Summary: C-terminal duplication domain of Friend of PRMT1
C-terminal duplication domain of Friend of PRMT1 Provide feedback
Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation .
van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S;, Mol Cell Biol. 2010;30:260-272.: Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases. PUBMED:19858291 EPMC:19858291
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025715
This LDXXLDAYM region (where X is any amino acid) is duplicated in the C terminus of Friend of Prmt1 (Fop), which are chromatin-associated proteins that co-localise with facultative heterochromatin and are critical for oestrogen-dependent gene activation [PUBMED:19858291]. The region also occurs in other proteins, including THO complex subunit 4 (SWISSPROT) and RNA and export factor-binding protein 2 (SWISSPROT).
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Curation and family details
|Number in seed:||26|
|Number in full:||756|
|Average length of the domain:||71.60 aa|
|Average identity of full alignment:||26 %|
|Average coverage of the sequence by the domain:||28.78 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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