Summary: Potential Monad-binding region of RPAP3
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Potential Monad-binding region of RPAP3 Provide feedback
This domain is found at the C-terminus of RNA-polymerase II-associated proteins. These proteins bind to Monad and are involved in regulating apoptosis. They contain TPR-repeats towards the N_terminus.
Itsuki Y, Saeki M, Nakahara H, Egusa H, Irie Y, Terao Y, Kawabata S, Yatani H, Kamisaki Y;, FEBS Lett. 2008;582:2365-2370.: Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. PUBMED:18538670 EPMC:18538670
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025986
This domain is found at the C terminus of the RNA-polymerase II-associated protein 3 (RPAP3). RPAP3 binds to Monad and is involved in regulating apoptosis [PUBMED:18538670]. This domain represents the potential Monad-binding region of RPAP3. RPAP3 contains TPR-repeats towards the N terminus. This domain is also found in other proteins with TPR-repeats at the N terminus, like sperm-associated antigen 1 [PUBMED:11517287], and in proteins without TPR-repeats.
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Curation and family details
|Number in seed:||162|
|Number in full:||557|
|Average length of the domain:||91.60 aa|
|Average identity of full alignment:||23 %|
|Average coverage of the sequence by the domain:||18.10 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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