Summary: Nuclear pore complex assembly
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Nuclear pore complex assembly Provide feedback
ELYS (embryonic large molecule derived from yolk sac) is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to human . It is important for the assembly of the nuclear pore complex .
Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W;, EMBO Rep. 2007;8:165-172.: MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. PUBMED:17235358 EPMC:17235358
Liu HL, De Souza CP, Osmani AH, Osmani SA;, Mol Biol Cell. 2009;20:616-630.: The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex. PUBMED:19019988 EPMC:19019988
This tab holds annotation information from the InterPro database.
InterPro entry IPR025151
This domain is found in ELYS (embryonic large molecule derived from yolk sac), which is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to humans [PUBMED:17235358]. ELYS is important for the assembly of the nuclear pore complex [PUBMED:19019988]. The domain is also found in other proteins, such as E3 ubiquitin-protein ligase HOS1.
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Curation and family details
|Author:||Wood V, Coggill P|
|Number in seed:||115|
|Number in full:||306|
|Average length of the domain:||220.00 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||21.29 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||3|
|Download:||download the raw HMM for this family|
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