Summary: p21-C-terminal region-binding protein
p21-C-terminal region-binding protein Provide feedback
This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.
Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H;, J Biol Chem. 2000;275:31145-31154.: TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase. PUBMED:10878006 EPMC:10878006
Lu H, Yue J, Meng X, Nickoloff JA, Shen Z;, Nucleic Acids Res. 2007;35:7160-7170.: BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. PUBMED:17947333 EPMC:17947333
This tab holds annotation information from the InterPro database.
InterPro entry IPR025602
This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and Bcp1. In fungi, Bcp1 is involved in nuclear export, actin cytoskeleton organisation and vesicular transport [PUBMED:12912920]. Its homologue in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2 [PUBMED:14726710, PUBMED:10878006, PUBMED:15713648, PUBMED:17947333].
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the UniProtKB sequence database using the family HMM
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
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Curation and family details
|Number in seed:||191|
|Number in full:||859|
|Average length of the domain:||195.60 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||65.26 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||5|
|Download:||download the raw HMM for this family|
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