Summary: Growth-arrest specific micro-tubule binding
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Growth-arrest specific micro-tubule binding Provide feedback
This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages [1]. Gas8 is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells.
Literature references
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Yeh SD, Chen YJ, Chang AC, Ray R, She BR, Lee WS, Chiang HS, Cohen SN, Lin-Chao S;, J Biol Chem. 2002;277:6311-6317.: Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus. PUBMED:11751847 EPMC:11751847
Internal database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025593
This is the highly conserved central region of Gas8 proteins. Growth arrest-specific protein 8 (Gas8) is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages [PUBMED:11751847].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | motile cilium (GO:0031514) |
Biological process | cell motility (GO:0048870) |
Domain organisation
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Alignments
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Seed (50) |
Full (579) |
Representative proteomes | UniProt (1199) |
NCBI (1624) |
Meta (5) |
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RP15 (147) |
RP35 (247) |
RP55 (435) |
RP75 (585) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (50) |
Full (579) |
Representative proteomes | UniProt (1199) |
NCBI (1624) |
Meta (5) |
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RP15 (147) |
RP35 (247) |
RP55 (435) |
RP75 (585) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
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Trees
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Curation and family details
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Curation
Seed source: | Jackhmmer:O95995 |
Previous IDs: | none |
Type: | Coiled-coil |
Sequence Ontology: | SO:0001080 |
Author: |
Coggill P |
Number in seed: | 50 |
Number in full: | 579 |
Average length of the domain: | 178.70 aa |
Average identity of full alignment: | 39 % |
Average coverage of the sequence by the domain: | 39.61 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 200 | ||||||||||||
Family (HMM) version: | 7 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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