Summary: Phostensin PP1-binding and SH3-binding region
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Phostensin PP1-binding and SH3-binding region Provide feedback
Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton . Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends .
Kao SC, Chen CY, Wang SL, Yang JJ, Hung WC, Chen YC, Lai NS, Liu HT, Huang HL, Chen HC, Lin TH, Huang HB;, Biochem Biophys Res Commun. 2007;356:594-598.: Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit. PUBMED:17374523 EPMC:17374523
Lai NS, Wang TF, Wang SL, Chen CY, Yen JY, Huang HL, Li C, Huang KY, Liu SQ, Lin TH, Huang HB;, Biochem Biophys Res Commun. 2009;387:676-681.: Phostensin caps to the pointed end of actin filaments and modulates actin dynamics. PUBMED:19622346 EPMC:19622346
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025907
Phostensin has been identified as a PP1 regulatory protein, binding PP1 at the KISF motif found in this domain. This domain also appears to carry an incomplete SH3-binding domain PxRxP further upstream. It is likely that phostensin targets PP1 to the F-actin cytoskeleton [PUBMED:17374523]. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [PUBMED:19622346].
This domain is also found in the taperin, which is a PP1 binding protein that is ancestrally related to phostensin. Taperin has a role in sound perception [PUBMED:20170899].
|Molecular function||phosphatase binding (GO:0019902)|
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Curation and family details
|Number in seed:||5|
|Number in full:||99|
|Average length of the domain:||122.60 aa|
|Average identity of full alignment:||49 %|
|Average coverage of the sequence by the domain:||22.28 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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