Summary: N-terminal region of glycosyl transferase group 7
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N-terminal region of glycosyl transferase group 7 Provide feedback
This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases. EC:18.104.22.168, N-acetyllactosamine synthase; EC:22.214.171.124, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:126.96.36.199 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:188.8.131.52 is the catalysed reaction.
Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I; , Proc Natl Acad Sci U S A 1998;95:472-477.: Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. PUBMED:9435216 EPMC:9435216
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H; , J Biol Chem 1998;273:29331-29340.: Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. PUBMED:9792633 EPMC:9792633
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This tab holds annotation information from the InterPro database.
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- the number of sequences which exhibit this architecture
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This example describes an architecture with one
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This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold .
The clan contains the following 44 members:Anp1 Caps_synth Cellulose_synt CgtA CHGN Chitin_synth_1 Chitin_synth_2 CofC CTP_transf_3 DUF2064 DUF273 DUF604 Fringe Galactosyl_T GlcNAc Gly_transf_sug Glyco_tranf_2_2 Glyco_tranf_2_3 Glyco_tranf_2_4 Glyco_tranf_2_5 Glyco_trans_2_3 Glyco_transf_21 Glyco_transf_25 Glyco_transf_34 Glyco_transf_43 Glyco_transf_49 Glyco_transf_6 Glyco_transf_64 Glyco_transf_7C Glyco_transf_7N Glyco_transf_8 Glyco_transf_92 Glycos_transf_2 GNT-I IspD Mannosyl_trans3 MGAT2 NTP_transf_3 NTP_transferase Nucleotid_trans Pox_P35 Rhamno_transf TcdA_TcdB UDPGP
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||4|
|Number in full:||775|
|Average length of the domain:||120.50 aa|
|Average identity of full alignment:||40 %|
|Average coverage of the sequence by the domain:||36.04 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_transf_7N domain has been found. There are 59 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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