Summary: WPP domain
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WPP domain Edit Wikipedia article
The domain is known to direct RanGAP to the nuclear envelope. Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1), WPP1 and WPP2.
The WPP stands for a tryptophan-proline-proline motif that is highly conserved in the domain. Either deletion of the WPP domain or mutation of both the namesake tryptophan and first proline residues into alanine in the Arabidopsis thaliana protein RanGAP1 leads to mis-targeting in the majority of cells.
- Meier I (December 2000). "A novel link between ran signal transduction and nuclear envelope proteins in plants". Plant Physiology 124 (4): 1507â€“10. PMC 1539304. PMID 11115866.
- Rose A, Meier I (December 2001). "A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim". Proceedings of the National Academy of Sciences of the United States of America 98 (26): 15377â€“82. doi:10.1073/pnas.261459698. PMC 65037. PMID 11752475.
- Patel S, Rose A, Meulia T, Dixit R, Cyr RJ, Meier I (December 2004). "Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division". The Plant Cell 16 (12): 3260â€“73. doi:10.1105/tpc.104.026740. PMC 535872. PMID 15548735.
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR025265The WPP domain is thought to be exclusively found in plants. The WPP stands for a tryptophan-proline-proline motif that is highly conserved in the domain [PUBMED:11115866]. The WPP domain is known to direct RanGAP (Ran GTPase-activating protein) to the nuclear envelope [PUBMED:11752475]. RanGAP is an accessory protein for the small signaling GTPase Ran, which is involved in nucleocytoplasmic transport. Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1) [PUBMED:11115866], WPP1 [PUBMED:15548735] and WPP2 [PUBMED:15548735].
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We make a range of alignments for each Pfam-A family:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Woodcraft BJ|
|Number in seed:||29|
|Number in full:||319|
|Average length of the domain:||95.30 aa|
|Average identity of full alignment:||55 %|
|Average coverage of the sequence by the domain:||21.28 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||2|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the WPP domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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