting family Provide feedback
This is a family of closely related Hph proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER. Cells with mutant Hph1 and Hph2 proteins revealed phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterized. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium .
Pina FJ, O'Donnell AF, Pagant S, Piao HL, Miller JP, Fields S, Miller EA, Cyert MS;, Eukaryot Cell. 2011;10:63-71.: Hph1 and hph2 are novel components of the sec63/sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. PUBMED:21097665 EPMC:21097665
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025752
This is a family of closely related high pH (HPH) proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions [PUBMED:15189990]. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER [PUBMED:21097665]. Cells with mutant HPH1 and HPH2 proteins reveal phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterised. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium.
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|Cellular component||endoplasmic reticulum (GO:0005783)|
|Biological process||response to stress (GO:0006950)|
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Curation and family details
|Author:||Wood V, Coggill P|
|Number in seed:||7|
|Number in full:||38|
|Average length of the domain:||171.50 aa|
|Average identity of full alignment:||38 %|
|Average coverage of the sequence by the domain:||32.47 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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