Summary: PgaD-like protein
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PgaD-like protein Provide feedback
This family includes the PgaD protein from E. coli P69432. The homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (beta-1,6-GlcNAc; PGA) serves as an adhesin for the maintenance of biofilm structural stability in eubacteria. The pgaABCD operon is required for its synthesis and export. It has been shown that PgaD is essential for this process .
Wang X, Preston JF 3rd, Romeo T;, J Bacteriol. 2004;186:2724-2734.: The pgaABCD locus of Escherichia coli promotes the synthesis of a polysaccharide adhesin required for biofilm formation. PUBMED:15090514 EPMC:15090514
Itoh Y, Rice JD, Goller C, Pannuri A, Taylor J, Meisner J, Beveridge TJ, Preston JF 3rd, Romeo T;, J Bacteriol. 2008;190:3670-3680.: Roles of pgaABCD genes in synthesis, modification, and export of the Escherichia coli biofilm adhesin poly-beta-1,6-N-acetyl-D-glucosamine. PUBMED:18359807 EPMC:18359807
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR023829
This entry represents the poly-beta-1,6-N-acetyl-D-glucosamine (PGA) biosynthesis protein PgaD. This cytoplasmic membrane protein appears to be an auxiliary subunit to the PGA synthase PgaC () [PUBMED:15090514, PUBMED:18359807, PUBMED:19460094]. PgaD is esential for the process of PGA synthesis and export. PGA serves as an adhesin for the maintenance of biofilm structural stability in bacteria.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Biological process||biofilm formation (GO:0042710)|
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Curation and family details
|Number in seed:||34|
|Number in full:||382|
|Average length of the domain:||123.60 aa|
|Average identity of full alignment:||45 %|
|Average coverage of the sequence by the domain:||83.02 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||1|
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