Summary: GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
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GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p Provide feedback
The PC-Esterase family  is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/coldacclimatization proteins typified by Arabidopsis thaliana ESKIMO1  animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily . The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins . The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity . The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes . The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by the PC-Esterase domain .
Lefebvre V, Fortabat MN, Ducamp A, North HM, Maia-Grondard A, Trouverie J, Boursiac Y, Mouille G, Durand-Tardif M;, PLoS One. 2011;6:e16645.: ESKIMO1 disruption in Arabidopsis alters vascular tissue and impairs water transport. PUBMED:21408051 EPMC:21408051
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Curation and family details
|Number in seed:||109|
|Number in full:||1574|
|Average length of the domain:||250.40 aa|
|Average identity of full alignment:||20 %|
|Average coverage of the sequence by the domain:||56.82 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
|Download:||download the raw HMM for this family|
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