Summary: ABC transporter transmembrane region
This is the Wikipedia entry entitled "Transmembrane domain of ABC transporters". More...
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Transmembrane domain of ABC transporters Edit Wikipedia article
|ABC transporter transmembrane region|
|OPM superfamily||Lipid/drug exporters 1.1.10.03. Lipid/drug exporters|
ABC transporter transmembrane domain is main transmembrane structural unit of ATP-binding cassette transporter which consist of six transmembrane domaines. Many members of the ABC transporter family (Pfam PF00005) have two such regions.
- Sulphate ABC transporter permease protein 2 IPR005667
- Phosphate transport system permease protein 2 IPR005672
- Phosphonate uptake transporter IPR005769
- Nitrate transport permease IPR005889
- NifC-like ABC-type porter IPR006469
- Phosphate ABC transporter, permease protein PstC IPR011864
- Molybdate ABC transporter, permease protein IPR011867
- Nickel ABC transporter, permease subunit NikB IPR014156
- Nickel ABC transporter, permease subunit NikC IPR014157
- Ectoine/hydroxyectoine ABC transporter, permease protein EhuD IPR014341
- Ectoine/hydroxyectoine ABC transporter, permease protein EhuC IPR014342
Human proteins containing this domain
- Kerr ID (2002). "Structure and association of ATP-binding cassette transporter nucleotide-binding domains". Biochim. Biophys. Acta 1561 (1): 47–64. PMID 11988180.
- Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). "Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter". Structure 9 (7): 571–86. doi:10.1016/S0969-2126(01)00617-7. PMID 11470432.
- Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). "The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter". J. Biol. Chem. 276 (34): 32313–21. doi:10.1074/jbc.M100758200. PMID 11402022.
- Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). "Crystal structure of the ATP-binding subunit of an ABC transporter". Nature 396 (6712): 703–707. doi:10.1038/25393. PMID 9872322.
- Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). "Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis". EMBO J. 19 (22): 5951–61. doi:10.1093/emboj/19.22.5951. PMC 305842. PMID 11080142.
- Wiley DC, Gaudet R (2001). "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): 4964–72. doi:10.1093/emboj/20.17.4964. PMC 125601. PMID 11532960.
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ABC transporter transmembrane region Provide feedback
This family represents a unit of six transmembrane helices.
External database links
This tab holds annotation information from the InterPro database.
No InterPro data for this Pfam family.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This clan includes families that are the membrane components of ABC transporter complexes. In general these regions are composed of six transmembrane helices .
The clan contains the following 4 members:ABC_membrane ABC_membrane_2 ABC_membrane_3 SbmA_BacA
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Number in seed:||20|
|Number in full:||130|
|Average length of the domain:||207.20 aa|
|Average identity of full alignment:||47 %|
|Average coverage of the sequence by the domain:||78.77 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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